Background and ObjectivesClear aligners‐related posts are popularized on social media platforms to educate patients and peers and to market aligners in dental practices. This study aimed to characterize the account credentials and content of the top‐performing posts to understand the spread of clear aligners‐related information on Instagram.Materials and MethodsThis cross‐sectional web‐based study analysed 13 Instagram clear aligners‐related hashtags. Content analysis was performed for the “Top 10 posts” listed under the “Top” section for each hashtag within Instagram, as sorted by Instagram's algorithm. Data were analysed for the poster's background, credentials, role, post format, content, and engagement level ratio. Duplicate posts and those not relevant to clear aligners were excluded. Quantitative and qualitative analyses of the collected data were conducted.ResultsA total of 29 192 596 posts mentioned the selected hashtags, of which 130 posts were screened in this study. Most posts were authored by dentists (n = 84), 79.8% of them were orthodontic specialists. Self‐promotional posts comprised 90.2%, while educational posts accounted for only 8.9%. Interestingly, the number of likes and comments received on posts by patients (n = 19, median = 112, IQR = 340) was significantly higher than those posted by dentists (n = 84, median = 93, IQR = 81.75) (P = .004).ConclusionMore than 29 million posts about clear aligners were identified on Instagram. Orthodontists are the leading authors of aligners hashtags. However, the majority of the posts are self‐promotional and have nonfactual information. Social media awareness among orthodontic specialists may help provide more evidence‐based content about clear aligners and can act as an interactive networking and health communication platform.