Using the Androgen Excess–PCOS Society Criteria to Diagnose Polycystic Ovary Syndrome and the Risk of Metabolic Syndrome in Adolescents

Roe, Andrea H.; Prochaska, Erica; Smith, Matthew; Sammel, Mary D.; Dokras, Anuja

doi:10.1016/j.jpeds.2012.11.019

Cited by 58 publications

(46 citation statements)

References 21 publications

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“…In a study of 205 adolescents (≤20 years), the presence of metabolic risk factors and metabolic syndrome was investigated. The prevalence of being overweight or obese was significantly higher in adolescents with PCOS compared with those without (60% vs. 18%) (42).…”

Section: Pathogenesis Of Metabolic Syndrome In Adolescent Pcos Womenmentioning

confidence: 87%

What do we know about metabolic syndrome in adolescents with PCOS?

Cırık

Dilbaz

2014

J Turkish German Gynecol Assoc

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Section: Pathogenesis Of Metabolic Syndrome In Adolescent Pcos Womenmentioning

confidence: 87%

What do we know about metabolic syndrome in adolescents with PCOS?

Cırık

Dilbaz

2014

J Turkish German Gynecol Assoc

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“…In addition, overweight and obesity are commonly found in adolescents with PCOS and confer their own risk (33). Metabolic syndrome, impaired glucose tolerance, and type 2 diabetes are all more frequent in adolescents with PCOS (30,(34)(35)(36)(37), and patients should be screened for their presence. The 2-hour plasma glucose level after an oral glucose challenge appears to be the most reliable screening test for abnormalities in glucose tolerance, and some authors have recommended periodic screening for abnormal glucose tolerance using the 2-hour oral glucose tolerance test in adolescents with PCOS (38).…”

Section: Evaluation For Comorbiditymentioning

confidence: 99%

Polycystic ovary syndrome in adolescence: diagnostic and therapeutic strategies

Kamboj

Bonny

2017

Transl. Pediatr

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Controversy continues about the underlying etiopathogenesis, diagnostic criteria, and recommendations for polycystic ovary syndrome (PCOS) in adolescents. Recent literature has recognized these deficiencies and evidence based expert recommendations have become more available. The purpose of this chapter is to offer primary care providers a practical understanding and approach to the diagnosis and treatment of PCOS in adolescents. Although the presence of polycystic ovary morphology (PCOM) is included as a key diagnostic criterion of PCOS in adults, it is currently not recommended for the diagnosis in adolescents. As such, the diagnosis of PCOS in adolescents currently hinges on evidence of ovulatory dysfunction and androgen excess. Recommended evidence of ovulatory dysfunction includes: consecutive menstrual intervals >90 days even in the first year after menstrual onset; menstrual intervals persistently <21 or >45 days 2 or more years after menarche; and lack of menses by 15 years or 2-3 years after breast budding. Recommended evidence of androgen excess include: moderate to severe hirsutism; persistent acne unresponsive to topical therapy; and persistent elevation of serum total and/or free testosterone level. Importantly, a definitive diagnosis of PCOS is not needed to initiate treatment. Treatment may decrease risk of future comorbidity even in the absence of a definitive diagnosis. Deferring diagnosis, while providing symptom treatment and regular/ frequent follow-up of symptomology, is a recommended option.The treatment options for PCOS should be individualized to the presentation, needs, and preferences of each patient. Goals of treatment are to improve quality of life and long-term health outcomes. Lifestyle modifications remain first-line management of overweight and obese adolescents with PCOS. Combined oral contraceptives (COC) are first line pharmacotherapy for management of menstrual irregularity and acne, and metformin is superior to COCs for weight reduction and improved dysglycemia. COCs and metformin have similar effects on hirsutism, but often need to be paired with other treatment modalities to achieve further improvement of cutaneous symptoms. Clinicians should be cognizant that PCOS is associated with significant metabolic and psychological comorbidity and screen for these issues appropriately.

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“…The diagnosis of PCOS and hyperandrogenism is challenging in adolescence, due to the physiological endocrine perturbations typical of this period, which make it difficult to distinguish transient para-physiological impairments of the hypothalamuspituitary-gonadal axis from frankly pathological conditions [88•]. However, it has been proposed recently that the Androgen Excess -PCOS Society criteria for the diagnosis of PCOS in adults (clinical and/or biochemical hyperandrogenism + ovulatory disfunction + polycystic ovary) may be adequate for adolescent girls as well [89].…”

Section: Pcosmentioning

confidence: 99%

“…Adolescent girls with PCOS have significantly higher rates of perturbations of glucose metabolism, mainly IGT [89][90][91], and are at increased risk of hypertension [92] and MS [89,93], compared to their healthy counterparts. IR and metabolic perturbations are more prevalent in obese than in non obese girls with PCOS [89,91,92] and increased androgens in obese girls with PCOS have been associated with increased cIMT [28].…”

Section: Pcosmentioning

confidence: 99%

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Metabolic Issues in Adolescence

Morandi

Maffeis

2013

Curr Obes Rep

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The prevention, diagnosis and treatment of obesityinduced metabolic conditions are cornerstones of the management of overweight and obesity in adolescents. This paper reviews important new evidence in the field of the metabolic issues concerning the obese adolescent, with particular focus on epidemiological and clinical aspects. Current concepts and controversies regarding metabolic syndrome (MS), MS components and novel metabolic markers will be discussed, as well as two other conditions that increase the metabolic and cardiovascular risk in obese adolescents: polycystic ovary syndrome and non alcoholic fatty liver disease.

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Using the Androgen Excess–PCOS Society Criteria to Diagnose Polycystic Ovary Syndrome and the Risk of Metabolic Syndrome in Adolescents

Cited by 58 publications

References 21 publications

What do we know about metabolic syndrome in adolescents with PCOS?

What do we know about metabolic syndrome in adolescents with PCOS?

Polycystic ovary syndrome in adolescence: diagnostic and therapeutic strategies

Metabolic Issues in Adolescence

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