Uterine cavity evacuation as a novel approach for uterine size reduction during minimal invasive surgery for uterine carcinosarcoma: a report of two cases

Abstract

Background: Uterine carcinosarcoma often presents with significant uterine distention. This makes it difficult to perform minimally invasive surgery, which is preferred for uterine cancer given the significant recovery benefits. Cases: We present two cases of uterine carcinosarcoma in which we performed uterine evacuation intraoperatively to decompress the uterine volume to facilitate specimen removal through the vagina. The first patient ultimately had stage IA disease. She received adjuvant chemotherapy and radiation and has remained disease-free for 2 years. The second patient had stage IVB disease on final pathology report. She received adjuvant chemotherapy but had disease recurrence 4 months after completion of treatment. Conclusion: Intraoperative uterine evacuation during surgery for uterine carcinosarcoma may make possible a minimally invasive procedure in patients with large, distended uteri.

Geldanamycin ameliorates multiple organ dysfunction and microthrombosis in septic mice by inhibiting the formation of the neutrophil extracellular network by activating heat shock factor 1 HSF1

“…Sepsis and septic shock are common critical illnesses in the intensive care unit with a high mortality rate that seriously affect the quality of life of patients. 18,19 As one of the serious complications in clinical acute and critical patients, sepsis can induce septic shock and multiple organ dysfunction syndrome and is often induced by severe trauma, burns, major surgery, infection and other factors. 20,21 The pathophysiological process of sepsis is very complex, including many aspects such as inflammation, immune and coagulation dysfunction.…”