Uterine blood flow during the first 3 weeks of pregnancy in dairy cows

Honnens, Ä.; Voß, Catharina; Herzog, Kathrin; Niemann, Heiner; Rath, Detlef; Bollwein, Heinrich

doi:10.1016/j.theriogenology.2008.06.022

Cited by 45 publications

(35 citation statements)

References 52 publications

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“…The greater E 2 concentration and lesser progesterone concentration beginning on days 15 and 16 respectively in the nonpregnant heifers but not in the pregnant heifers are consistent with previous reports (Ford et al 1979, Honnens et al 2008. The significantly lower progesterone concentration in the nonpregnant group than in the pregnant group on day 16 before the significantly lower cross-sectional CL area and percentage of CL area with blood-flow signals on day 17 agrees with a previous study ).…”

Section: Discussionsupporting

confidence: 92%

“…The significantly lower progesterone concentration in the nonpregnant group than in the pregnant group on day 16 before the significantly lower cross-sectional CL area and percentage of CL area with blood-flow signals on day 17 agrees with a previous study ). The increase in vascularity scores of the endometrium of nonpregnant heifers on days 16-18 was temporally associated with high E 2 and low progesterone concentrations, and it agrees with reports that increased uterine blood flow in nonpregnant heifers is associated with a high oestrogen:progesterone ratio (Ford 1982, Bollwein et al 2000, Honnens et al 2008. A role for the ovarian steroids in the increase in uterine vascularity in nonpregnant heifers agrees with the absence of the corresponding changes in the pregnant group.…”

Section: Discussionsupporting

confidence: 89%

“…In a previous study in nonpregnant cows (Honnens et al 2008), blood flow was greater in the ipsilateral (relative to the CL) than in the contralateral middle uterine artery on day 10. However, the absence of differences between horns for changes in uterine echotexture, tone and vascularity for both reproductive statuses on days 10-18 in the present study indicates that these intrauterine events were systemically controlled.…”

Section: Discussionmentioning

confidence: 64%

“…The transient increase and decrease in both endometrial and mesometrial vascularity scores between days 10 and 14 occurred in nonpregnant heifers and in both horns of pregnant heifers. Honnens et al (2008) observed an increase in TAMV and a decrease in PI (an indication of vascular resistance) at a similar time in the ipsilateral uterine artery in pregnant cows but not in nonpregnant cows; however, the vascularity within the endometrium was not assessed. The reasons for the transient increase in vascularity are not known, but it occurred when peripheral concentrations of progesterone were high and peripheral concentrations of E 2 were low in both nonpregnant and pregnant heifers.…”

Section: Discussionmentioning

confidence: 82%

“…A decrease in RI represents reduced resistance to blood flow in the vasculature distal to the site of spectral assessment (Ginther 2007). Recently, uterine blood flow in the uterine artery ipsilateral to the CL in nonpregnant and pregnant cows was examined during the first 3 weeks of pregnancy, but the contralateral artery was not examined (Honnens et al 2008). On day 18, the TAMV was greater, oestradiol (E 2 ) concentration was greater and progesterone was lesser in nonpregnant cows than in pregnant cows.…”

Section: Introductionmentioning

confidence: 99%

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Local effect of the conceptus on uterine vascular perfusion during early pregnancy in heifers

Silva¹,

Ginther²

2010

Reproduction

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Colour-Doppler ultrasonography was used to study the spatial relationship between vascular perfusion in the middle of each uterine horn and the reported location of the embryo proper and expanding conceptus using endometrial vascularity scores 1-4 (nil-maximal). Vascularity increased in both uterine horns between days 14 and 18 (day 0Zovulation) in nonpregnant heifers (nZ6) but not in pregnant heifers (nZ11). The increase was temporally associated with decreasing plasma progesterone and increasing oestradiol. In pregnant heifers, a transient increase in endometrial vascularity in the ipsilateral horn (horn with embryo) was not detected before day 18, despite a reported transient increase in blood flow in the ipsilateral uterine artery between days 13 and 17. Endometrial vascularity in the ipsilateral horn first increased (P!0.05) between days 18 and 20. Day 20 is the reported day of adhesiveness between chorion and uterus. An increase (P!0.05) in the contralateral horn between days 18 and 22 was slight, but a greater increase occurred after day 32. Day 32 is the reported day of entry of the allantochorion into the contralateral horn. By day 42, scores were similar between the two horns, and the allantochorion reportedly fills both horns. On days 42-60, at a time when placentomes apparently are limited to the ipsilateral horn, vascularity remained elevated in the ipsilateral horn but decreased in the contralateral horn. Results support the hypothesis that vascular perfusion in each uterine horn during early pregnancy is mediated by direct contact between conceptus and uterus.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Local effect of the conceptus on uterine vascular perfusion during early pregnancy in heifers

Silva¹,

Ginther²

2010

Reproduction

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Bovine Uterus

DesCôteaux¹,

Chastant‐Maillard²,

Gnemmi³

et al. 2009

Practical Atlas of Ruminant and Camelid Reproductive Ultrasonography

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Changes in the uterine metabolome of the cow during the first 7 days after estrus

Tríbulo

Balzano‐Nogueira

Conesa

et al. 2018

Molecular Reproduction Devel

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The uterine microenvironment during the first 7 days after ovulation accommodates and facilitates sperm transit to the oviduct and constitutes the sole source of nutrients required for the development of preimplantation embryos. Knowledge of the composition of uterine fluid is largely incomplete. Using untargeted mass spectrometry, we characterized the uterine metabolome during the first 7 days of the estrous cycle. Bovine uteri were collected on Days 0 ( N = 4), 3 ( N = 4), 5 ( N = 3), and 7 ( N = 4) relative to ovulation and flushed with Dulbecco’s phosphate‐buffered saline. A total of 1,993 molecular features were detected of which 184 peaks with putative identification represent 147 unique metabolites, including amino acids, benzoic acids, lipid molecules, carbohydrates, purines, pyrimidines, vitamins, and other intermediate and secondary metabolites. Results revealed changes in the uterine metabolome as the cow transitions from ovulation to Day 7 of the estrous cycle. The majority of metabolites that changed with day reached maximum intensity on either Day 5 or 7 relative to ovulation. Moreover, several metabolites found in the uterine fluid have signaling capabilities and some have been shown to affect preimplantation embryonic development. In conclusion, the metabolome of the bovine uterus changes during early stages of the estrous cycle and is likely to participate in the regulation of preimplantation embryonic development. Data reported here will serve as the basis for future studies aiming to evaluate maternal regulation of preimplantation embryonic development and optimal conditions for the culture of embryos.

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Uterine blood flow during the first 3 weeks of pregnancy in dairy cows

Cited by 45 publications

References 52 publications

Local effect of the conceptus on uterine vascular perfusion during early pregnancy in heifers

Local effect of the conceptus on uterine vascular perfusion during early pregnancy in heifers

Bovine Uterus

Changes in the uterine metabolome of the cow during the first 7 days after estrus

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