Using visual processing training to enhance standard cognitive remediation outcomes in schizophrenia: A pilot study

Contreras, Natalia A.; Tan, Eric J.; Lee, Stuart; Castle, David; Rossell, Susan L.

doi:10.1016/j.psychres.2017.09.031

Cited by 14 publications

(11 citation statements)

References 39 publications

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“…Our intention is to position the current study within the broader context of prevailing cognitive research in psychosis, acknowledging inherent complexities therein. Studies have shown that targeted remediation of cognitive deficits has demonstrated efficacy (19‐21) in schizophrenia spectrum disorders, and may in turn, convey direct therapeutic benefits to patients with AVHs (though substantial deficits may remain despite moderate improvements). Yet to date, there has been scant research examining specific cognitive profiles associated with voice symptoms.…”

Section: Introductioncontrasting

confidence: 64%

Identifying the cognitive underpinnings of voice‐hearing by comparing never, past and current voice‐hearers

Toh

Tan

Neill

et al. 2020

Acta Psychiatr Scand

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Objective The current study aimed to compare specific cognitive profiles corresponding to auditory verbal hallucinations (AVH) status and elucidate which pattern of cognitive deficits may predict voice‐hearing status. Method Clinical participants with schizophrenia spectrum disorders were partitioned into: (i) current voice‐hearers (n = 46), (ii) past voice‐hearers (n = 37) and (iii) never voice‐hearers (n = 40), and compared with 319 non‐clinical controls. Cognitive assessment employed the MATRICS Consensus Cognitive Battery (MCCB), supplemented by the Delis–Kaplan Executive Function System (D‐KEFS) Colour–Word Interference Test (Stroop) as a robust measure of executive function. Results On the Visual Learning domain, current and past voice‐hearers had significantly poorer performance relative to never voice‐hearers, who in turn had significantly poorer performance than non‐clinical controls. Current and never voice‐hearers had significantly poorer performance on the Social Cognition domain relative to non‐clinical controls. Current voice‐hearers also had significantly poorer performance on the Inhibition domain relative to non‐clinical controls. Binary logistic regression revealed that Visual Learning was the only significant cognitive predictor of AVH presence. Conclusion Visual learning, and potentially inhibition, may be viable therapeutic targets when addressing cognitive mechanisms associated with AVHs. Future research should focus on investigating additional cognitive mechanisms, employing diverse voice‐hearing populations and embarking on related longitudinal studies.

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Section: Introductioncontrasting

confidence: 64%

Identifying the cognitive underpinnings of voice‐hearing by comparing never, past and current voice‐hearers

Toh

Tan

Neill

et al. 2020

Acta Psychiatr Scand

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“…Nevertheless, the lingual gyrus was significantly associated with anti-psychotic medication, therefore indicating that this region may be particularly prone to alterations when exposed to medication. The lingual gyrus is involved mainly in visual processing Psychological Medicine 7 (Hahn, Ross, & Stein, 2006;Lee, Hong, Seo, Tae, & Hong, 2000) which has been shown to be impaired in psychosis (see Butler, Silverstein, & Dakin, 2008;Silverstein & Keane, 2011 for a review) and are also thought to underlie some of the cognitive impairments characteristic of the illness (Contreras, Tan, Lee, Castle, & Rossell, 2018;Surti & Wexler, 2012;Surti, Corbera, Bell, & Wexler, 2011). The lingual gyrus also contributes to the evaluation of emotional faces (Fusar-Poli et al, 2009) which, together with the deficits found in the fusiform gyrus, may explain social cognition impairments in psychosis (Green et al, 2015).…”

Section: Lingual Gyrusmentioning

confidence: 99%

Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis

et al. 2019

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Background Neuroanatomical abnormalities in first-episode psychosis (FEP) tend to be subtle and widespread. The vast majority of previous studies have used small samples, and therefore may have been underpowered. In addition, most studies have examined participants at a single research site, and therefore the results may be specific to the local sample investigated. Consequently, the findings reported in the existing literature are highly heterogeneous. This study aimed to overcome these issues by testing for neuroanatomical abnormalities in individuals with FEP that are expressed consistently across several independent samples. Methods Structural Magnetic Resonance Imaging data were acquired from a total of 572 FEP and 502 age and gender comparable healthy controls at five sites. Voxel-based morphometry was used to investigate differences in grey matter volume (GMV) between the two groups. Statistical inferences were made at p < 0.05 after family-wise error correction for multiple comparisons. Results FEP showed a widespread pattern of decreased GMV in fronto-temporal, insular and occipital regions bilaterally; these decreases were not dependent on anti-psychotic medication. The region with the most pronounced decrease – gyrus rectus – was negatively correlated with the severity of positive and negative symptoms. Conclusions This study identified a consistent pattern of fronto-temporal, insular and occipital abnormalities in five independent FEP samples; furthermore, the extent of these alterations is dependent on the severity of symptoms and duration of illness. This provides evidence for reliable neuroanatomical alternations in FEP, expressed above and beyond site-related differences in anti-psychotic medication, scanning parameters and recruitment criteria.

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“…Twenty-three studies included a computerized CRT program with dropout rates ranging from 0 to 53 [ 7 , 8 , 10 , 11 , 12 , 13 , 14 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. One study compared paper-and-pencil and computerized CRT to one another and had 9 total dropouts [ 25 ]. It is unclear from these results if computerized CRT programs are superior to paper-and-pencil.…”

Section: Resultsmentioning

confidence: 99%

“…Both group and individual formats implementing CRT were found from our search. Of the 26 articles, nine studies used an individual format [ 7 , 11 , 12 , 13 , 14 , 23 , 24 , 29 , 31 ] and 17 used a group format [ 8 , 9 , 10 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 25 , 26 , 27 , 28 , 30 , 32 ]. One study [ 22 ] had participants complete homework exercises in their own homes, but the CRT program itself was implemented in a group outpatient setting.…”

Section: Resultsmentioning

confidence: 99%

Advances in Cognitive Remediation Training in Schizophrenia: A Review

Fitapelli

Lindenmayer

2022

Brain Sciences

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Cognitive Remediation Training (CRT) in schizophrenia has made great strides since its introduction in the 1990s. CRT was developed with the aim of improving the everyday functioning of individuals living with cognitive impairment. MEDLINE, PsychINFO, and Google Scholar were searched to extract peer-reviewed randomized controlled trials to produce the current review article. The aim of the present review is to summarize CRT effects on addressing cognitive changes in patients undergoing CRT as defined by the Cognitive Remediation Experts Workshop and to describe the areas of greatest impact in specific cognitive domains. Another area of this review aims to summarize the modalities of intervention (paper and pencil; computerized; home bound), the persistence of improvements, and their generalization to other domains of functioning. Finally, this review delineates barriers for wider dissemination of CRT, such as the transfer of research findings into clinical everyday practice and future developments of CRT.

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Using visual processing training to enhance standard cognitive remediation outcomes in schizophrenia: A pilot study

Cited by 14 publications

References 39 publications

Identifying the cognitive underpinnings of voice‐hearing by comparing never, past and current voice‐hearers

Identifying the cognitive underpinnings of voice‐hearing by comparing never, past and current voice‐hearers

Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis

Advances in Cognitive Remediation Training in Schizophrenia: A Review

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