Uterine leiomyoblastoma

Mulita, Francesk; Iliopoulos, Fotios; Plachouri, Kerasia‐Maria; Kehagias, Ioannis

doi:10.1136/bcr-2020-241533

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…As the most common symptom of a uterine tumor is abnormal uterine bleeding, it is very important to differentiate endometrial cancer at early stages from endometrial hyperplasia and endometrial polyps and also to differentiate advanced stages of cancer from uterine sarcoma or uterine lymphoma [ 10 , 11 ]. Endometrial hyperplasia is an overgrowth of the endometrium which usually causes heavy or abnormal bleeding.…”

Section: Discussionmentioning

confidence: 99%

An enormous pelvic tumor in a 46-year-old woman with an elevated serum CA 125 level, what lies beneath it? Investigation of uterine tumors in postmenopausal women

Mulita¹,

Liolis²,

Kehagias³

et al. 2021

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Abdominal and pelvic pain with an associated pelvic mass is a very common emergency situation. There is always a management dilemma for most emergency physicians regarding these patients. A 46-year-old postmenopausal woman was admitted to our emergency department (ED) with complaints of massive abdominal distention. Abdominal and pelvis magnetic resonance imaging (MRI) was performed, which revealed a huge pelvic abdominal mass. All tumor markers were within normal limits. However, the ovarian cancer antigen (CA 125) level was elevated. As there was a strong suspicion of malignancy, the patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy. Her final histopathology report was suggestive of uterine leiomyoma. Uterine leiomyomas are the most common benign uterine tumors in women. Surgical treatment is the gold standard, especially for older women with severe symptoms and no desire for future fertility. Although the combination of a pelvic tumor and a high-level of CA 125 arouses suspicion of gynecological malignancy, other benign conditions should always be considered in the differential diagnosis. There is limited evidence to support an association between elevated CA 125 levels and uterine fibroids so far. However, conditions such as the coexistence of adenomyosis and tumor size can affect the level of this marker in uterine fibroids.

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Section: Discussionmentioning

confidence: 99%

An enormous pelvic tumor in a 46-year-old woman with an elevated serum CA 125 level, what lies beneath it? Investigation of uterine tumors in postmenopausal women

Mulita¹,

Liolis²,

Kehagias³

et al. 2021

Self Cite

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show abstract

“…Myomectomy, which involves the removal of the fibroid while preserving the uterus, is a preferred option for women who desire fertility. Hysterectomy, which involves the removal of the uterus, is recommended for women who have completed childbearing or have severe symptoms, such as leiomyoblastoma, and do not desire fertility [ 13 , 14 ]. Salpingectomy, the removal of the fallopian tubes, is performed in cases of large or complex ovarian cysts, suspected malignancy, or risk reduction in women at elevated risk of ovarian cancer [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-Guided Diagnosis of Multiple Uterine Fibroids in a Patient With Polycystic Ovaries and Treatment With Relugolix, Estradiol, and Norethisterone Acetate

Acchiardo,

Maita,

Jobanputra

2023

Cureus

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Uterine fibroids and ovarian cysts are common gynecological conditions that, while benign, when present simultaneously with bacterial vaginosis, can present a more complicated course of management. Symptoms of uterine fibroids include menorrhagia and dysmenorrhea, while ovarian cysts may present with pelvic pain and an adnexal mass. Each condition is typically managed separately; however, they can coexist in some patients, leading to a more complex presentation. This case report presents a 35-year-old African American female patient with the simultaneous occurrence of uterine fibroids and ovarian cysts, complicated by recurrent vaginitis, along with the treatment approach. The treatment choice, relugolix, estradiol, and norethisterone (norethindrone) acetate, is the first once-daily U.S. Food and Drug Administration (FDA) combination hormonal medication approved for menorrhagia due to fibroids. This case is unique in that although the diagnoses are common, their coexistence makes for a more complex presentation, and the course of management presents a newly approved fixed-dose combination hormonal medication. This report discusses the incidence, pathophysiology, diagnosis, and management of uterine fibroids and ovarian cysts. Factors that may contribute to the concurrence of these conditions, such as genetic, hormonal, and environmental risks, are also explored. Diagnostic modalities and ultrasound techniques are reviewed, and treatment options, such as surgery and medical management, are discussed. The importance of a patient-centered approach in the treatment of multi-symptom gynecological disorders and the need to consider conservative management are emphasized.

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“…However, awareness of tumor variants and unconventional growth patterns is critical for appropriate classification and patient management. Pathological findings have been reported in a few cases of uterine epithelioid leiomyoma [ 2 ]. However, MRI findings of this rare tumor have not been reported.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid leiomyoma of the uterus: A case report with magnetic resonance imaging findings

Kita

Maeda

Kitajima

et al. 2022

Case Reports in Women's Health

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Uterine leiomyoblastoma

Cited by 7 publications

References 6 publications

An enormous pelvic tumor in a 46-year-old woman with an elevated serum CA 125 level, what lies beneath it? Investigation of uterine tumors in postmenopausal women

An enormous pelvic tumor in a 46-year-old woman with an elevated serum CA 125 level, what lies beneath it? Investigation of uterine tumors in postmenopausal women

Ultrasound-Guided Diagnosis of Multiple Uterine Fibroids in a Patient With Polycystic Ovaries and Treatment With Relugolix, Estradiol, and Norethisterone Acetate

Epithelioid leiomyoma of the uterus: A case report with magnetic resonance imaging findings

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