Uterine Factor Infertility, a Systematic Review

Sallée, Camille; Margueritte, François; Marquet, Pierre; Piver, P.; Aubard, Y.; Lavoué, Vincent; Dion, Ludivine; Gauthier, Tristan

doi:10.3390/jcm11164907

Cited by 15 publications

(12 citation statements)

References 163 publications

(184 reference statements)

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“…Green tea is the only antioxidant that has been shown to significantly increase sperm motility, whereas the other two antioxidants investigated, vitamins E and C, did not [231,232]. However, research [233][234][235] shows that vitamin C, catalase, and genistein can reduce DNA damage in sperm that is caused by oxidative stress.…”

Section: Antioxidants and Assisted Reproductive Technologiesmentioning

confidence: 96%

Role of Antioxidants of Natural Herbs in Management of Male Infertility

Gaznee¹,

Kohli²,

Kumar³

2023

J. Res. Appl. Sci. Biotechnol.

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If you and your spouse have been trying to conceive for a year and neither of you has been successful, there is a possibility that you are one of the 50–80 million people throughout the world who struggle with infertility. There is a male component present in approximately 20%-30% of these instances. It is common knowledge that low-quality sperm and oxidative stress (OS) both have a role in the aetiology of male infertility. Because of the oxidation of DNA, proteins, and lipids, excessive levels of reactive oxygen species (ROS) have the potential to disrupt the viability, motility, and morphology of sperm cells. ROS are responsible for these changes. Methods: Through the use of the PubMed interface, we searched the MEDLINE database for studies that had been completed and published during the past ten years that analysed the effect that antioxidants had on sperm in infertile guys (2012–2022). A number of different phrases, including infertility, alpha-lipoic acid, zinc, folate, coenzyme Q10, selenium, and vitamin, were utilised during the search. The study's findings indicate that inositol serves a purpose in a number of different mechanisms that foster contacts between sperm and oocytes, and that it also affects OS levels in sperm cells by way of its engagement in mitochondrial events. Alpha-lipoic acid (ALA) lessens the damage caused by reactive oxygen species (ROS) and improves the quality of sperm in a number of ways, including motility, morphology, and count. There might be a connection between not getting enough zinc in your diet and having low-quality sperm. Zinc and folate are two nutrients that can boost the quantity and quality of sperm. When taken orally, coenzyme Q10 increases the number of sperm as well as their overall motility and forward movement. A therapy with selenium (Se) results in an improvement in the sperm's overall quality, and this improvement is connected with an increase in ejaculatory production. Only vitamin B12 has been found to improve the quality of sperm; it does this by boosting sperm count and motility and by decreasing sperm DNA damage. Vitamin B12 is the only vitamin that has been proved to do this. Conclusions: Dietary supplementation with antioxidants may improve sperm quality in men with low-quality semen by reducing OS-induced sperm damage and increasing hormone synthesis and spermatozoa concentration, motility, and morphology. This may be achieved in men who also have low levels of antioxidants in their semen. Antioxidants can exert their effects in a variety of ways; hence, it is important for researchers conducting future clinical trials to study the possibility of combining a number of antioxidants.

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Section: Antioxidants and Assisted Reproductive Technologiesmentioning

confidence: 96%

Role of Antioxidants of Natural Herbs in Management of Male Infertility

Gaznee¹,

Kohli²,

Kumar³

2023

J. Res. Appl. Sci. Biotechnol.

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“…1,2 Uterine factor infertility of any severity affects approximately 3-5% of the general population 3 and represents 2.1 to 16.7% of women with female infertility. 4 It is estimated that the rate prevalence of AUFI in the UK is around 12 000 women of fertile age. 5 For those women who desire motherhood, uterus transplantation provides an avenue for both gestational and genetic motherhood.…”

Section: Introductionmentioning

confidence: 99%

“…Uterus transplantation is a new treatment for absolute uterine factor infertility (AUFI) 1,2 . Uterine factor infertility of any severity affects approximately 3–5% of the general population 3 and represents 2.1 to 16.7% of women with female infertility 4 . It is estimated that the rate prevalence of AUFI in the UK is around 12 000 women of fertile age 5 .…”

Section: Introductionmentioning

confidence: 99%

Deceased donor availability for uterus transplantation in Australia

Pittman

Abbott

Cavazzoni

et al. 2023

Aust NZ J Obst Gynaeco

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BackgroundUterus transplantation is an emerging treatment option for uterine factor infertility. Most uterus transplantation research programs use living donors, although this comes with considerable surgical and psychological risks and not all women desiring uterus transplantation will have an available living donor. A deceased donor program eliminates donor risks; however, the availability of deceased uterus donors is currently unknown in Australia.AimsTo establish the feasibility of a deceased donor uterus transplantation program in Australia and consider expanded inclusion criteria for this model.Materials and MethodsA retrospective review of the New South Wales (NSW) Organ and Tissue Donation Service database was undertaken to identify potential deceased uterus donors, with comparison to the broad deceased donor inclusion criteria from three international uterus transplantation trials including female, brain‐dead, multi‐organ donation, no major abdominal surgery, and <60 years of age.ResultsBetween January 1, 2018, and December 31, 2022, 648 deceased donors were available in NSW. Of these, 43% (279/648) were female and 67% of the women (187/279) were also multi‐organ donors. When the brain‐dead donor‐only and age criteria (<60 years) were applied, a total of 107 deceased donors met the available criteria for uterus transplantation, with an average of 21 deceased donors per year in NSW.ConclusionsThere appears to be adequate deceased donor organ availability to establish a deceased uterus transplantation program in NSW, Australia. Should interest in uterus transplantation increase, including criteria such as older and nulliparous donors could increase organ availability for a uterus transplantation program.

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“…Similarly, the cause can commonly be obstruction of the tract, testicular failure of spermatogenesis, poor sperm quality, or endocrinal in males [ 3 ]. Uterine factor infertility (UFI) is defined as an absent uterus (absolute UFI) or as a nonfunctional uterus (non-absolute UFI) [ 6 ]. Absolute UFI can be due to congenital absence of the uterus or due to a hysterectomy later [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Basis of Müllerian Agenesis Causing Congenital Uterine Factor Infertility—A Systematic Review

Dube,

Kar,

Jhancy

et al. 2023

IJMS

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Infertility affects around 1 in 5 couples in the world. Congenital absence of the uterus results in absolute infertility in females. Müllerian agenesis is the nondevelopment of the uterus. Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome is a condition of uterovaginal agenesis in the presence of normal ovaries and the 46 XX Karyotype. With advancements in reproductive techniques, women with MA having biological offspring is possible. The exact etiology of MA is unknown, although several genes and mechanisms affect the development of Müllerian ducts. Through this systematic review of the available literature, we searched for the genetic basis of MA. The aims included identification of the genes, chromosomal locations, changes responsible for MA, and fertility options, in order to offer proper management and counseling to these women with MA. A total of 85 studies were identified through searches. Most of the studies identified multiple genes at various locations, although the commonest involved chromosomes 1, 17, and 22. There is also conflicting evidence of the involvement of various candidate genes in the studies. The etiology of MA seems to be multifactorial and complex, involving multiple genes and mechanisms including various mutations and mosaicism.

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Uterine Factor Infertility, a Systematic Review

Cited by 15 publications

References 163 publications

Role of Antioxidants of Natural Herbs in Management of Male Infertility

Role of Antioxidants of Natural Herbs in Management of Male Infertility

Deceased donor availability for uterus transplantation in Australia

Molecular Basis of Müllerian Agenesis Causing Congenital Uterine Factor Infertility—A Systematic Review

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