Uterine blood flow and uterine arterial, venous and luminal concentrations of oestrogens on Days 11, 13 and 15 after oestrus in pregnant and non-pregnant sows

Ford, Stephen P.; Christenson, R. K.; Ford, J. J.

doi:10.1530/jrf.0.0640185

Cited by 99 publications

(70 citation statements)

References 13 publications

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“…Oestradiol was the predominant unconjugated oestrogen secreted by blastocysts in the present study (Table 2), in accord with it being the main unconjugated oestrogen in histotroph and in uterine venous plasma (Ford et al 1982) of early pregnant sows. Blastocyst-derived oestrogens could participate in early porcine pregnancy by initiating blastocyst spacing (Pope et al 1982), stimulating endometrial secretion (Geisert et al 1982b), promoting luteal maintenance (Gardner et al 1963;Ford and Magness 1980) or by stimulating uterine blood-flow (Dickson et al 1969;Ford et al 1982).…”

Section: Discussionsupporting

confidence: 84%

“…Blastocyst-derived oestrogens could participate in early porcine pregnancy by initiating blastocyst spacing (Pope et al 1982), stimulating endometrial secretion (Geisert et al 1982b), promoting luteal maintenance (Gardner et al 1963;Ford and Magness 1980) or by stimulating uterine blood-flow (Dickson et al 1969;Ford et al 1982). By regulating calcium flux in endometrial cells, oestrogens of conceptus origin (Fishel 1979) could also activate phospholipase and thereby enhance local PG synthesis (Rubin and Laychock 1978).…”

Section: Discussionmentioning

confidence: 99%

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Production of Steroids and Release of Prostaglandins by Spherical Pig Blastocysts in vitro

Stone¹,

Seamark²,

Kelly³

et al. 1986

Aust. Jnl. Of Bio. Sci.

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Levels of pregnenolone and progesterone in spherical pig blastocysts (near 4 and 15 /lM respectively) exceeded respective levels in histotroph by about 400-fold. When blastocysts were cultured for 5 days in a synthetic medium containing pregnenolone sulfate (l /lM), daily rates of release of pregnenolone, progesterone, androstenedione, testosterone, oestrone and oestradiol were determined to be near 320, 45, 2.6, 27, O' 8 and 9· 2 fmol per blastocyst respectively. Daily outputs of progesterone and testosterone (fmol per blastocyst) diminished (P < O' 05) to l' 3 and undetectable levels « 2) respectively in the presence of Trilostane (94 /lM). Increasing the content of pregnenolone sulfate in the culture medium (to 4·5 /lM) resulted in higher daily rates of release of pregnenolone and progesterone (to near 1740 and 380 fmol per blastocyst respectively), verifying activity of 3i1-hydroxy-Ll 5 -steroid dehydrogenase, and of arylsulfatase, in tissues of intact spherical pig blastocysts. Prostaglandin E2 was the predominant prostaglandin (PG) released by cultured blastocysts (about 1 fmol per blastocyst per hour), hourly rates of release of PGH2 (derived) and PGF2" being near 0·1 and <0·06 fmol per blastocyst respectively.The data establish a capacity for spherical pig blastocysts to release a range of steroids and PGs of possible significance to embryonic growth and development in vivo.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Production of Steroids and Release of Prostaglandins by Spherical Pig Blastocysts in vitro

Stone¹,

Seamark²,

Kelly³

et al. 1986

Aust. Jnl. Of Bio. Sci.

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show abstract

“…The progesterone antiserum was rabbit anti-progesterone-1 la-bovine serum albumin and the androstenedione antiserum was rabbit anti-androstenedione-7a-BSA (Miles Yeda Ltd, Rehovot, Israel). The assay for total oestrogens was modified from that of Ford, Christenson & Ford (1982) in that oestrone and oestradiol were pooled for assay purposes after Sephadex …”

Section: Methodsmentioning

confidence: 99%

Reproductive effects of immunizing heifers against androstenedione and oestradiol-17

Wise¹,

Schanbacher²

1983

Reproduction

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“…The embryonic 'signal' that results in the maintenance of luteal function occurs on about Day 16 after mating in the cow (Northey & French, 1980) and Day 12 after mating in the ewe (Moor & Rowson, 1966) and sow (Ford, Christenson & Ford, 1982a). However, the identity of the molecule(s) that comprises this embryonic signal remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Effects of intrauterine infusion of oestradiol-17 and prostaglandin E-2 on luteal function in non-pregnant heifers

Reynolds¹,

Robertson²,

Ford³

1983

Reproduction

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Summary. Non-pregnant heifers (4/group) received intrauterine infusions of vehicle, oestradiol-17\g=b\(150 ng), addition, the corpora lutea of the heifers treated with oestradiol + PGE-2 were heavier (P < 0\m=.\01) and contained more (P < 0\m=.\05)progesterone than did corpora lutea of the heifers in the other 3 groups on Day 21 (3\m=.\4g and 19\m=.\52\g=m\g/g and 1\m=.\2 g and 1\m=.\65\g=m\g/g, respectively). It is concluded that oestradiol-17\g=b\ and PGE-2, both of which are produced by the bovine conceptus and secreted from the gravid uterus, may act synergistically to maintain luteal function during early pregnancy in the cow.

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Uterine blood flow and uterine arterial, venous and luminal concentrations of oestrogens on Days 11, 13 and 15 after oestrus in pregnant and non-pregnant sows

Cited by 99 publications

References 13 publications

Production of Steroids and Release of Prostaglandins by Spherical Pig Blastocysts in vitro

Production of Steroids and Release of Prostaglandins by Spherical Pig Blastocysts in vitro

Reproductive effects of immunizing heifers against androstenedione and oestradiol-17

Effects of intrauterine infusion of oestradiol-17 and prostaglandin E-2 on luteal function in non-pregnant heifers

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