Uterine artery ligation for treatment of pregnant women with uterine leiomyomas who are undergoing cesarean section

Liu, Wei Min; Wang, Peng Hui; Tang, Wei‐Hua; Wang, I. Te; Tzeng, CR

doi:10.1016/j.fertnstert.2006.01.027

Cited by 54 publications

(29 citation statements)

References 14 publications

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“…The CM has the benefit of two operations in one (CS and myomectomy), thus obviating both the risks and costs of reoperation . In a study from Taiwan, up to 40.9% of patients, who had only CS while also having myoma, required repeat surgery during follow‐up of 6–38 months for symptomatic myoma …”

Section: Advantages Of Myomectomy During Csmentioning

confidence: 99%

Cesarean myomectomy in modern obstetrics: More light and fewer shadows

Sparić

Kadija

Stefanović

et al. 2017

J of Obstet and Gynaecol

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The study aim was to evaluate management of myomas during cesarean section, the pro and cons and the outcomes of cesarean myomectomy. Moreover, we tried to investigate the long-term outcomes of cesarean myomectomy. The authors conducted a literature review using scientific databases, focusing on the benefits and outcomes of cesarean myomectomy and the recent trends regarding this topic, and identified relevant articles, related references and other papers citing them. Despite the demonstrated advantages of cesarean myomectomy, postponed myomectomy after cesarean section was recommended in some instances. Apart from recent reports on the safety and feasibility of cesarean myomectomy, the current literature also describes serious complications of cesarean myomectomy, including even maternal death. This poses a question about the reported rate of complications: whether it is underestimated in common practice. Although some studies strongly suggest the safety of cesarean myomectomy, data on the long-term outcomes of cesarean myomectomy in women are lacking. The risk-benefit ratio of cesarean myomectomy should be re-evaluated in the new century, given the increasing patient age, incidence of myoma in pregnancy, and the wide use of assisted reproductive techniques.

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Section: Advantages Of Myomectomy During Csmentioning

confidence: 99%

Cesarean myomectomy in modern obstetrics: More light and fewer shadows

Sparić

Kadija

Stefanović

et al. 2017

J of Obstet and Gynaecol

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“…Uterine myomas are the most common benign tumors of female reproductive tract, and the prevalence of myomas in pregnancy has been reported to be 2% to 5% [1,2]. The incidence of myomas rises with advancing age.…”

Section: Introductionmentioning

confidence: 99%

The safety of cesarean myomectomy in women with large myomas

et al. 2014

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ObjectiveTo evaluate the safety of cesarean myomectomy in large myomas sized >5 cm.MethodsOne hundred sixty-five pregnant women with myomas who delivered via cesarean section were identified. Ninety-six women had cesarean section without myomectomy, and 65 women underwent cesarean myomectomy. We compared the maternal characteristics, neonatal weight, myoma types, and operative outcomes between two groups. We further analyzed cesarean myomectomy group according to myoma size. The large myoma was defined as myoma >5 cm in size. The maternal characteristics, neonatal weight, and myoma types were compared between two groups. We also compared the operative outcomes such as preoperative and postoperative hemoglobin, operative time, and hospitalized days between two groups.ResultsThere were no significant differences in the maternal characteristics, myoma types, neonatal weight and operative outcomes between cesarean section without myomectomy and cesarean myomectomy. The subgroup analysis according to myoma size (>5 cm or not) in cesarean myomectomy group revealed that there were no significant differences in the mean hemoglobin change (1.2 vs. 1.3 mg/dL, P=0.6), operative time (90.5 vs. 93.1 minutes, P=0.46), and the length of hospital stay (4.7 vs. 5.2 days, P=0.15) between two groups. The comparison of maternal characteristics, neonatal weight, and myoma types between two groups also showed no statistical significance.ConclusionCesarean myomectomy in patients with large myomas is a safe and effective procedure.

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“…In the literature, Science (2005) described the properties of uterine leiomyomas as multifactorial etiologies [1]. Surgery is the main treatment for symptomatic uterine leiomyomas because prevention or medical treatments still fail to deliver satisfactory results [2,3]. The majority of studies on uterine leiomyomas have focused on surgical techniques and clinical outcomes while conventional biochemical studies have attempted to find the molecules that stimulate myoma growth.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of the Integrin α<sub><i>v</i></sub> Signaling Pathway in Uterine Leiomyomas

Tsai

Liu

Pai³

et al. 2010

Gynecol Obstet Invest

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Objective: To investigate alterations of integrin α_v, survival and apoptosis signaling pathways in uterine leiomyomas. Materials and Methods: In a prospective study of 50 women with uterine leiomyomas that had been pathologically confirmed, specimens were obtained laparoscopically from 2007 to 2009. The expressions of integrin α_v signaling pathways (Ras/Raf/ERK1/2, Akt and cleaved caspase-3), surface microstructures by surface electron microscopy and immunohistochemical findings were assessed. Results: The study yielded novel results: (1) the integrin α_v expression approached a low level (mRNA 0.39 ± 0.06, protein 0.47 ± 0.08) with coherent alterations of its downstream signaling molecules (Ras, p-c-Raf, p-ERK1/2) (p < 0.001); (2) smoother surface microstructures of uterine leiomyomas were correlated with low integrin α_v expressions, and (3) survival signaling and apoptosis signaling were significantly down- and upregulated respectively (p < 0.001). Conclusion: Integrin α_v and related survival signaling pathways were downregulated, but the apoptosis was upregulated in uterine leiomyomas. Benign smooth-contoured tumors may have low integrin expressions and cancer invasion potentials.

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Uterine artery ligation for treatment of pregnant women with uterine leiomyomas who are undergoing cesarean section

Cited by 54 publications

References 14 publications

Cesarean myomectomy in modern obstetrics: More light and fewer shadows

Cesarean myomectomy in modern obstetrics: More light and fewer shadows

The safety of cesarean myomectomy in women with large myomas

Downregulation of the Integrin α<sub><i>v</i></sub> Signaling Pathway in Uterine Leiomyomas

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