Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model

Braun, Phillip X.; Mehta, Nihaal; Gendelman, Isaac; Alibhai, A. Yasin; Baumal, Caroline R.; Duker, Jay S.; Waheed, Nadia K.

doi:10.1167/tvst.9.8.44

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…Laiginhas et al recently postulated that local thresholding strategies, such as Phansalkar or others, are significantly superior to global ones, such as Otsu or others, for quantifying CC and should be preferred 34 . However, direct comparisons between different strategies should not be performed 35 . So far, there has been no consensus on binarization practice and numerous studies have shown that different binarization methods resulted in significantly different FD measures.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen

Clemens

Lauermann

Schmitz

et al. 2021

Sci Rep

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To determine longitudinal changes in choriocapillaris (CC) measures in eyes with reticular pseudodrusen (RPD) using optical coherence tomography angiography (OCTA). In this observational prospective study, 20 patients with exclusively RPD and no other alteration due to age-related macular degeneration were included. Eight RPD patients were re-examined at 5-year follow-up. Multimodal imaging was performed at baseline and at 5-year follow-up. OCTA CC images were analyzed for number, size and total area of flow deficits (FD), mean signal intensity, signal intensity standard deviation and kurtosis of signal intensity distribution in the ring area between a circle of 4 mm diameter and a circle of 6 mm diameter and in the superior ring quadrant. Area affected by RPD increased from 19.36 ± 8.39 mm2 at baseline to 37.77 ± 9.03 mm2 at 5-year follow-up. At baseline, percent of CC FD area was greater in RPD eyes (quadrant: p < 0.001; ring: p < 0.001) compared to controls. Besides, RPD eyes revealed a lower mean intensity signal (quadrant: p < 0.001; ring: p < 0.001). Evaluation of CC parameters suggested significant group × time interaction effects for CC FD (p = 0.04) and mean intensity signal (p = 0.004), in that RPD eyes presented increased CC FD and decreased mean intensity signal at follow-up. OCTA CC decorrelation signal further decreases in RPD patients over 5 years in both RPD-affected and RPD-unaffected macular areas.

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Section: Discussionmentioning

confidence: 99%