Using Wolbachia for Dengue Control: Insights from Modelling

Abstract

Dengue is the most common arboviral infection of humans, responsible for a substantial disease burden across the tropics. Traditional insecticide-based vector-control programmes have limited effectiveness, and the one licensed vaccine has a complex and imperfect efficacy profile. Strains of the bacterium Wolbachia, deliberately introduced into Aedes aegyptimosquitoes, have been shown to be able to spread to high frequencies in mosquito populations in release trials, and mosquitoes infected with these strains show markedly reduced vector competence. Thus, Wolbachia represents an exciting potential new form of biocontrol for arboviral diseases, including dengue. Here, we review how mathematical models give insight into the dynamics of the spread of Wolbachia, the potential impact of Wolbachia on dengue transmission, and we discuss the remaining challenges in evaluation and development.

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

“…Multiple traditional measures and strategies have been employed for dengue prevention and control, but most of these are compliance‐ and community involvement–dependent strategies which are hindered by poor compliance and absence of active local community involvement . Modern, integrated vector management approaches using novel biological control approaches such as paratransgenesis, sterile insect techniques, and production of genetically modified vectors, are urgently needed as well as innovative vaccine candidates. Our data presented in this study may be important for dengue vaccine development, particularly with regard to future vaccine composition.…”

Asymmetric synthesis of tetrahydroquinoline‐type ecdysone agonists and QSAR for their binding affinity against Aedes albopictus ecdysone receptors

“…During the optimization, substituents X and Y were fixed to F and 4-Cl, respectively, because this substitution pattern was favored in the preliminary SAR study by Smith et al 24 Among the synthesized compounds (2-17), the unsubstituted compound (2) was the most potent (IC 50 = 63 nmol L -1 ). The introduction of any substituents at the para-position did not enhance the binding affinity (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13), although the CN derivative (10) was equipotent to 2. Various substituents at the meta-position were also examined (14)(15)(16)(17)(18)(19)(20); however, none of them was effective.…”

“…However, Eqn 2 was selected because the collinearity between meta and ΔB 5 meta (r = 0.143) was lower than that between meta and ΔV w meta (r = 0.510). For the combined set of compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), Eqn 3 was formulated:…”

Altered gut microbiota and immunity defines Plasmodium vivax survival in Anopheles stephensi

“…A dominant association of tested Elizabethkingia, Pseudomonas, Serratia with mosquito ovaries/eggs, and subsequent validation of trans ovarian transfer from F1, F2 and F3 generation (See Supplementary data S7), supports an idea to select and target them for future manipulation Alternatively, manipulating intracellular endosymbiont such as Wolbachia induced male sterility and pathogen development inhibition, are rapidly gaining much attention for vector borne disease control program (Bourtzis, Dobson et al 2014;Jayakrishnan, Sudhikumar et al 2018). Trial releases of Wolbachia inhabiting mosquitoes now being proved as a tool to reduce dengue cases in several countries (Dorigatti, McCormack et al 2018;Garcia, Sylvestre et al 2019). A laboratory validation of similar strategy in Anopheline mosquitoes for malaria control is also in progress (Bian, Joshi et al 2013).…”