2014
DOI: 10.1309/ajcpcvz5b0boyjgn
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Using the Hemoglobin Content of Reticulocytes (RET-He) to Evaluate Anemia in Patients With Cancer

Abstract: Objectives Evaluation of anemia, particularly iron deficiency, in patients with cancer is difficult. This study examined using the hemoglobin content of reticulocytes (RET-He) to rule out iron deficiency, as defined by serum iron studies (transferrin saturation <20%, serum iron <40 µg/ dL, and ferritin <100 ng/mL), in an unselected cancer patient population. Methods Patients were entered into the study based on the existence of concurrent laboratory test requests for CBC and serum iron studies. Results Usi… Show more

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Cited by 33 publications
(47 citation statements)
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“…The sensitivity, however, was poorer when compared to reported diagnostic iron studies (sensitivity of 90.0%), soluble transferrin receptor (sensitivity of 86%), and recent studies of Ret‐He . Ret‐He has been widely studied, within numerous population groups including pregnancy . The reported diagnostic Ret‐He cutoff values vary from 27 to 32 pg according to the study population and diagnostic inclusion criteria .…”
Section: Discussionmentioning
confidence: 91%
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“…The sensitivity, however, was poorer when compared to reported diagnostic iron studies (sensitivity of 90.0%), soluble transferrin receptor (sensitivity of 86%), and recent studies of Ret‐He . Ret‐He has been widely studied, within numerous population groups including pregnancy . The reported diagnostic Ret‐He cutoff values vary from 27 to 32 pg according to the study population and diagnostic inclusion criteria .…”
Section: Discussionmentioning
confidence: 91%
“…Patients on iron supplementation, with a history of blood transfusion in the last 3 months or with an Hb <11 g/dL, were excluded. Participants were also excluded if they had a MCV >100 fL or a diagnosis of a hemoglobinopathy . Thalassemia screening was performed by measurement of the RBC indices.…”
Section: Methodsmentioning
confidence: 99%
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“…Smernice tako priporočajo spremljanje razpoložljivosti železa s pomočjo parametra CHr pri bolnikih s KLB. Napačni odmerki epoetinov in pripravkov železa pri zdravljenju AKLB vodijo do nastanka SDA in funkcionalnega pomanjkanja železa, lahko pa tudi do pretirane preobremenitve z žele-zom (3,13,22).V naši raziskavi smo potrdili dobro ujemanje parametrov Ret-He in CHr (Slika 1), kar je v skladu z rezultati drugih raziskav, ki so potrdile linearno korelacijo in popolno medsebojno primerljivost parametrov pri oceni pomanjkanja železa (15,17,18,23). Nekoliko slabšo povezavo med parametroma smo opazili v območju znižanih vrednosti (<30 pg), kar gre pripisati vključenosti manjšega števila bolnikov s SDA.…”
Section: Razpravljanjeunclassified