Usutu virus: An emerging flavivirus with potential threat to public health in Africa: Nigeria as a case study

Akinsulie, Olalekan Chris; Adesola, Ridwan Olamilekan; Bakre, Adetolase; Adebowale, Oluwawemimo; Adeleke, Richard; Ogunleye, Seto Charles; Oladapo, Ifeoluwa Peace

doi:10.3389/fvets.2023.1115501

Cited by 13 publications

(7 citation statements)

References 72 publications

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“…The NS5 is the most conserved protein encoded by flaviviruses. In JMTV, the NS5-like protein encoded by segment 1 has been widely used for genetic and evolutionary analysis ( 39 ). By comparing the mutation sites of the NS5-like protein among JMTV strains, the distinguishing mutations were observed between the two genotypes in the NSP1 coding region.…”

Section: Discussionmentioning

confidence: 99%

Identification and phylogenetic analysis of Jingmen tick virus in Jiangxi Province, China

Liu,

Hu,

Cao

et al. 2024

Front. Vet. Sci.

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Jingmen tick virus (JMTV) is a newly identified segmented flavivirus that has been recognized in multiple hosts, such as humans, buffalos, bats, rodents, mosquitos and ticks. Various clinical cases and studies manifested that JMTV is a true arbovirus with wide host spectrum and showed potential threats toward public health. JMTV has been reported in multiple countries in Asia, Europe, Africa, and America. Moreover, wild boars serve as an important intermediary between humans and the wild ecological system. In China, it has been reported in nine provinces, while the prevalence and the distribution of JMTV in most regions including Jiangxi Province are still unknown. Thus, to profile the distribution of JMTV in Jiangxi Province, an epidemiological investigation was carried out from 2020 to 2022. In current study, 66 ticks were collected from 17 wild boars in Jiangxi Province. The results showed that 12 out of 66 ticks were JMTV positive, indicating JMTV is prevalent in ticks and boars in Jiangxi Province. The genome sequences of JMTV strain WY01 were sequenced to profile viral evolution of JMTV in China. Phylogenetic analysis divided JMTV strains into two genotypes, Group I and Group II. WY01 belongs to Group II and it shares the closest evolutionary relationship with the Japan strains rather than the strains from neighboring provinces in China suggesting that JMTV might have complex transmission routes. Overall, current study, for the first time, reported that JMTV is prevalent in Jiangxi Province and provided additional information concerning JMTV distribution and evolution in China.

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Section: Discussionmentioning

confidence: 99%

Identification and phylogenetic analysis of Jingmen tick virus in Jiangxi Province, China

Liu,

Hu,

Cao

et al. 2024

Front. Vet. Sci.

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“…Based on the available data and gaps between 1978 and 2017, the absence of reported cases might have been due to lack of testing, cases not being presented to the hospitals, lack of surveillance programs (53), incomplete reporting practices, and insufficient scientific research into mpox virus etc. This is evident in the number of cases reported between 2017 and 2022 (Figure 3) marked at approximately 558 suspected cases, 241 confirmed and 8 deaths spanning through all age groups as reported by the Nigeria CDC (54,55). The current 2022 monkeypox virus outbreak has spanned through all the regions in Nigeria, presenting a more complicated conditions and needs for intensive efforts toward mitigating the spread of the virus as against the previous outbreaks.…”

Section: Situation In Nigeria and The Global Communitymentioning

confidence: 99%

The re-emergence and transmission of Monkeypox virus in Nigeria: the role of one health

Ogunleye,

Akinsulie,

Aborode

et al. 2024

Front. Public Health

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The Monkeypox virus, commonly abbreviated as mpox, is a viral zoonosis that is experiencing a resurgence in prevalence. It is endemic to regions of West and Central Africa that are characterized by dense forested areas. Various measures pertaining to animals, humans, and the environment have been recognized as potential factors and catalysts for the spread of the disease throughout the impacted regions of Africa. This study examines the various factors contributing to the transmission of the virus in Nigeria, with a particular focus on the animal-human and inter-human modes of transmission in rural communities and healthcare facilities. The One Health approach was emphasized as crucial in the prevention and management of this issue. Literature suggests that preventing repeated zoonotic introductions could potentially halt the transmission of the mpox virus from animal to human hosts, leading to a potential decrease in human infections.

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“…albopictus mosquitoes, in particular, pick up the virus when they feed on infected people and pass it on to other people when they feed on their blood [27]. There are also other arboviruses in the region that have been largely under-investigated, which have the potential of causing an outbreak in either human or animal populations, like Usutu virus [28].…”

Section: Transmission Dynamics Of Major Viral Encephalitides In West ...mentioning

confidence: 99%

Epidemiology and Transmission Dynamics of Viral Encephalitides in West Africa

Akinsulie,

Adesola,

Aliyu

et al. 2023

Infectious Disease Reports

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Encephalitis is an inflammation of the brain, often caused by an autoimmune reaction, or in most cases because of a direct viral, bacterial, or parasitic infection. Viral encephalitides (VE) presents a significant public health concern globally, especially in West Africa. There are more than five hundred known arthropod-borne viruses (arboviruses), with over a hundred of them identified to cause encephalitic diseases in humans and animals, giving rise to a tremendous burden of the diseases and socioeconomic strains in tropical and subtropical regions worldwide. Despite their importance, few effective preventive and control measures in the form of vaccines and therapies are available, and when they are, their use is limited. These limitations are largely hinged on the paucity of information about the molecular epidemiology and transmission patterns of VE in West Africa. Here, we reviewed the transmission dynamics, molecular epidemiology, and the ecological drivers of VE in West Africa. Collectively, timely and accurate interventions are essential for encephalitic viral disease control. Moreover, the integrated health system approach, combining surveillance, vaccination, vector control, and community engagement, could be effective in preventing viral encephalitis globally.

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Usutu virus: An emerging flavivirus with potential threat to public health in Africa: Nigeria as a case study

Cited by 13 publications

References 72 publications

Identification and phylogenetic analysis of Jingmen tick virus in Jiangxi Province, China

Identification and phylogenetic analysis of Jingmen tick virus in Jiangxi Province, China

The re-emergence and transmission of Monkeypox virus in Nigeria: the role of one health

Epidemiology and Transmission Dynamics of Viral Encephalitides in West Africa

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