Using the Electronic Medical Record to Correlate Kawasaki Disease Phenotypes With Clinical Outcomes

Jaggi, Preeti; Grcic, Michelle; Kovalchin, John P.; Wilhelm, Carolyn M.; Yildirim‐Toruner, Cagri; Texter, Karen

doi:10.1093/jpids/pix016

Cited by 2 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our retrospective investigation, the incidence of initial IVIG resistance was about 11.9 % (112/940), and the rate of repeated IVIG resistance was about 4.2 % (40/940). It has been reported that age less than 3 months, incomplete KD, incidence of CAA and initial administration of IVIG ≤ 4.0 days were associated with initial IVIG resistance [15,16]. But, these clinical data were not associated with repeated IVIG resistance in our research.…”

Section: Discussioncontrasting

confidence: 66%

Prediction of repeated intravenous immunoglobulin resistance in children with Kawasaki disease

et al. 2021

View full text Add to dashboard Cite

Background Repeated intravenous immunoglobulin (IVIG) resistance prediction is one of the pivotal topics in Kawasaki disease (KD). Those non-responders of repeated IVIG treatment might be improved by an early-intensified therapy to reduce coronary artery lesion and medical costs. This study investigated predictors of resistance to repeated IVIG treatment in KD. Methods A total of 94 children with IVIG-resistant KD treated at our hospital between January 2016 and August 2020 were retrospectively analyzed. According to the therapeutic effect of a second dose IVIG treatment, the children were divided into repeated IVIG-responsive group and repeated IVIG-resistant group, and the clinical and laboratory data were compared. Predictors of repeated IVIG resistance and the optimal cut-off value were determined by multiple logistic regression analysis and receiver operating characteristic (ROC) curve analysis. Results The Pre-IVIG laboratory data showed the percentage of neutrophils (N%) and levels of serum procalcitonin (PCT), N-terminal pro-brain natriuretic peptide (NT-proBNP) were significantly higher in repeated IVIG-resistant group compared with repeated IVIG-responsive group, while levels of serum sodium and albumin (ALB) were significantly lower (P < 0.05). The post-IVIG laboratory values of N% and C-reactive protein (CRP) were significantly higher in the repeated IVIG-resistant group compared with repeated IVIG-responsive group, while hemoglobin and ALB were lower (P < 0.05). Pre-IVIG PCT and post-IVIG CRP exhibited AUC of 0.751 and 0.778 respectively in predicting repeated IVIG resistance in KD. Pre-IVIG PCT > 1.81ng/ml (OR 4.1, 95 % CI 1.4 ~ 12.0, P < 0.05) and post-IVIG CRP > 45 mg/L (OR 4.6, 95 % CI 1.3 ~ 16.2, P < 0.05) were independent predictors of repeated IVIG resistance in KD. Conclusions Our study illustrates the serum PCT level before initial IVIG treatment and CRP after initial IVIG could be used to predict repeated IVIG resistance in KD.

show abstract

Section: Discussioncontrasting

confidence: 66%

Prediction of repeated intravenous immunoglobulin resistance in children with Kawasaki disease

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In our retrospective investigation, the incidence of initial IVIG resistance was about 11.91% (112/940), and the rate of repeated IVIG resistance was about 4.25% (40/940). It has been reported that age less than 3 months, incomplete KD, incidence of CAA and initial administration of IVIG ≤ 4.0 days were associated with initial IVIG resistance [27][28][29][30][31]. The hypercoagulation of increased APTT, PT and D-dimer and the abnormal liver function of increased ALT, AST, TB were con rmed as the risk factors favor initial IVIG resistance [22,[32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Prediction of Repeated Intravenous Immunoglobulin Resistance in Children With Kawasaki Disease

Lü

Chen

Wen

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Repeated intravenous immunoglobulin (IVIG) resistance prediction is one of the pivotal topics in Kawasaki disease (KD). Those non-responders of repeated IVIG treatment might be improved by an early-intensified therapy to reduce coronary artery lesion and medical costs. This study investigated predictors of resistance to repeated IVIG treatment in KD.Methods: A total of 94 children with IVIG-resistant KD treated at our hospital between January 2016 and August 2020 were retrospectively analyzed. According to the therapeutic effect of a second dose IVIG treatment, the children were divided into repeated IVIG-responsive group and repeated IVIG-resistant group, and the clinical and laboratory data were compared. Predictors of repeated IVIG resistance and the optimal cut-off value were determined by multiple logistic regression analysis and receiver operating characteristic (ROC) curve analysis.Results: The laboratory data of the percentage of neutrophils (N%) and levels of serum procalcitonin (PCT), N-terminal pro-brain natriuretic peptide (NT-proBNP) on admission were significantly higher in repeated IVIG-resistant group compared with repeated IVIG-responsive group, while levels of serum sodium (Na+) and albumin (ALB) were significantly lower (P<0.05). The clinic data showed no significant differences between the two groups. PCT exhibited the largest AUC (0.751) in predicting repeated IVIG resistance in KD compared with N%, Na+, ALB, and NT-proBNP. PCT>1.81ng/ml was an independent predictor of repeated IVIG resistance in KD (OR 4.161, 95% CI 1.441~12.017, P=0.008). Conclusions: Our study illustrates the serum PCT level before initial IVIG treatment could be used to predict repeated IVIG resistance in KD.

show abstract

Using the Electronic Medical Record to Correlate Kawasaki Disease Phenotypes With Clinical Outcomes

Cited by 2 publications

References 19 publications

Prediction of repeated intravenous immunoglobulin resistance in children with Kawasaki disease

Prediction of repeated intravenous immunoglobulin resistance in children with Kawasaki disease

Prediction of Repeated Intravenous Immunoglobulin Resistance in Children With Kawasaki Disease

Contact Info

Product

Resources

About