Using Water-Distribution System Modeling to Assist Epidemiologic Investigations

Maslia, Morris L.; Sautner, J. B.; Aral, Mustafa M.; Reyes, Juan José; Abraham, John; Williams, Robert C.

doi:10.1061/(asce)0733-9496(2000)126:4(180)

Cited by 44 publications

(31 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study in northern New Jersey evaluated leukemia among all ages but found a greater than fourfold excess of leukemia among female children aged less than 5 years old exposed to TCEcontaminated drinking water (Cohn et al 1994); no excess of leukemia was observed for male children. Waterdistribution system modeling was conducted for a casecontrol study of childhood cancers in Dover Township Bove et al (2002) b Results set in bold type indicate those that were calculated by the reviewing authors (Bove et al 2002) OR, odds ratio; TCE, trichloroethylene; PCE, tetrachloroethylene; MDPH, Massachusetts Department of Public Health; SGA, small for gestational age; LBW, low birth weight; NTD, neural tube defects; MBW, mean birth weight; VLBW, very low birth weight; MBWD, mean birth weight difference; GIS, geographic information system; =, equals; ≤, less than or equal to; −, negative; g, gram; yr, year (Toms River), New Jersey, to estimate the percentage of water from each wellfield serving each child's residence (Maslia et al 2000(Maslia et al , 2001. Maternal residences during pregnancy that received water most of the time (i.e., ≥50% of the time each month) from a public wellfield contaminated with TCE, PCE and a styrene acrylonitrile trimer were associated with a fivefold excess in leukemia among females; no excess was seen in male children (NJDHSS 2003).…”

Section: Review Of Voc-related Health Studiesmentioning

confidence: 99%

Reconstructing Historical Exposures to Volatile Organic Compound-Contaminated Drinking Water at a U.S. Military Base

Maslia

Aral

Faye³

et al. 2009

Water Expo. Health

View full text Add to dashboard Cite

Two of three water-distribution systems that have historically supplied drinking water to family housing at U.S. Marine Corps Base Camp Lejeune, North Carolina, were contaminated with volatile organic compounds (VOCs). Scientific data relating to the harmful effects of VOCs on a child or fetus are limited. Therefore, the U.S. Agency for Toxic Substances and Disease Registry (ATSDR) is conducting an epidemiological study to evaluate potential associations between in utero and infant (up to 1 year of age) exposures to VOCs in contaminated drinking water at Camp Lejeune and specific birth defects and childhood cancers. The study includes births that occurred during the period 1968-1985 to women who were pregnant while they resided in family housing at Camp Lejeune. To support

show abstract

Section: Review Of Voc-related Health Studiesmentioning

confidence: 99%

Reconstructing Historical Exposures to Volatile Organic Compound-Contaminated Drinking Water at a U.S. Military Base

Maslia

Aral

Faye³

et al. 2009

Water Expo. Health

View full text Add to dashboard Cite

show abstract

“…Drinking water concentrations are obtained from regulatory monitoring databases (such as SDWIS/FED-USEPA, 2006a) or field study measurements (such as the National Human Exposure Assessment Survey (NHEXAS)- Thomas et al, 1999;Pellizzari and Clayton, 2006). If such data are not available, the drinking water distributions are modeled using the EPANET2 model (Rossman, 2000) with treatment plant data to obtain drinking water concentrations (see e.g., Maslia et al, 2000 for a discussion of application of drinking water distribution modeling to epidemiological studies).…”

mentioning

confidence: 99%

Biologically based modeling of multimedia, multipathway, multiroute population exposures to arsenic

Georgopoulos

Wang

et al. 2007

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

This article presents an integrated, biologically based, source-to-dose assessment framework for modeling multimedia/multipathway/multiroute exposures to arsenic. Case studies demonstrating this framework are presented for three US counties (Hunderton County, NJ; Pima County, AZ; and Franklin County, OH), representing substantially different conditions of exposure. The approach taken utilizes the Modeling ENvironment for TOtal Risk studies (MENTOR) in an implementation that incorporates and extends the approach pioneered by Stochastic Human Exposure and Dose Simulation (SHEDS), in conjunction with a number of available databases, including NATA, NHEXAS, CSFII, and CHAD, and extends modeling techniques that have been developed in recent years. Model results indicate that, in most cases, the food intake pathway is the dominant contributor to total exposure and dose to arsenic. Model predictions are evaluated qualitatively by comparing distributions of predicted total arsenic amounts in urine with those derived using biomarker measurements from the NHEXAS -Region V study: the population distributions of urinary total arsenic levels calculated through MENTOR and from the NHEXAS measurements are in general qualitative agreement. Observed differences are due to various factors, such as interindividual variation in arsenic metabolism in humans, that are not fully accounted for in the current model implementation but can be incorporated in the future, in the open framework of MENTOR. The present study demonstrates that integrated source-to-dose modeling for arsenic can not only provide estimates of the relative contributions of multipathway exposure routes to the total exposure estimates, but can also estimate internal target tissue doses for speciated organic and inorganic arsenic, which can eventually be used to improve evaluation of health risks associated with exposures to arsenic from multiple sources, routes, and pathways.

show abstract

“…EPANET is a water transport algorithm developed by the United States Environmental Protection Agency (EPA) for water monitoring programs and utilized in epidemiologic studies evaluating the health effects of drinking water contaminants [25, 26]. It estimates water flow dynamics (rate and direction) using inputs of the pipe configuration and number of water users throughout a town’s entire public water distribution network.…”

Section: Methodsmentioning

confidence: 99%

Association of prenatal and early life exposure to tetrachloroethylene (PCE) with polycystic ovary syndrome and other reproductive disorders in the cape cod health study: A retrospective cohort study

Mahalingaiah

Winter

Aschengrau

2016

Reproductive Toxicology

View full text Add to dashboard Cite

Background Tetrachloroethylene (PCE) is an organic lipophilic solvent with possible neuroendocrine toxicity. The objective of this study was to determine the association of prenatal and early childhood exposure to PCE-contaminated drinking water and development of adult-onset Polycystic Ovary Syndrome (PCOS), endometriosis, difficulty conceiving and miscarriage. Methods Five-hundred exposed and 331 unexposed female participants born between 1969 and 1983 completed questionnaires on demographic and lifestyle characteristics, and reproductive disorders. Residential locations from the prenatal period through five years of age were used to estimate early life PCE exposure with water modeling software. Results For any early life exposure to PCE, the adjusted risk ratio for PCOS was 0.9 (95% CI: 0.5–1.6). No statistically significant associations were observed for increasing levels of exposure with PCOS or the other reproductive disorders. Conclusion No meaningful associations were found among adult women with early life exposure to PCE-contaminated drinking water and adult-onset reproductive disorders.

show abstract

Using Water-Distribution System Modeling to Assist Epidemiologic Investigations

Cited by 44 publications

References 10 publications

Reconstructing Historical Exposures to Volatile Organic Compound-Contaminated Drinking Water at a U.S. Military Base

Reconstructing Historical Exposures to Volatile Organic Compound-Contaminated Drinking Water at a U.S. Military Base

Biologically based modeling of multimedia, multipathway, multiroute population exposures to arsenic

Association of prenatal and early life exposure to tetrachloroethylene (PCE) with polycystic ovary syndrome and other reproductive disorders in the cape cod health study: A retrospective cohort study

Contact Info

Product

Resources

About