Uterine lipoleiomyoma and lipoma: A rare unique case report with review of literature

Abstract

Uterine lipoleiomyoma and pure lipoma are uncommon and extremely rare benign lipomatous tumors. Reported incidence is 0.03%–0.25%. Pure cervical lipoma is exceptionally rare. These tumors commonly arise in postmenopausal women. Ultrasonography and computed tomography finding may be nonspecific. Although magnetic resonance imaging can be useful in identifying the fatty nature of the lesion preoperatively, most of the cases postoperatively on histopathological examination. Although various theories of histogenesis of these tumors have been proposed, histogenesis remains to be enigma. These lesions may have coexistent malignancy in uterus, ovaries, and fallopian tubes or may have other metabolic disorders and abnormal estrogen status. Immunohistochemical studies have played an integral role in understanding its complex histogenesis. We did not find any case study in medical literature in which uterine lipoleiomyoma and cervical lipoma have been described in hysterectomy specimen. We report a unique case of a 43-year-old premenopausal woman with complaints of irregular vaginal bleeding and lower abdomen pain. Lipoleiomyoma in uterus corpus and cervical lipoma were diagnosed in hysterectomy specimen.

A Large Pure Uterine Lipoma: Its Diagnosis by Pelvic MRI and Histopathology

“…They are very rare in occurrence and their exact incidence is not yet known. As in our case, the patient population usually affected are postmenopausal women over the age of 50 years [5], with some cases reported in women in their 40s [4]. Uterine lipomas are usually solitary lesions, mostly located in the body of the uterus.…”

“…They are most intramural as seen in our patient; however, submucosal and subserosal tumors have been described [3,5]. Although uterine lipomas are difficult to diagnose by imaging, pelvic MRI can be useful in identifying the fatty nature of these lesions [4]. Previous studies have suggested that MRI is the best modality of radiological investigation for preoperative diagnosis [8].…”

“…Since only a few cases have been reported, the exact incidence is still not known. Moreover, given the nonspecific findings on pelvic ultrasound and CT [3,4], they can often be misdiagnosed with other types of neoplasms [5].…”

“…Malignant conversion of these tumors is rare. Given these characteristics, they are usually diagnosed incidentally [4,6]; however, they can sometimes present with nonspecific symptoms such as abdominal pain and/or vaginal bleeding [2,7]. Uterine lipomas are commonly found in the body of the uterus and measure approximately 5-10 cm in size [3,5,8].…”

Uterin lipoma, leiyomyoma ve endometrial polip birlikteliği

“…muscle cells into fat cells. However, Akyıldız et al reported a case of pure uterine lipoma in which fat cells were positive for S-100 and negative for SMA 15 .…”