Using the Human Gastrointestinal Microbiome to Personalize Nutrition Advice: Are Registered Dietitian Nutritionists Ready for the Opportunities and Challenges?

Harvie, Ruth; Chanyi, Ryan M.; Burton, Jeremy P.; Schultz, Michael

doi:10.1016/j.jand.2016.10.020

Cited by 6 publications

(3 citation statements)

References 53 publications

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“…The wide natural variation in the microbiome combined with an infrastructure failure meant we were unable to detect a change in the composition and diversity of the microbiome. Future dietary interventions investigating the effect of diet on the microbiome may benefit from including metabolomics[ 68 ]. McIntosh et al[ 27 ] found greater separation between a low FODMAP and a high FODMAP diet in the metabolome than the microbiome.…”

Section: Discussionmentioning

confidence: 99%

Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs

Harvie

Chisholm

Bisanz

et al. 2017

WJG

Self Cite

111

152

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AIMTo investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol (FODMAP) diet on irritable bowel syndrome (IBS) symptoms and quality of life (QoL).METHODSParticipants with IBS (Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS (IBS symptom severity scoring system, 0-500 points increasing with severity), IBS QoL questionnaire (0-100 increasing with QoL), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTSFifty participants were enrolled into group I (n = 23) or group II (n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS (275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1) (P < 0.0002) and increased QoL (68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4) (P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I (160 ± 102) and replicated in group II (124 ± 76). Fiber intake decreased on the low FODMAP diet (33 ± 17 g/d to 21 ± 8 g/d) (P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSIONThis study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs.

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Section: Discussionmentioning

confidence: 99%

Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs

Harvie

Chisholm

Bisanz

et al. 2017

WJG

Self Cite

111

152

View full text Add to dashboard Cite

show abstract

“…Nonetheless, translation of microbiome research into practical applications by clinicians remains a formidable challenge. As discussed by several investigators (Harvie et al 2017, Lockwood & Green 2020, there is a need to educate clinicians on the potential of using microbiome-derived data in clinical care settings that can be applied toward developing personalized recommendations that are realistic and relevant to patients. Therefore, long-term efforts will be needed to consolidate findings across fields of nutrition, dietetics, food science, genetics, and epigenetics to gain comprehensive insights into the integration of holistic approaches to patient care.…”

Section: Discussionmentioning

confidence: 99%

Predicting Personalized Responses to Dietary Fiber Interventions: Opportunities for Modulation of the Gut Microbiome to Improve Health

Kok

Rose

Hutkins

2023

Annu. Rev. Food Sci. Technol.

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Inadequate dietary fiber consumption has become common across industrialized nations, accompanied by changes in gut microbial composition and a dramatic increase in chronic metabolic diseases. The human gut microbiome harbors genes that are required for the digestion of fiber, resulting in the production of end products that mediate gastrointestinal and systemic benefits to the host. Thus, the use of fiber interventions has attracted increasing interest as a strategy to modulate the gut microbiome and improve human health. However, considerable interindividual differences in gut microbial composition have resulted in variable responses toward fiber interventions. This variability has led to observed nonresponder individuals and highlights the need for personalized approaches to effectively redirect the gut ecosystem. In this review, we summarize strategies used to address the responder and nonresponder phenomenon in dietary fiber interventions and propose a targeted approach to identify predictive features based on knowledge of fiber metabolism and machine learning approaches. Expected final online publication date for the Annual Review of Food Science and Technology, Volume 14 is March 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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“…48,49 However, to incorporate findings from the gut microbiome into clinical practice, RDNs must understand the data that are being generated by specific patient cohorts through microbiome analysis. As summarized by Harvie and colleagues, 56 "the RDN's role in collaborations investigating the microbiome will be to design dietary interventions, provide the dietary education to patients, ensure food composition data are available for the nutrient of interest, and measure dietary intake and adherence to the interventions. "…”

Section: Future Opportunities For Nutritional Modulation Of the Gut Mmentioning

confidence: 99%

Introduction to the special focus issue on the impact of diet on gut microbiota composition and function and future opportunities for nutritional modulation of the gut microbiome to improve human health

Donovan

2017

Gut Microbes

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Over the past decade, application of culture-independent, next generation DNA sequencing has dramatically enhanced our understanding of the composition of the gut microbiome and its association with human states of health and disease. Host genetics, age, and environmental factors such as where and who you live with, use of pre-, pro- and antibiotics, exercise and diet influence the short- and long-term composition of the microbiome. Dietary intake is a key determinant of microbiome composition and diversity and studies to date have linked long-term dietary patterns as well as short-term dietary interventions to the composition and diversity of the gut microbiome. The goal of this special focus issue was to review the role of diet in regulating the composition and function of the gut microbiota across the lifespan, from pregnancy to old age. Overall dietary patterns, as well as perturbations such as undernutrition and obesity, as well as the effects of dietary fiber/prebiotics and fat composition are explored.

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Using the Human Gastrointestinal Microbiome to Personalize Nutrition Advice: Are Registered Dietitian Nutritionists Ready for the Opportunities and Challenges?

Cited by 6 publications

References 53 publications

Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs

Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs

Predicting Personalized Responses to Dietary Fiber Interventions: Opportunities for Modulation of the Gut Microbiome to Improve Health

Introduction to the special focus issue on the impact of diet on gut microbiota composition and function and future opportunities for nutritional modulation of the gut microbiome to improve human health

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