Uso De Óleos Essenciais No Controle Dos Sinais Clínicos Das Diarreias Neonatais Em Leitões Nascidos De Fêmeas Com Diferentes Ordens De Parto

Rossi, Carlos Augusto Rigon; Soares, Marcelo; Luchese, Franciele Camila; Santúrio, Jânio Morais

doi:10.1590/1089-6891v16i119669

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…Several studies show that bioactive compounds reduce the diarrhea rate in suckling and nursery piglets such as red pepper oil [25], garlic, pepper and saffron oleoresins [26], oregano oil and rosemary [4] can modulate the gut microbiota through selectivity [5,19]. However, the flavonoids present in the citrus extracts have a low pKa, not acting in pH acidification, but are terpenoids that act directly on the lipid membranes of gram-positive bacteria [15], and can act selectively on the gut microflora.…”

Section: Resultsmentioning

confidence: 99%

“…However, the flavonoids present in the citrus extracts have a low pKa, not acting in pH acidification, but are terpenoids that act directly on the lipid membranes of gram-positive bacteria [15], and can act selectively on the gut microflora. Parity order may also interfere in piglet's immunity, differing especially between primiparous and multiparous sows [4]. In this study, only sows with a higher parity order than OP3 were used, therefore, the effect of immune efficiency on the litters can be ignored.…”

Section: Resultsmentioning

confidence: 99%

“…However, the withdrawal of antibiotics in the suckling phase has a negative effect on piglets, so alternatives has been adopted to replace antibiotics. Studies have shown that plant extracts promote antimicrobial and antioxidant actions, improve the intestinal functions of suckling piglets [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Oral Administration of Citrus Extracts in Suckling Piglets

Pereira

Hilgemberg

Primieri

et al. 2019

Braz. arch. biol. technol.

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An experiment was conducted to evaluate the performance of suckling piglets subjected to oral administration of citrus extracts (CE). Twenty sows were used with ten sucking piglets on average initial weight of 1.26 kg (± 0.32) for 21 days. The experimental design was a randomized complete block design with two treatments: Negative Control (without antimicrobials) and Citrus Extracts (ascorbic acid + flavonoids, oral administration of 0.3 mg kg of BW via pigdoser) with ten repetitions each. The number of live-born piglets in females PO5 was 21% higher than in PO3 sows. Sows where piglets received CE showed a 10% higher (P <0.05) feed intake in the last week of lactation. From 8 to 21 days, the feed conversion of NC sows was 23 and 38% lower (P <0.05) than sows where piglets HIGHLIGHTS• Restrictions on the use of antibiotics promote the search for alternatives to its use.• The use of citrus extracts for piglets was studied• The addition of citrus extract did not improve the performance of sows and piglets.• Citrus extract alters intestinal morphology and reduces diarrhea in piglets Pereira, L.P.; et al.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Oral Administration of Citrus Extracts in Suckling Piglets

Pereira

Hilgemberg

Primieri

et al. 2019

Braz. arch. biol. technol.

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“…Alguns trabalhos na literatura demonstraram atividades farmacológicas de OE, utilizando testes in vitro contra parasitos de interesse veterinário. Foi comprovada a ação de OE como antibacteriano (MULLEN et al, 2014;ROSSI et al, 2015), antifúngico (CLEFF et al, 2012;MUGNAINI et al, 2012), coccidicida (JITVIRIYANON et al, 2016), carrapaticida (CHAGAS et al, 2016;PEIXOTO et al, 2015) e como anti-helmíntico (FERREIRA et al, 2016;MACEDO et al, 2011;RIBEIRO et al, 2015). A ação de OE em helmintos vem sendo atribuída aos seus compostos majoritários, podendo ocorrer ainda, por uma relação sinérgica ou aditiva entre seus componentes (BORTOLUZZI et al, 2021;KATIKI et al, 2017).…”

Section: óLeos Essenciais (Oe)unclassified

Fitoterapia No Controle De Parasitos Gastrintestinais De Ruminantes: Ênfase No Gênero Mentha E Seus Componentes Bioativos

Bortoluzzi

Buzatti²,

Deschamps

et al. 2020

Ars Vet

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Essa revisão apresenta considerações acerca da relevância das infecções de parasitos gastrintestinais (PGI) em ruminantes, abordando a importância de fármacos antiparasitários no controle das helmintoses e demais alternativas. Foi realizada uma abordagem conceitual e histórica sobre o controle de PGI e o processo de desenvolvimento da resistência parasitária. Como alternativa da baixa eficácia de medicamentos, foi feita uma descrição detalhada sobre o uso de óleos essenciais (OE) e de componentes bioativos no controle das PGI em ruminantes. A produção de OE de plantas, passa pela composição química, técnicas de extração dos componentes, mecanismo de ação e ensaios para validação da sua atividade terapêutica, incluindo sua ação anti-helmíntica. Este artigo traz, na sua segunda parte, uma descrição detalhada de duas espécies do gênero Mentha, com foco em sua biologia, composição química e mecanismos de ação de seus OE. Dentro desse tópico, as espécies Mentha vilosa e M. piperita são as mais estudadas, bem como os seus componentes majoritários e bioativos; carvone e limoneno. Ao final do documento, discutimos sobre a técnica de cromatografia gasosa e espectrometria de massas, que se faz obrigatória para a identificação de compostos presentes em OE. Incluímos ainda, o detalhamento sobre tecnologias de nanoemulsão e suas vantagens na confecção de formulações mais estáveis, menos tóxicas aos hospedeiros e com potencial de aumentar a eficácia de fármacos contra as PGI, para o desenvolvimento de novos compostos fitoterápicos ecosustentáveis.

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“…Os OE apresentam diversas atividades farmacológicas de interesse na medicina veterinária, como ação antibacteriana [67,86], antifúngica [15,66], coccidicida [41,79], carrapaticida [12,74] e anti-helmíntica [23,54,82].…”

Section: óLeos Essenciaisunclassified

Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

André

Ribeiro

Oliveira

et al. 2018

Acta Scientiae. Vet.

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Background: Gastrointestinal nematodes are one of the major health and economic problem of sheep and goats in the world. The control of these nematodes is carried out conventionally with synthetic anthelminths, which favored the selection of gastrointestinal nematode (GIN) populations multiresistant to anthelmintics. The emergence of anthelmintic resistance has stimulated the search for new alternatives to control small ruminant GIN, standing out the use of plants and their bioactives compounds, such as essential oils (EO). The objective of this review was to present the main characteristics and anthelmintic activity of EO, their isolated compounds and drug delivery systems in the control of GIN.Review: Essential oils are a complex blend of bioactive compounds with volatile, lipophilic, usually odoriferous and liquid substances. EO are composed of terpenes, terpenoids, aromatic and aliphatic constituents. EO has various pharmacological activities of interest in preventive veterinary medicine such as antibacterials, antifungals, anticoccicids, insecticides and anthelmintics. In vitro and in vivo tests are used to validate the anthelmintic activity of EO on GIN. In vitro tests are low cost screening tests that allow the evaluation of the anthelmintic activity of a large amount of bioactive compounds on eggs, first (L1) and third stage larvae (L3), and adult nematodes. The antiparasitic effect of EO is related to its main compound or to the interaction of the compounds. These bioactive compounds penetrate the cuticle of the nematodes by transcuticular diffusion, altering the mechanisms of locomotion, besides causing cuticular lesions. Following in vitro evaluation, the acute and sub-chronic toxicity test should be performed to assess the toxicity of the bioactive compounds and to define the dose to be used in in vivo tests. In vivo tests are more reliable because the anthelmintic effectiveness of bioactive compounds is evaluated after the metabolization process. The metabolization process of the bioactive compounds can generate metabolites that exhibit or not anthelmintic effectiveness. The in vivo tests assessing the anthelmintic effectiveness of bioactive compounds in sheep and goats are the fecal egg count reduction test and the controlled test. OE promoted reduction of egg elimination in faeces which may be related to cuticular and reproductive alterations in GIN, and reduction of parasite burden in in vivo tests. Due to the promising results obtained with OE in the in vivo tests, interest has been aroused in using nanotechnology as an alternative to increase the bioavailability of OE and consequently, potentializing its anthelmintic effect, reducing the dose and toxicity of the biocompounds. In addition to nanotechnology, the isolation and chemical modification of compounds isolated from OE have been employed to obtain new molecules with anthelmintic action and understand the mechanism of action of EO on the small ruminant GIN.Conclusion: The use of EO and their compound bioactive in the control of resistant populations of GIN is a promising alternative. The adoption of strategies in which natural products can replace synthetic anthelmintics, such as in dry periods and use synthetic anthelmintics in the rainy season when the population in refugia in the pasture is high, thus reducing the dissemination of GIN resistant populations. As perspective, the evaluation of pharmacokinetics and pharmacodynamics of these natural products should be performed so that one defines treatment protocols that optimize the anthelmintic effect.

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Uso De Óleos Essenciais No Controle Dos Sinais Clínicos Das Diarreias Neonatais Em Leitões Nascidos De Fêmeas Com Diferentes Ordens De Parto

Cited by 7 publications

References 14 publications

Oral Administration of Citrus Extracts in Suckling Piglets

Oral Administration of Citrus Extracts in Suckling Piglets

Fitoterapia No Controle De Parasitos Gastrintestinais De Ruminantes: Ênfase No Gênero Mentha E Seus Componentes Bioativos

Essential Oils and Their Bioactive Compounds in the Control of Gastrointestinal Nematodes of Small Ruminants

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