Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake

Abstract

List of Abbreviations: f D , dynamic free fraction; PS int,u , unbound intrinsic uptake clearance; PS int , intrinsic uptake clearance; WSM, well-stirred clearance model; dWSM, dynamic wellstirred model; f u , fraction of unbound; LC-HRMS liquid chromatography high resolution mass spectrometry.