Uterine liposarcoma in a young woman: a case report

Abstract

Liposarcoma of uterus is a very rare neoplasm encountered generally in the sixth or seventh decade of life. We reported the eighth case of uterine liposarcoma with extension to broad ligament in a 23-year-old woman who presented with pelvic pain, dysuria, and rapidly enlarging pelvic mass. During laparotomy, the mass was detected to be originated from the uterine cervix. In frozen section, no definitive diagnosis was established, and for preservation of fertility, extirpation of the mass was performed. The histopathologic examination of the specimen revealed liposarcoma. The tumor cells were diffusely and intensively immune reactive for vimentin and S-100, and negative for smooth muscle actin, desmin, h-caldesmon, pan cytokeratin, and CD10. Staining with periodic acid and Schiff, alcian blue, mucicarmine, and epithelial membrane antigen (EMA) were negative. No recurrence was detected in the postoperative seventh month. Present case is the youngest patient with uterine liposarcoma and also the first case detected in reproductive period.

Liposarcoma Arising in Uterine Lipoleiomyoma

“…Abnormal vaginal bleeding was the most common presentation, 4,14,25,31,41,43 and other symptoms included pelvic pain, increasing abdominal girth, dysuria, weight loss, and constipation. 4,14,18,20,39 Only 1 of 3 of our patients presented with uterine bleeding. The diagnoses of the previously reported 10 uterine liposarcomas were based strictly on histopathologic and immunohistochemical findings.…”

“…To date, 10 cases within the uterus 4,14,18,20,25,31,32,39,41,43 have been described in the literature. Patients with uterine liposarcomas have ranged in age from 23 to 78 (mean, 56) years, which is similar to the age range found in our patients.…”

“…Liposarcoma rarely involves the female genital tract and in this region it most frequently develops within the uterus with 10 cases having been reported. 4,14,18,20,25,31,32,39,41,43 Of these, 2 arose in association with a leiomyoma.…”

Concomitant Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Broad Ligament and Endometrioid Endometrial Adenocarcinoma

“…5 In this case, the tumor was totally separated from the uterus and arose within the leaves of the broad ligament and, therefore, could not be labelled as a uterine liposarcoma. The tumor margins were free.…”

Sarcomas of the Uterine Cervix: A United and Multidisciplinary Approach is Required

“…In a review of the literature, Karateke et al identified five cases of pure liposarcoma origi nating from the cervix including their own case [21]. Two were pleomorphic, one was round cell, one was well differentiated, and one was round and myxoid.…”