Uso crônico e regular de estatina previne fibrilação atrial no pós-operatório de cirurgia cardíaca

Alves, Renato Jorge; Campos, Rodrigo Noronha; Nakiri, Kenji

doi:10.1590/s0066-782x2010005000129

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…Postoperative AF differ not only in its development among cases with myocardial revascularization, but also it has an incidence of 11-40%. This ratio is evaluated as a complication, which reaches up to 50% among patients with valvular surgery [ 1 , 2 ]. Moreover, it is the most common complication, which is encountered during the intensive care unit stay.…”

Section: Introductionmentioning

confidence: 99%

Serum cholesterol levels and postoperative atrial fibrillation

Aydın

Susam

Kiliçaslan

et al. 2014

J Cardiothorac Surg

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BackgroundPost-operative atrial fibrillation is an important complication after coronary bypass surgery. As inflammation and oxidative stress were makedly encountered in the etiology, high cholesterol was also defined to provoke atrial fibrillation. In this present study, the relationship between postoperative atrial fibrillation and preoperative serum lipid levels were evaluated.MethodsA total of 100 patients, who were operated at the department of Cardiovascular Surgery of our hospital were included to the study analysis. Patients, who had preoperative atrial fibrillation, thyroid dysfunction, or left atrial dilatation (above 4.5 cm) were excluded from the study. Patients were divided into two groups with postoperative atrial fibrillation development (Group I n = 36), and without atrial fibrillation development (Group II n = 64). Preoperative routine blood analyses, ECG, echocardiography were evaluated. Patients were followed for atrial fibrillation development for one month starting from the intensive care unit at the postoperative period. Serum lipid profiles and thyroid function were measured. For homogenization of inflammatory factors and oxidative stress, treatments other than statins, betablockers, calcium channel blockers, aspirin, ACE inhibitors, and ARB were stopped for 10 days. Atrial fibrillation for at least ≥5 minutes in the intensive care unit was accepted as postoperative atrial fibrillation.ResultsDemographic data were similiar between groups (p > 0.05). There was no difference in TC levels between groups, whereas LDL-C levels were statistically lower in patients developing post-operative atrial fibrillation (106.67 ± 28.36 vs 118.75 ± 27.75; P < 0.05).ConclusionThe more lowered is the LDL-C in the preoperative period, the more reduced risk of postoperative atrial fibrillation development. High levels of LDL-C in the preoperative period could be predictor of atrial fibrillation development in the post operative period.

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Section: Introductionmentioning

confidence: 99%

Serum cholesterol levels and postoperative atrial fibrillation

Aydın

Susam

Kiliçaslan

et al. 2014

J Cardiothorac Surg

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“…Under a general category of sundry themes, Alves et al45 evaluated whether the chronic and regular use of statins, for a period of six months, prevents atrial fibrillation after elective cardiac surgery and claim the the strategy reduced the incidence of atrial fibrillation after elective cardiac surgery. Da Silva et al46 evaluated the effects of nandrolone decanoate on the electrocardiographic profile, glycogen content and total-protein profile of skeletal and cardiac muscles, as well as the plasma albumin concentrations in rats, concluding that major cardiac changes are triggered at an early stage, which indicates a hierarchy in the sequence of changes that compromise the homeostasis of the body.…”

Section: Introductionmentioning

confidence: 99%

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

Patel¹,

Caramelli²,

Gomes³

2011

Clinics

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Recent original scientific contributions published in selected Brazilian periodicals and classifiable under cardiovascular and pulmonary subject categories cover a wide range of sub specialties, both clinical and exprimental. Because they appear in journals with only recently enhanced visibility, we have decided to highlight a number of specific items appeared in four Brazilian journals, because we understand that this is an important subsidy to keep our readership adequately informed. These papers cover extensive sub-areas in both fields.

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“…The authors of the remaining 16 studies were contacted. 3,7,9,[20][21][22][23][24][25][26][27][28][29][30][31][32] Eight authors replied to our emails, 3,7,9,[26][27][28]31,32 but only five were able to provide the required information, 3,7,26,28,32 leaving five studies for potential inclusion in a quantitative analysis. However, in the study by Kourliouros et al, 7 patients were randomised to receive either high-dose (80 mg) or low-dose (10 mg) atorvastatin for seven days prior to cardiac surgery, and as there was no statinnaïve group, i.e.…”

Section: Resultsmentioning

confidence: 99%

Postoperative atrial fibrillation in patients on statins undergoing isolated cardiac valve surgery: a meta-analysis

Drummond

Torborg

Rodseth

et al. 2014

Southern African Journal of Anaesthesia and Analgesia

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The efficacy of perioperative statin therapy in decreasing postoperative morbidity in patients undergoing valve replacements and repairs is unknown. The aim of our study was to determine whether or not the literature supports the hypothesis that statins decrease postoperative atrial fibrillation (AF), and hence improve short-term postoperative outcomes in patients undergoing isolated cardiac valve surgery. Method: We conducted a meta-analysis of studies on postoperative outcomes associated with statin therapy following isolated valve replacement or repair. The data was taken from published studies on valvular heart surgery patients. Participants were patients who underwent either isolated cardiac valve replacement or repair. Patients in the intervention group

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Uso crônico e regular de estatina previne fibrilação atrial no pós-operatório de cirurgia cardíaca

Abstract: Background: Atrial fibrillation is a common complication after cardiac surgery. The previous use of statins may reduce the incidence of this arrhythmia.

Cited by 8 publications

References 29 publications

Serum cholesterol levels and postoperative atrial fibrillation

Serum cholesterol levels and postoperative atrial fibrillation

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

Postoperative atrial fibrillation in patients on statins undergoing isolated cardiac valve surgery: a meta-analysis

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