Uterine and systemic hemodynamic interrelationships and their response to hypoxia

Dilts, P.V.; Brinkman, C.R.; Kirschbaum, Thomas H.; Assali, N.S.

doi:10.1016/s0002-9378(16)34357-5

Cited by 80 publications

(20 citation statements)

References 26 publications

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“…We were unable to confirm the finding of decreased umbilical vein pressure in this or other series [10]. In fact, umbilical vein pressure almost always increases during hypoxia.…”

Section: Discussioncontrasting

confidence: 86%

“…The intra-abdominal portion of the common umbilical vein was isolated, prior to its entrance into the liver, through a small supra-umbilical incision, and was fitted with a cuffed type balanced field electromagnetic flow transducer. Technical details of these procedures as well as the calibration characteristics of this flowmeter have been previously described [3,10,15].…”

Section: Methodsmentioning

confidence: 99%

“…Continuous recording were made during all these periods of maternal arterial, fetal arterial, umbilical vein and inferior vena cava pressures as well as of umbilical blood flow; recordings were made on an Oflfner dynograph and Ampex magnetic tape. Blood gases and pH were analyzed on Beckman and Radiometer equipment by techniques previously described [3,10].…”

Section: Methodsmentioning

confidence: 99%

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The Role of the Umbilical Sinus in the Regulation of Placental Vascular Resistance

Brinkman¹,

Kirschbaum²,

Assali³

1970

Gynecol Obstet Invest

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The role of the umbilical sinus – ductus venosus complex in the regulation of umbilical venous and placental vascular resistance was investigated in 12 near term exteriorized fetal lambs before and after the induction of mild and severe hypoxia. Mild maternal hypoxia caused increases in the umbilical vein and inferior vena cava pressures and a decrease in the umbilical blood flow rate. Severe maternal hypoxia caused an increase in the inferior vena cava pressure and a decrease in the umbilical blood flow, both of which were statistically significant. During mild maternal hypoxia the placental vascular resistance increased 11 % and the umbilical sinus vascular resistance increased 24%, while during severe hypoxia the increases were 17 and 66% respectively, thus demonstrating a greater sensitivity of the umbilical sinus vasculature to the stress of hypoxia and emphasizing its role in placental vascular resistance.

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“…We were unable to confirm the finding of decreased umbilical vein pressure in this or other series [10]. In fact, umbilical vein pressure almost always increases during hypoxia.…”

Section: Discussioncontrasting

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The Role of the Umbilical Sinus in the Regulation of Placental Vascular Resistance

Brinkman¹,

Kirschbaum²,

Assali³

1970

Gynecol Obstet Invest

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“…For example, in the sheep, uterine blood flow represents approximately 2% of the cardiac output before pregnancy and 2()%' at term (Dilts et al, 1969). As first described in the rabbit (Barcroft and Ratschild, 1932), the expansion of uterine circulation precedes by a considerable margin of time the period of rapid fetal growth that occurs during the last third of gestation (Fig.…”

Section: Uterine Vascularization and Circulationmentioning

confidence: 86%

Nutrition and Pregnancy

Rosso

Cramoy

1979

Nutrition

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“…The consumption or production of lactate by the total uterine mass or fetus could be approximated by applying the observations on uterine and umbilical blood flow during hypoxia reported by DILTS et al [4]. They noted an average fall in uterine blood flow of 30% during prolonged acute hypoxia (ewe respiring 6% O 2 ), and a fall in umbilical blood flow of 50%.…”

Section: Discussionmentioning

confidence: 99%

Effects in Sheep of Hypoxia on Levels of Lactate, Pyruvate, and Glucose in Blood of Mothers and Fetus

Mann

1970

Pediatr Res

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ExtractIn nine experiments with sheep, effects of hypoxia on levels of lactate, pyruvate, and glucose in maternal and fetal blood were studied. Blood samples were obtained simultaneously from the four uterine and umbilical vessels prior to, during, and following an episode of severe hypoxia.The concentration of lactate, pyruvate, and hydrogen ions, and the CO 2 tension was greater in the umbilical circulation than in the uterine circulation during the period prior to hypoxia. There was no apparent exchange of lactate or pyruvate across the placenta in either direction at this time. The concentration of glucose in the umbilical vein, however, was directly related to that of the uterine vein.When progressively mild-to-severe hypoxia occurred in the fetus and placenta, first pyruvate, then lactate, accumulated within the umbilical circulation. The venous-arterial (V-A) difference of lactate in the uterine and umbilical vessels, as well as total uterine and fetal excess lactate production, increased significantly during the final 10% interval of the period of hypoxia. The concentration of lactate in the uterine vein blood was directly related to the concentration of lactate in the umbilical vein during this final period. The decrease in the concentration of glucose in the uterine vein blood was greater than the decrease in the umbilical vein blood.The metabolism of lactate proceeded slowly after relief from hypoxia. Though the concentration of lactate was still elevated approximately 30 min into recovery, the V-A and maternal-fetal concentration differences were similar to prehypoxic values. Speculation

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Uterine and systemic hemodynamic interrelationships and their response to hypoxia

Cited by 80 publications

References 26 publications

The Role of the Umbilical Sinus in the Regulation of Placental Vascular Resistance

The Role of the Umbilical Sinus in the Regulation of Placental Vascular Resistance

Nutrition and Pregnancy

Effects in Sheep of Hypoxia on Levels of Lactate, Pyruvate, and Glucose in Blood of Mothers and Fetus

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