Uterine Metastasis from a Heterologous Metaplastic Breast Carcinoma Simulating a Primary Uterine Malignancy

Sinkre, Prasanna; Milchgrub, Sara; Miller, David S.; Albores‐Saavedra, Jorge; Hameed, Arif

doi:10.1006/gyno.1999.5712

Cited by 13 publications

(5 citation statements)

References 5 publications

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“…Lobular infiltrating carcinoma of the breast is the histological type that most frequently metastasizes to the uterus [2,4,6]. However, infiltrating ductal carcinoma of the breast has also been reported to metastasize to the uterine corpus [7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer Masquerades as an Endometrial Cancer

Akinpeloye¹

2017

Obstet Gynecol Cases Rev

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Section: Discussionmentioning

confidence: 99%

Breast Cancer Masquerades as an Endometrial Cancer

Akinpeloye¹

2017

Obstet Gynecol Cases Rev

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“…Breast is the most common primary carcinoma seen in uterus followed by, stomach, cutaneous malonoma, lung, colon, pancreas and kidney [1][2][3]. Endometrial involvement, when present, can be a component of diffuse metastasis of a disseminated cancer [11,[14][15][16] and endometrial involvement is usually diffuse sparing the glands [1]. But isolated metastatic foci can also be seen in endometrial polyps, but these are as case reports in the literature and summarized in the table 1.…”

Section: Discussionmentioning

confidence: 99%

Breast carcinoma metastasis to endometrial polyp (Case report and literature review)

Türkmen¹,

Başsüllü²,

Yaşar³

et al. 2013

CMJ

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Metastasis to female genital tract are most commonly seen in the ovaries and it is very rare for uterus to have metastasis from extragenital organs. Metastatic carcinoma in an endometrial polyp is exceptional and presented as case reports in the literature. The presented case was a 52 year old woman, having metastatic breast carcinoma of invasive ductal type. She admitted to the gynecology department, with the complaint of postmenapausal bleeding. The pathological examination revealed a hyperplastic endometrial polyp, having a focus of epiteloid cellular infiltration in the stroma. The immunohistochemical staining showed these cells to be CD 10 negative, Pancytkeratin and GCDFP-15 positive. Pathological diagnosis was hyperplastic polyp, with focal carcinoma infiltration (compatible with breast carcinoma). The curettage specimens of the patients being followed for breast carcinoma is frequently seen in the daily routine of the pathology. The probability of metastatic disease must be kept in mind and the whole curretage materials must be evaluated. The pathological examination must be carefully made for the exclusion of a metastatic carcinoma. Keywords: Endometrium, metastasis, breast carcinoma, endometrial polyp Özet Kadın genital sistemde metastazlar en sık overlerde görülür ve uterus için ekstragenital organlar dışından metastaz alımı çok nadirdir. Endometrial polipe metastaz ististani bir durum olup, literatürde olgu sunumları şeklinde yer almaktadır. Sunulan olgu 52 yaşında, metastatik invaziv duktal tip meme karsinomu olan kadın hastadır. Hasta jinekoloji bölümüne postmenapozal kanama şikayeti ile başvurdu. Patolojik incelemede hiperplastik tipte endometrial polip ve fokal bir alanda stroma içinde epiteloid hücre infiltrasyonu izlendi. İmmunohistokimyasal incelemede bu hücrelerin CD10 negatif, Pansitokeratin ve GCDFP-15 ile pozitif olduğu görüldü. Patolojik tanı fokal karsinom infiltrasyonu (meme kanseri ile uyumlu) içeren hiperplastik polip olarak raporlandı. Meme karsinomu tanısı ile takip edilen hastalara ait küretaj materyalleri patoloji rutininde sıkça yer almaktadır. Metastatik hastalık olasılığı akılda tutulmalı, materyalin tamamı incelemeye alınmalı ve patolojik inceleme; metastatik hastalığı ekarte etmek üzere dikkatle yapılmalıdır. Anahtar sözcükler: Karsinoma, duktal, meme, tümör metastazı, endometriyal tümörler Geliş tarihi

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“…Some authors have proposed hypercalcemia, hyperoesterinism, dystrophic calcification, and iatrogenic impactation of fetal parts as other possible mechanisms of cartilage formation in the endometrium (Madiwale et al, 2001;Sethi et al, 2008). We are however of the opinion that such metaplastic changes are likely to be associated with osseous endometrial adenocarcinoma (Nicolae et al, 2011), and metastatic tumours with mesenchymal components such as metaplastic breast carcinoma (Sinkra et al, 2000).…”

Section: Introductionmentioning

confidence: 96%

Endometrial metaplasia in a grand multiparous Nigerian woman; A case report with a review of literature

Uchendu

Uchenu

Sokoh

et al. 2022

jcbr

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Metaplasia is the substitution of one class of differentiated somatic cell with another differentiated somatic cell in the same tissue. It is an adaptive response to injurious agents, ranging from microbial to environmental causes. Two classes of metaplasia have been documented in the endometrium, the more common epithelial metaplasia and the rare mesenchymal metaplasia. Both types have vast morphological forms and may occur in isolation or co-exist with one another. They are frequently overlooked and are major diagnostic pitfalls. Careful clinical and histopathological evaluation are therefore pertinent to avoid over-diagnosis or misdiagnosis. Herein, we report a rare case of cartilaginous metaplasia co-existing with endometrial gland clear cell change in a 45-year old multiparous Nigerian woman, who presented with multiple endometrial polyp.

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Uterine Metastasis from a Heterologous Metaplastic Breast Carcinoma Simulating a Primary Uterine Malignancy

Cited by 13 publications

References 5 publications

Breast Cancer Masquerades as an Endometrial Cancer

Breast Cancer Masquerades as an Endometrial Cancer

Breast carcinoma metastasis to endometrial polyp (Case report and literature review)

Endometrial metaplasia in a grand multiparous Nigerian woman; A case report with a review of literature

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