Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies
Maëlick Brochut,
Tytti Heinonen,
Tiia Snäkä
et al.
Abstract:Preclinical mouse models are critical for understanding the pathophysiological response to infections and developing treatment strategies for sepsis. In keeping with ethical values, researchers follow guidelines to minimize the suffering of the mice. Weight loss is a criteria used as a humane end point, but there is no official recommendation for a maximum weight loss leading to euthanasia. To evaluate whether the thresholds used in daily practice are optimal, we performed a comprehensive retrospective analysi… Show more
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