Using the method of laser spectroscopy in the evaluation of the therapy effectiveness in patients with severe bronchial asthma

Abstract

Because of the shortcomings of existing methods of assessment of inflammation activity in the airways, the method of laser optic-acoustic spectroscopy of patients expired air considered using for this purpose. This method can be used to indirectly evaluate the activity of inflammation in the airways and as an additional criterion for the effectiveness of basic treatment in patients with asthma.

Diagnostics and forecasting of non-controlled bronchial asthma

“…It is known that non-controlled asthma presents various clinical, functional and pathophysiological phenotypes and endotypes (brittle or fragile, nocturnal asthma, steroid-sensitive and steroid-resistant asthma, asthma with fixed bronchial obstruction, premenstrual, acute severe asthma, status asthmaticus, fatal asthma, etc.). It is caused by different mechanisms of its formation [5], [14], [45], [59], [62] and therefore requires different approaches to diagnosis and forecasting.…”

“…Numerous studies have shown that validated questionnaires such as c-ACT questionnaire and ACQ-5 test provide standardized quantitative assessment of controllability of asthma, correlated with the GINA criteria, instrumental methods of examination of patients with markers of inflammation: clinical test for the assessment of controllability of asthma ACQ-5 provides best results in short term (weeks), and ACT -in long term (a month or more) [4], [5], [7], [11], [16], [49].…”