This study assessed feasibility and patient acceptance and estimated the magnitude of the clinical impact of physical telerehabilitation in patients with multiple sclerosis (MS). We recruited 12 consecutive patients with a known diagnosis of MS. Each patient received a custom-tailored rehabilitative exercise program prescribed by a physical therapist during a clinic visit. The patients were guided by the home telecare units in following their individualized exercise plan. After the patients used the physical telerehabilitation system for 12 weeks, a statistically significant improvement was shown in a timed 25-foot walk (from 13.8 +/-8.3 s to 11.3 +/-5.4 s), 6-minute walk (from 683.3 +/-463.8 ft to 806.5 +/-415.0 ft), and Berg Balance Scale score (from 38.8 +/-11.1 to 43.1 +/-9.9) as compared with the baseline. (Values are shown as mean +/standard deviation.) Patients were highly satisfied with the service. Home-based physical telerehabilitation can improve functional outcomes significantly in patients with MS. Abbreviations: BBS = Berg Balance Scale, CSQ-8 = Client Satisfaction Questionnaire (8 items), HAT = Home Automated Telemanagement, MAS = Modified Ashworth Scale, MMSE = Mini-Mental State Examination, MOS = Medical Outcomes Study, MS = multiple sclerosis, MSQOL-54 = MS QOL (54item scale), MSSE = MS Self-Efficacy Scale, MSWS-12 = 12-Item MS Walking Scale, PDDS = Patient-Determined Disease Steps, QOL = quality of life, T25FW = timed 25-foot walk, VA = Department of Veterans Affairs, VAMC = VA medical center.