Uterine miR-877-3p and let-7a-5p are increased during simulated menstruation in a mouse model

Watters, Marianne; Walker, Catherine; Murray, Alison; Nicol, M; Maybin, Jacqueline A.

doi:10.1530/raf-21-0112

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…TGFB, have also been detected at lower levels in the premenstrual endometrium of those with HMB ( Maybin et al , 2017 ). Lower menstrual levels of HIF1A and TGFB in patients with AUB-E may affect vascular repair, angiogenesis, and restoration of the luminal epithelial barrier after endometrial shedding ( Lu et al , 2021 ; Watters et al , 2022 ). Further research to increase the underlying cause of AUB in those without structural abnormalities will increase precision in the treatment of this debilitating symptom.…”

Section: Reproductive Tract Abnormalities Caused Linked or Exacerbate...mentioning

confidence: 99%

Cyclic processes in the uterine tubes, endometrium, myometrium, and cervix: pathways and perturbations

Holdsworth-Carson

Menkhorst

Maybin

et al. 2023

Molecular Human Reproduction

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This review leads the 2023 Call for Papers in MHR: ‘Cyclical function of the female reproductive tract’ and will outline the complex and fascinating changes that take place in the reproductive tract during the menstrual cycle. We will also explore associated reproductive tract abnormalities that impact or are impacted by the menstrual cycle. Between menarche and menopause, women and people who menstruate living in high-income countries can expect to experience ∼450 menstrual cycles. The primary function of the menstrual cycle is to prepare the reproductive system for pregnancy in the event of fertilization. In the absence of pregnancy, ovarian hormone levels fall, triggering the end of the menstrual cycle and onset of menstruation. We have chosen to exclude the ovaries and focus on the other structures that make up the reproductive tract: uterine tubes, endometrium, myometrium, and cervix, which also functionally change in response to fluctuations in ovarian hormone production across the menstrual cycle. This inaugural paper for the 2023 MHR special collection will discuss our current understanding of the normal physiological processes involved in uterine cyclicity (limited specifically to the uterine tubes, endometrium, myometrium, and cervix) in humans, and other mammals where relevant. We will emphasize where knowledge gaps exist and highlight the impact that reproductive tract and uterine cycle perturbations have on health and fertility.

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Section: Reproductive Tract Abnormalities Caused Linked or Exacerbate...mentioning

confidence: 99%

Cyclic processes in the uterine tubes, endometrium, myometrium, and cervix: pathways and perturbations

Holdsworth-Carson

Menkhorst

Maybin

et al. 2023

Molecular Human Reproduction

Self Cite

View full text Add to dashboard Cite

show abstract

Uterine miR-877-3p and let-7a-5p are increased during simulated menstruation in a mouse model

Abstract: N/A for research letter

Cited by 1 publication

References 7 publications

Cyclic processes in the uterine tubes, endometrium, myometrium, and cervix: pathways and perturbations

Cyclic processes in the uterine tubes, endometrium, myometrium, and cervix: pathways and perturbations

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