Uterine Leiomyosarcoma

Juhasz-Böss, Ingolf; Gabriel, Lena; Bohle, Rainer M.; Horn, Lars Christian; Solomayer, Erich‐Franz; Breitbach, G. P.

doi:10.1159/000494299

Cited by 49 publications

(50 citation statements)

References 43 publications

(53 reference statements)

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“…ULMS is a highly malignant tumor with poor outcome (low ve-year survival rate and high recurrence rate) [37]. To date, no safe and effective medications for uterine leiomyosarcoma have been developed [38,39], it is imperative to nd effective medicine for this disease.…”

Section: Discussionmentioning

confidence: 99%

Curdione induces G2/M phage arrest, apoptosis and autophagy via COX2 mediate IDO1 expression through PKCδ/ GSK3β/β-catenin pathway in human uterine leiomyosarcoma

Wei

Wang

et al. 2020

Preprint

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Background Curdione, one of active ingredients of a traditional Chinese herb medicine-Curcuma zedoary, has been reported with beneficial therapeutic effects in lots of cancer types. However, the potential anti-cancer effect in uterine leiomyosarcoma (uLMS) and the underlying mechanisms are still unclear.Methods The aim of this study was to explore the potential effect and mechanisms of curdione on uLMS in vitro and vivo with uLMS cell lines and mouse xenograft tumor model respectively.Results Curdione triggered anti-proliferation effect in uLMS cell lines by inducing cell cycle arrest at G2/M phase, caspase-mediated cell apoptosis, and pro-death cell autophagy. Indoleamine-2,3-dioxygenase-1 (IDO1), which was dependent on cyclooxygenase-2 (COX2), mediated the anti-proliferation effect of curdione. Curdione down-regulated IDO1 expression and promoted the dephosphorylation of protein kinase c (PKC), glycogen synthase kinase-3 beta (GSK3β) and β-catenin in cell lines. PKC/GSK3β/β-catenin pathway responsible for constitutive IDO1 expression in uLMS. COX2 mediate the promotion effect of curdione on the PKC/GSK3β/β catenin pathway activity, which was detected by COX2 inhibitor, and further confirmed by COX2 siRNA and COX2 overexpression. The pathway activity was inhibited by COX2-siRNA and enhanced by COX2 overexpression. In turn, the pathway inhibitor suppressed IDO1 expression. The anti-proliferation effect of curdione on uterine leiomyosarcoma were further confirmed in vivo. Echoing to the results in vitro, the underline mechanism involved in COX2-mediated IDO1 down-regulation via PKCδ/GSK3β/β-catenin pathway.Conclusion COX2-mediated IDO1 down-regulation via PKCδ/GSK3β/β-catenin pathway involved in the anti-proliferation effect of curdione on uterine leiomyosarcoma in vitro and vivo.

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Section: Discussionmentioning

confidence: 99%

Curdione induces G2/M phage arrest, apoptosis and autophagy via COX2 mediate IDO1 expression through PKCδ/ GSK3β/β-catenin pathway in human uterine leiomyosarcoma

Wei

Wang

et al. 2020

Preprint

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“… 5 , 9 LMS is rarely suspected before surgery and is often detected by histopathology after hysterectomy or myomectomy, with or without morcellation. 4 Unintended morcellation of occult LMS results in a grave prognosis. 10 Preoperative diagnostic differentiation between LMS and DUF is therefore very important.…”

Section: Introductionmentioning

confidence: 99%

“…2 LMS has non-specific symptoms, is aggressive and has high recurrence rates, and thus, patients with LMS have a poor prognosis, even if the disease is detected and treated at an early stage. [2][3][4] Uterine leiomyomas (uterine fibroids) are the most common solid, benign gynecological tumor. 5 In conventional magnetic resonance imaging (MRI), a typical leiomyoma exhibits low signal intensities in T1-weighted images (T1WIs) and T2-weighted images (T2WIs).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Preoperative CA125, LDH and HE4 for Leiomyosarcoma of the Female Reproductive System

Zhang¹,

Liu²,

Quan³

et al. 2021

CMAR

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Purpose Leiomyosarcoma (LMS) is a rare and extremely aggressive malignancy that is derived from or shows evidence of differentiation toward smooth muscle. If LMS occurs in the female reproductive system, preoperative diagnosis can be difficult, as LMS is easily mistaken for a uterine leiomyoma, especially a degenerated uterine fibroid (DUF). Thus, we assessed the diagnostic value of the preoperative serum concentrations of cancer antigen 125 (CA125), lactate dehydrogenase (LDH) and human epididymis protein 4 (HE4) for differentiating LMS from DUF. Patients and Methods We enrolled patients with LMS or DUF who were receiving treatment in The First Affiliated Hospital of Chongqing Medical University between 2009 and 2020. If the preoperative serum concentrations of CA125, LDH and HE4 of our study participants had been tested, these data were analyzed. The preoperative serum concentrations of CA125, LDH and HE4 in participants with LMS (n = 37) were compared with those of participants with pathologically diagnosed DUF (n = 102), who served as the control group. Results The preoperative serum concentrations of CA125, LDH and HE4 of participants with LMS of the female reproductive system were significantly higher than those of participants with DUF ( P = 0.009, P < 0.001, P = 0.001, respectively). The cut-off preoperative serum concentrations of CA125, LDH and HE4 were 30.85 U/mL, 186.50 U/L and 50.50 pmol/L, respectively. When these three parameters were used for an analysis of their combined diagnostic utility, the area under the curve (AUC) was 0.892, the sensitivity was 68.4% and the specificity was 95.1% ( P < 0.001). Conclusion A combined analysis of the preoperative serum concentrations of CA125, LDH and HE4 could be a promising method for diagnostically differentiating LMS of the female reproductive system from DUF.

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“…and the highest prevalence in the pre-and menopause period. Only early-stage tumors have an acceptable prognosis, provided the patient has been treated without injuring the uterus [2]. In contrast to endometrial carcinomas which most commonly metastasize to the lymph nodes, ULMS has a high propensity for hematogenous spread most commonly to the lungs [3].…”

Section: Introductionmentioning

confidence: 99%

Brain Metastasis of Uterine Leiomyosarcoma: A Case Report and Review of the Literature

Imoumby¹,

Dokponou²,

Kouakou³

et al. 2021

OJMN

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The metastases of uterine leiomyosarcoma to the brain are exceptional and such cases are seldomly reported in the literature. The diagnosis is based on CT and brains MRI findings, in association with a gynecological history of cancer. Their management still stays without guidelines, and the surgical total resection is known to be the only way to influence positively the prognosis and save patient lives. We report a rare case of a 46 years old woman who underwent a hysterectomy and bilateral salpingo-oophorectomy 5 years earlier and presented with the right hemiparesis and whose CT scan and MRI of the brain showed cerebral lesions related to brain location of uterine leiomyosarcoma. The patient underwent surgery for gross total tumor resection, followed by adjuvant radiotherapy, and was doing well after surgery. Three months later she was admitted for recurrences and died after two months of palliative care.

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Uterine Leiomyosarcoma

Cited by 49 publications

References 43 publications

Curdione induces G2/M phage arrest, apoptosis and autophagy via COX2 mediate IDO1 expression through PKCδ/ GSK3β/β-catenin pathway in human uterine leiomyosarcoma

Curdione induces G2/M phage arrest, apoptosis and autophagy via COX2 mediate IDO1 expression through PKCδ/ GSK3β/β-catenin pathway in human uterine leiomyosarcoma

Diagnostic Value of Preoperative CA125, LDH and HE4 for Leiomyosarcoma of the Female Reproductive System

Brain Metastasis of Uterine Leiomyosarcoma: A Case Report and Review of the Literature

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