Uterine Neoplasms

Greer, BE; Wj, Koh; Abu‐Rustum, Nadeem R.; Ma, Bookman; Re, Bristow; Sm, Campos; Cho, Kathleen R.; Ma, Crispens; Pj, Eifel; Wk, Huh; Jaggernauth, Wainwright; Ds, Kapp; Jj, Kavanagh; Jr, Lurain; Morgan, Mark A.; Rj, Morgan; Cb, Powell; Sw, Remmenga; Rk, Reynolds; A, Alvarez Secord; Small, William; Teng, Nelson N.H.

doi:10.6004/jnccn.2009.0035

Cited by 67 publications

(28 citation statements)

References 120 publications

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“…Although cervical squamous cell carcinomas show very different biological behaviors compared to squamous cell carcinomas of the skin, we found interesting similarities in changes of expression of the miRNA machinery (11). Analogous to our observations in premalignant skin lesions (actinic keratoses), Muralidhar et al also did not observe an increase of Drosha expression in premalignant cervical SCC intraepithelial lesions (12).…”

Section: Drosha and Dicer Expression Levels In Epithelial Skinsupporting

confidence: 78%

Expression Levels of the microRNA Processing Enzymes Drosha and Dicer in Epithelial Skin Cancer

Sand

Gambichler

Skrygan

et al. 2010

Cancer Investigation

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Section: Drosha and Dicer Expression Levels In Epithelial Skinsupporting

confidence: 78%

Expression Levels of the microRNA Processing Enzymes Drosha and Dicer in Epithelial Skin Cancer

Sand

Gambichler

Skrygan

et al. 2010

Cancer Investigation

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“…Cervical cancer follow-up includes physical examination, vaginal inspection/colposcopy and Pap smear, every 3 mo for a total of 2 years and then less often [41] . When there are suspicious findings, vaginal biopsy is performed.…”

Section: Guidelines For Cervical Cancer Follow-up (Ct Mri Pet-ct)mentioning

confidence: 99%

Current imaging strategies for the evaluation of uterine cervical cancer

Bourgioti

Chatoupis

Moulopoulos

2016

WJR

104

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Uterine cervical cancer still remains an important socioeconomic issue because it largely affects women of reproductive age. Prognosis is highly depended on extent of the disease at diagnosis and, therefore, accurate staging is crucial for optimal management. Cervical cancer is clinically staged, according to International Federation of Gynecology and Obstetrics guidelines, but, currently, there is increased use of cross sectional imaging modalities [computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-CT (PET-CT)] for the study of important prognostic factors like tumor size, parametrial invasion, endocervical extension, pelvic side wall or adjacent/distal organs involvement and lymph node status. Imaging indications also include cervical cancer follow-up, evaluation of tumor response to treatment and selection of suitable candidates for less radical surgeries like radical trachelectomy for fertility preservation. The preferred imaging method for local cervical cancer evaluation is MRI; CT is equally effective for evaluation of extrauterine spread of the disease. PET-CT shows high diagnostic performance for the detection of tumor relapse and metastatic lymph nodes. The aim of this review is to familiarize radiologists with the MRI appearance of cervical carcinoma and to discuss the indications of cross sectional imaging during the course of the disease in patients with cervical carcinoma.

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“…Because most patients’ recurrences are distant, the National Comprehensive Cancer Network guidelines recommend adjuvant chemotherapy as a treatment option in patients diagnosed with early-stage uterine carcinosarcoma [6]. The Gynecologic Oncology Group (GOG) 150 study showed that chemotherapy was associated with better survival than whole abdominal irradiation, but this difference was not statistically significant, and the study included all stages of uterine carcinosarcoma [7].…”

Section: Introductionmentioning

confidence: 99%

Patterns of care, predictors, and outcomes of chemotherapy in elderly women with early-stage uterine carcinosarcoma: A population-based analysis

Garg

Yee

Schwartz

et al. 2014

Gynecologic Oncology

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Objective To examine the patterns of care, predictors, and impact of chemotherapy on survival in elderly women diagnosed with early-stage uterine carcinosarcoma. Methods The Surveillance, Epidemiology, and End Results (SEER)-Medicare database was used to identify women 65 years or older diagnosed with stage I-II uterine carcinosarcoma from 1991 through 2007. Multivariable logistic regression and Cox-proportional hazards models were used for statistical analysis. Results A total of 462 women met the eligibility criteria; 374 had stage I, and 88 had stage II uterine carcinosarcoma. There were no appreciable differences over time in the percentages of women administered chemotherapy for early stage uterine carcinosarcoma (14.7% in 1991–1995, 14.9% in 1996–2000, and 17.9% in 2001–2007, P=0.67). On multivariable analysis, the factors positively associated with receipt of chemotherapy were younger age at diagnosis, higher disease stage, residence in the eastern part of the United States, and lack of administration of external beam radiation (P<0.05). In the adjusted Cox-proportional hazards regression models, administration of three or more cycles of chemotherapy did not reduce the risk of death in stage I patients (HR: 1.45, 95% CI: 0.83–2.39) but was associated with non-significant decreased mortality in stage II patients (HR: 0.83, 95% CI: 0.32–1.95). Conclusions Approximately 15–18% of elderly patients diagnosed with early-stage uterine carcinosarcoma were treated with chemotherapy. This trend remained stable over time, and chemotherapy was not associated with any significant survival benefit in this patient population.

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Uterine Neoplasms

Cited by 67 publications

References 120 publications

Expression Levels of the microRNA Processing Enzymes Drosha and Dicer in Epithelial Skin Cancer

Expression Levels of the microRNA Processing Enzymes Drosha and Dicer in Epithelial Skin Cancer

Current imaging strategies for the evaluation of uterine cervical cancer

Patterns of care, predictors, and outcomes of chemotherapy in elderly women with early-stage uterine carcinosarcoma: A population-based analysis

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