Uterine immune profiling for increasing live birth rate: A one-to-one matched cohort study

Lédée, Nathalie; Prat-Ellenberg, Laura; Chevrier, L.; Balet, R.; Simon, Cynthia; Lenoble, Clarisse; Irani, Elie El; Bouret, Dominique; Cassuto, Nino Guy; Vitoux, Dominique; Vezmar, Katia; Bensussan, Armand; Chaouat, G.; Petitbarat, Marie

doi:10.1016/j.jri.2016.11.007

Cited by 45 publications

(21 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Initially developed in France for patients with a history of repeated implantation failures (RIF) (25,26), we describe here the clinical results observed in 1,738 infertile patients and document its efficacy in clinical settings other than those previously studied as good prognosis infertile patients, patients with recurrent miscarriages or oocyte recipients. Between 2012 and 2018, based on the 1,738 documented immune profiles, suggestions of personalized care were proposed to the clinician, to be applied within the next 6 months or at the subsequent embryo transfer.…”

Section: Introductionmentioning

confidence: 74%

“…IL-15/Fn-14 and IL-18/TWEAK mRNA ratios were determined by quantitative RT-PCR with the Light Cycler 480 SYBR Green I Master mix (Roche Diagnostic). uNK cells recruitment was initially assessed using immunochemistry labeling positive CD56 cells and is currently assessed by Real time PCR (25,26).…”

Section: Endometrial Biopsy: Collection and Analysismentioning

confidence: 99%

“…The local immune profile was defined according to the local balance of the mRNA expression of the two ratios IL-18/TWEAK, IL-15/Fn-14, and CD56 immunostaining or mRNA expression (25,26).…”

Section: Diagnosis Of Endometrial Immune Profilementioning

confidence: 99%

See 2 more Smart Citations

Endometrial Immune Profiling: A Method to Design Personalized Care in Assisted Reproductive Medicine

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 74%

Section: Endometrial Biopsy: Collection and Analysismentioning

confidence: 99%

See 1 more Smart Citation

Endometrial Immune Profiling: A Method to Design Personalized Care in Assisted Reproductive Medicine

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the endometrium as well, IL-15 is the central cytokine for the uNKs recruitment and maturation enabling them to acquire their effective pro-implantation functions (17,18). Similarly, our team has described variable levels of endometrial IL-15 in groups of patients with repeated implantation failure when compared to the controls (19).…”

Section: Immune Rationale: Endometrial Inflammation and Embryo Implanmentioning

confidence: 82%

Targeted Endometrial Scratching: An Example of Endometrial Diagnosis Usage in Reproductive Medicine

Rahmati

Lédée

2020

Front. Immunol.

Self Cite

View full text Add to dashboard Cite

“…Although several preclinical/animal studies show promising results, 10–13 these options must now be tailored to achieve targeted, safe immunotherapy both as prevention and therapy for pregnancy complications. Moreover, since a range of factors, including non-immune related, is implicated in pregnancy complications, 14 selection of the right patients will be essential for the success of therapy. 5 15 …”

Section: Introductionmentioning

confidence: 99%

Development of a core outcome set for immunomodulation in pregnancy (COSIMPREG): a protocol for a systematic review and Delphi study

et al. 2018

View full text Add to dashboard Cite

IntroductionTo establish pregnancy, the maternal immune system must adapt to tolerate the semiallogenic fetus. Less than optimal adaptation of the maternal immune system during (early) pregnancy is implicated in several complications of pregnancy. The development of effective immune modulation interventions as preventive or therapeutic strategies for pregnancy complications holds promise. Several studies sought to evaluate the safety and effectiveness of various approaches. However, a limitation is the high variability in clinical and immune outcomes that are reported. We, therefore, aim to develop a core outcome set for application to studies of immune modulation in pregnancy (COSIMPREG).Methods and analysisWe will use a stepwise approach to develop a COSIMPREG. First, we will perform a systematic review to identify reported outcomes. For this review, Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines will be followed. Second, we will use the Delphi method to develop a preliminary COSIMPREG. In three rounds, the outcomes of the systematic review will be scored. A panel comprising experts from relevant disciplines and diverse geographical locations will be assembled until a sufficient quality of the panel is reached. We will use predefined decision rules for outcomes. After each round outcomes, including scores, will be returned to the panel for further refinement. The outcomes not excluded after the third round will be taken to a consensus meeting. In this meeting, experts from all relevant disciplines will discuss and finalise the COSIMPREG.Ethics and disseminationFor this study ethical approval is not required. The systematic review will be published in an appropriate open access reproductive immunology journal. Once the COSIMPREG is finalised, it will be published in an open access reproductive immunology journal, and disseminated at appropriate international meetings, as well as through relevant research and scientific societies. Experts involved in the Delphi study will be asked to give informed consent.

show abstract

Uterine immune profiling for increasing live birth rate: A one-to-one matched cohort study

Cited by 45 publications

References 31 publications

Endometrial Immune Profiling: A Method to Design Personalized Care in Assisted Reproductive Medicine

Endometrial Immune Profiling: A Method to Design Personalized Care in Assisted Reproductive Medicine

Targeted Endometrial Scratching: An Example of Endometrial Diagnosis Usage in Reproductive Medicine

Development of a core outcome set for immunomodulation in pregnancy (COSIMPREG): a protocol for a systematic review and Delphi study

Contact Info

Product

Resources

About