Uso de analgésicos e o risco da automedicação em amostra de população urbana: estudo transversal

Barros, Guilherme Antônio Moreira de; Calônego, Marco Antônio Marchetti; Mendes, Rannier F.; Castro, Raphael A.M.; Faria, João F.G.; Trivellato, Stella A.; Cavalcante, Rodney Segura; Fukushima, Fernanda Bono; Dias, Adriano

doi:10.1016/j.bjan.2019.09.005

Cited by 17 publications

(5 citation statements)

References 33 publications

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“…Barros et al 2 416 participants from an urban Brazilian population. 190 had chronic pain, with the majority being women.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, the increase in life expectancy and better treatments that permit survival in previously lethal diseases in-crease the demand for analgesia, alerting to the possibility of reverberation of the phenomenon in Brazil. In this context, data shows that there was an expressive increase in the average of Brazilian patients with chronic pain significantly higher than the world average, affecting 41% of the population 2 . It is known, however, that the use of opioid analgesics in the Brazilian reality predominates basically in the fields of acute pain and chronic oncologic pain, with no data for chronic non-oncologic pain 2 .…”

Section: Introductionmentioning

confidence: 96%

“…In this context, data shows that there was an expressive increase in the average of Brazilian patients with chronic pain significantly higher than the world average, affecting 41% of the population 2 . It is known, however, that the use of opioid analgesics in the Brazilian reality predominates basically in the fields of acute pain and chronic oncologic pain, with no data for chronic non-oncologic pain 2 . In the medical literature, little updated information and data overall is available on the use of opioids in the Brazilian scenario and possible developments, such as dependence and deviation of function.…”

Section: Introductionmentioning

confidence: 96%

“…Statistical data from the United States shows that in the last 20 years the number of deaths from opioid overdose has tripled due to increased prescription and an imbalance in the regulation and access to these drugs by the population 1 . Particularly in developed countries, over-prescription of opioids results in misuse, and is highly related to abuse, addiction, and recreational use of these drugs 2 . In addition, the increase in life expectancy and better treatments that permit survival in previously lethal diseases in-crease the demand for analgesia, alerting to the possibility of reverberation of the phenomenon in Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Opioid consumption and prescription in Brazil: integrative review

Piovezan,

Sousa,

e-Silva

et al. 2022

BRJP

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BACKGROUND AND OBJECTIVES:In the past twenty years, the number of deaths caused by opioid overdose has tripled in the United States. There is, in literature, a scarcity of up-to-date evidence regarding opioids consumption in the Brazilian scenario. The objectives of this study was to know, through a literary review, the pattern of opioid analgesics consumption in Brazil. METHODS: An integrative review of the literature, performed in the PubMed, BVS and Scielo databases from August 30 to October 22, 2020. The search strategy included the following terms, "Opioid-related disorders" or "Opioid epidemic" or "Opioid analgesics" and "Brazil". Inclusion criteria: published in the last five years; studies on humans. Exclusion criteria: studies not related to the objective of this review; letters, editorials, commentaries and secondary studies. RESULTS:The results showed patients' dissatisfaction with pain management when compared to patients from developed countries, the lack of knowledge and adequate public policies on the use of opioids among health professionals make them view opioids as the last treatment alternative. The practice of analgesic self-medication is frequent in patients with chronic diseases, which may be the cause of the low prescription of opioid analgesics by health professionals.

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“…Barros et al 2 416 participants from an urban Brazilian population. 190 had chronic pain, with the majority being women.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Opioid consumption and prescription in Brazil: integrative review

Piovezan,

Sousa,

e-Silva

et al. 2022

BRJP

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“…Ainda há poucos dados na literatura brasileira que demonstrem o perfil de analgésicos consumidos pelo país, porém alguns estudos ilustram o excesso no uso desta classe terapêutica e de anti-inflamatórios não esteroidais (AINES). Dipirona, paracetamol e AINES estão entre os fármacos mais utilizados [2][3][4][5].…”

Section: Swiss Mice Modelunclassified

Efeitos sobre funções cognitivas, analgésicos e ansiolíticos de medicamentos homeopáticos e da 7-epiclusianona em um modelo experimental de camundongos Swiss

Dos Reis,

G. R. Ribeiro,

I. França

et al. 2023

Rev. Colomb. Cienc. Quím. Farm.

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Contextualização: o consumo exacerbado de analgésicos e ansiolíticos vêm setornando uma grande preocupação mundial e, no Brasil, isso não é diferente, constituindoum sério problema de saúde pública. Objetivos: este estudo testou doiscomplexos homeopáticos e um produto natural paras as atividades analgésica,ansiolítica, e sobre as funções cognitiva. Metodologia: foram utilizados 40 camundongosSwiss, recebendo dieta padrão e água ad libitum, igualmente divididos em 5grupos: i. Grupo do Complexo Homeopático (H1), cuja constituição e potênciassão, Ignathia amara L. 6CH, Phosphorus 6CH, Aconitum napelus L. 6CH, Valerianaofficinalis L. 6CH e Gelsemium sempervirens L. 6 CH; ii. Grupo do ComplexoHomeopático (H2), cuja constituição e potências são, Arnica montana L. 6CH, Rhus toxicodendum L. 6CH, Atropa belladonna L. 6CH, Aconitum napelus L.6CH, Symphytum officinale L. 6CH e Hypericum perforatum 6CH; iii. Grupo da7-epiclusianona (7-EPI) (150mg/kg, 60 min antes); iv. Grupo da Indometacina (GI,10mg/kg, 60 min antes); e v. Grupo Controle (GC, placebo -salina). Os tratamentoscom os complexos homeopáticos foram feitos por 14 dias. Os seguintes testes foramperformados: Teste de Hot Plate (efeito analgésico); Teste de Campo Aberto (efeitoansiolítico); Teste de Reconhecimento de Objetos (TRO) Novo (capacidade cognitiva),sendo todos filmados, e analisados estatisticamente. Resultados: houve umsignificativo efeito em grooming entre os grupos H1, H2 e 7-EPI, comparados aoGC (p < 0,05), demonstrando seus efeitos ansiolíticos, e um significativo efeito notempo de latência entre os grupos H2, 7-EPI e GI (p < 0,05), comparados ao GC,demonstrando analgesia. As substâncias testadas não demonstraram ter significativoefeito no teste de exploraçãodo objeto novo, portanto não interferindo na capacidadecognitiva dos camundongos. Conclusão: houve consideráveis efeitos analgésico(H1, H2 e 7-EPI) e ansiolítico (H2 e 7-EPI), sendo que tais compostos positivamentenão interferiram na função cognitiva dos camundongos.

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Neuromodulation of Acid‐Sensitive Ion Channels (ASICs) and Anti‐Inflammatory Potential by Lichenxanthone in Adult Zebrafish (Danio rerio): Experimental and Docking Studies

Ribeiro Liberato,

Bezerra Maciel,

Wlisses Da Silva

et al. 2024

Chemistry & Biodiversity

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The xanthone Lichenxanthone did not show toxic effects (LC50 > 1.0 mg/mL). Lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid‐sensitive ion channels (ASICs). In the analysis of anti‐inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of Lichenxanthone reduced the edema induced by k‐carrageenan 3.5%, observed from the fourth hour of analysis. This effect was similar to that observed with ibuprofen (positive control). No leukocyte infiltrates were observed in Lichenxanthone, suggesting that the compound acts in the acute inflammatory response. The results of the molecular docking study revealed that Lichenxanthone exhibited better affinity energy when compared to the ibuprofen control against the two targets evaluated.

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Uso de analgésicos e o risco da automedicação em amostra de população urbana: estudo transversal

Cited by 17 publications

References 33 publications

Opioid consumption and prescription in Brazil: integrative review

Opioid consumption and prescription in Brazil: integrative review

Efeitos sobre funções cognitivas, analgésicos e ansiolíticos de medicamentos homeopáticos e da 7-epiclusianona em um modelo experimental de camundongos Swiss

Neuromodulation of Acid‐Sensitive Ion Channels (ASICs) and Anti‐Inflammatory Potential by Lichenxanthone in Adult Zebrafish (Danio rerio): Experimental and Docking Studies

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