Uterine Adenosarcoma

Abstract

Müllerian adenosarcoma is an uncommon biphasic tumor composed of malignant stromal and benign epithelial components. Morphologically, adenosarcoma is characterized by a broad leaflike architecture, reminiscent of phyllodes tumors of the breast. Periglandular cuffing of the stromal cells around the compressed or cystically dilated glands is characteristic. The mesenchymal component is typically a low-grade spindle cell sarcoma, whereas the epithelial counterpart is commonly endometrioid with frequent squamous or mucinous metaplasia and may, in some circumstances, show mild to moderate atypia. In all cases, it is important to assess for the presence of sarcomatous overgrowth and myometrial invasion, which are the prognostic factors. In this brief review, we present the clinical, histopathologic, and immunohistochemical features of adenosarcoma, as well as updates on the molecular biology of this neoplasm.

Uterine Adenosarcoma

“…While there is agreement that complete surgical resection is the treatment of choice, the right adjuvant chemotherapeutic regimen has yet to be defined. Cases with sarcomatous overgrowth and recurrences of the disease still present a challenge for the clinician [31]. …”

A Rare Case of Intramural Müllerian Adenosarcoma Arising from Adenomyosis of the Uterus

“…Despite their rarity, these tumors affect women of all age groups [1]. Although most adenosarcomas of the female genital tract occur in post-menopausal women (median age, 58 years), these tumors have been reported in perimenopausal women as well as in children as young as 10 years old [12].…”

“…Müllerian adenosarcoma is a relatively uncommon variant of Müllerian mixed tumor with distinctive clinical and histologic characteristics [1]. The term Müllerian adenosarcoma was first used in 1974 to describe an unusual variant of Müllerian mixed tumor of the uterus, characterized by a mixture of benign or occasionally mildly atypical glandular components and malignant, usually low-grade, stromal components [2].…”

“…The term Müllerian adenosarcoma was first used in 1974 to describe an unusual variant of Müllerian mixed tumor of the uterus, characterized by a mixture of benign or occasionally mildly atypical glandular components and malignant, usually low-grade, stromal components [2]. The morphologic features of these neoplasms distinguish them from other biphasic (epithelial and mesenchymal) tumors, both benign and malignant [1]. Müllerian adenosarcoma is generally of low malignant potential, except when accompanied by sarcomatous overgrowth and myoinvasion [1].…”

“…The morphologic features of these neoplasms distinguish them from other biphasic (epithelial and mesenchymal) tumors, both benign and malignant [1]. Müllerian adenosarcoma is generally of low malignant potential, except when accompanied by sarcomatous overgrowth and myoinvasion [1]. Patients with Müllerian adenosarcoma lacking these two histopathologic features have an excellent prognosis [1]; these tumors may recur locally but only rarely metastasize [2].…”