Background: A series of reforms were implemented to improve the quality of primary care services in China. This study aims to assess patients' perceived quality of primary health care between rural and urban community health centers in Guangdong.Methods: A cross-sectional survey was conducted from July to December 2015 in Guangdong. We surveyed 1010 respondents who visited either CHCs/CHSs in urban areas or THCs/RHSs in rural areas via face-to-face interviews. A validated Chinese version of Primary Care Assessment Tool-Adult Short Version (PCAT-AS), representing 10 primary care domains, was used to collect information on patients’ primary care experiences. T-test was used for comparison on domain scores and total scores between patients from CHCs/CHSs and THCs/RHSs. Analysis of covariance was employed to compare the adjusted PCAT domain scores and total scores. Multilevel models were used to explore factors associated with PCAT total scores. Results: Overall, patients reported a lower level of experience of community orientation and family centeredness compared to other primary care domains. Patients from THCs/RHSs settings in the rural area reported better primary care experience in four domains, including first contact, accessibility, ongoing care, and community orientation. Higher education background, and those with a chronic disease were associated with better primary care experience, after controlling for confounding factors. Patients who preferred primary care institutions when getting sick or used health services more frequently reported better primary care experience.Conclusion: Continued efforts are needed to strengthen primary care performance, particularly in community orientation and family centeredness. Primary care delivery in CHCs/CHSs settings should be improved in four domains including first contact, accessibility, ongoing care, and community orientation.