Uterine fibroids: A clinical review

Vollenhoven, Beverley; Lawrence, Anthony; Healy, David

doi:10.1111/j.1471-0528.1990.tb01804.x

Cited by 317 publications

(156 citation statements)

References 47 publications

(10 reference statements)

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“…Increasing age is a risk factor for fibroid growth. 12 Several studies on the incidence of myoma have been carried out in different localities by different researchers around the world and they observed that the incidences obtained varied with the sample size and population studied. In Poland for instance, Batoniak et al 4 evaluated 670 women and obtained an incidence of 24%.…”

Section: Discussionmentioning

confidence: 99%

Sonographic assessment of pregnancy co-existing with uterine leiomyoma in Owerri, Nigeria

Eze¹,

Odumeru²,

Ochie³

et al. 2013

Afr H. Sci.

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Background: Uterine myomas co-existing with pregnancy could cause obstetric complications. Objectives: To assess sonographically the frequency of occurrence and effect of uterine myomas co-existing with pregnancy. Methods: A longitudinal study was conducted during a period of 23 months. A convenience sample of 816 consecutive consenting pregnant women who met the inclusion criteria was evaluated during routine prenatal ultrasound scan. The women were referred for prenatal sonography. One hundred of the subjects who had myoma co-existing with pregnancy and another 100 subjects without myoma were selected for follow-up. These groups were followed up till delivery and obstetric complications and outcomes were documented. Any changes in size and growth rate of myoma were documented. Results: Subjects with myoma co-existing with pregnancy were 12.3%. This was commoner with increasing maternal age. An increase was observed in myoma mean size from 60mm to 63mm from the 1 st scan sequence to the 2 nd scan sequence and a reduction from 63mm to 59mm in the 3 rd scan sequence. Myoma growth rate was 0.667mm per week. Myomas in pregnancy especially large ones caused more complications during delivery when compared to pregnancies without myomas. Conclusion: Routine sonography is important in pregnancy management of uterine myomas co-existing with pregnancy.

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Section: Discussionmentioning

confidence: 99%

Sonographic assessment of pregnancy co-existing with uterine leiomyoma in Owerri, Nigeria

Eze¹,

Odumeru²,

Ochie³

et al. 2013

Afr H. Sci.

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“…Leiomyomas are common tumors found in the uterus and are present in 25% of women of reproductive age [1]. Incidence rates of more than 80% have been reported in asymptomatic women evaluated by ultrasound examination [2].…”

Section: Introductionmentioning

confidence: 99%

Angiomyoma of the uterus: case report and review of literature

et al. 2007

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Angiomyomas of the uterus are uncommon tumors that apparently arise from the smooth muscles of blood vessels. We describe here an unusually large angiomyoma of the uterus in a 45-year-old woman who presented with an abdominal lump. An exploratory laparotomy was followed by a pan-hysterectomy. The dissected section of the uterus showed a huge fleshy mass measuring 20 cm with areas of hemorrhage. Histopathological examination showed many dilated vascular spaces amidst smooth muscle bundles, which is characteristic of cavernous angiomyoma of the uterus.

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“…In humans, uterine leiomyomas, commonly called fibroids, are a significant problem for women of reproductive age (Stewart, 2001;Vollenhoven et al, 1990). These represent the most common genital tract tumor of women over the age of 30 years, with a reported incidence as high as 77% among American women (Cramer and Patel, 1990).…”

Section: Introductionmentioning

confidence: 99%

Uterine Smooth Muscle Tumors in Potbellied Pigs (Sus scrofa) Resemble Human Fibroids: A Potential Animal Model

2004

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Uterine leiomyomas, commonly termed fibroids, clinically affect approximately 25% of women of reproductive age in the United States, with a subclinical incidence as high as 77%. The pathogenesis of fibroid formation remains poorly understood, due in large part to the lack of a suitable animal model. This retrospective study characterizes the clinical, gross, and histopathologic features of similar, spontaneously occurring uterine tumors in potbellied pigs. Medical records available through a local Potbellied Pig Spay/Neuter Program, pig sanctuaries, and the Duchess Fund database were reviewed for evidence of reproductive disease or surgery. One-hundred and six female potbellied pigs were evaluated and uterine neoplasia was identified in 17 animals; tissues were available for 13 of these. Uterine leiomyoma was diagnosed in 11 of 13 cases, leiomyosarcoma in 1 of 13 cases, and undifferentiated sarcoma in 1 case. Pigs presented with clinical signs including abdominal distension or vaginal bleeding or were subclinical and identified during ovariohysterectomy. Tumors ranged from microscopic to 45 kg, were often multiple, and primarily involved the uterine horns. Hematoxylin and eosin and trichrome-stained sections were evaluated for morphological features of human and animal leiomyomas; immunohistochemistry to detect smooth muscle actin was also performed. The cellular pattern/morphology and variable degree of fibroplasia of the leiomyomas were similar to that reported for human fibroids. These results support further investigation of uterine leiomyomas in potbellied pigs as a potentially valuable animal model for studying human fibroids.

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Uterine fibroids: A clinical review

Cited by 317 publications

References 47 publications

Sonographic assessment of pregnancy co-existing with uterine leiomyoma in Owerri, Nigeria

Sonographic assessment of pregnancy co-existing with uterine leiomyoma in Owerri, Nigeria

Angiomyoma of the uterus: case report and review of literature

Uterine Smooth Muscle Tumors in Potbellied Pigs (Sus scrofa) Resemble Human Fibroids: A Potential Animal Model

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