Using tea nanoclusters as β-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia: A promising therapeutic strategy by Chinese materioherbology

Zhou, Ziao; Li, Jun; Tan, Lei; Zheng, Yufeng; Cui, Zhenduo; Li, Changyi; Yeung, Kelvin Wai Kwok; Li, Zhaoyang; Liang, Yanqin; Zhu, Shengli; Wu, Shuilin

doi:10.1016/j.fmre.2021.11.019

Cited by 12 publications

(7 citation statements)

References 47 publications

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“…First, surgically clearing dead infected tissue can damage bone integrity and possibly lead to disability. , In addition, ischemic conditions and the blood–bone barrier make it difficult for antibiotics to reach infected sites, and long-term antibiotic treatment can not only damage the body’s immune system and cause severe adverse reactions but also lead to the development of resistance mechanisms in S. aureus , thereby evading the attack from the body’s immune system and antibiotics. , Therefore, it is vital to seek other therapeutic ways to replace antibiotic therapy. Semiconductor nanomaterials have been widely studied on account of their chemical and physical properties; for example, some semiconductor nanomaterials have reactive oxygen species (ROS) or heat in exogenous stimuli, such as light, ultrasonic waves, and microwaves, that can kill bacteria while promoting cell growth and tissue repair through their special chemical or physical properties. ,,− Among these exogenous therapeutic strategies, phototherapy has the advantages of good controllability, high selectivity, highly effective antibacterial activity, and broad-spectrum antibacterial property; however, it is difficult for light to reach deep tissues because of its poor penetration ability, which limits the application of phototherapy in deep tissues. , …”

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confidence: 99%

Interfacial Mo, W-Conjugated Polarization, and Oxygen Vacancies of MoO₂/WO₃ in Enhanced Microwave Therapy for MRSA-Induced Osteomyelitis

Zhu

Liu

et al. 2022

ACS Nano

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Deep tissue infection, such as osteomyelitis, caused by methicillin-resistant Staphylococcus aureus (MRSA) infection, poses a serious threat to public health and cannot be effectively treated by antibiotics. In this study, we report a microwave (MW)-responsive MoO 2 /WO 3 heterojunction that can be utilized to effectively treat MRSA-infected osteomyelitis under MW irradiation because of the enhanced MW thermal effect and MW catalysis of the composite. The underlying mechanism is as follows: A myriad of oxygen vacancies forms on the surface of MoO 2 and WO 3 by deoxidization effect with hydrogen from the decomposition of sodium borohydride, which induces a mass of free electrons on the surface of the composite and consequently promotes a localized surface plasmon resonance effect (LSPR) under MW irradiation. Furthermore, the conjugation of Mo and W at the interface enhances the LSPR effect. Thus, the LSPR effect not only induces the formation of radical oxygen species, thereby enhancing MW catalysis, but also results in the formation of an interfacial electrical field, which strengthens dipole polarization through synergistic action with oxygen vacancies and contributes to better MW thermal effects. The characteristics of MoO 2 /WO 3 prove to be promising for the treatment of deep-tissue infections under MW irradiation.

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confidence: 99%

Interfacial Mo, W-Conjugated Polarization, and Oxygen Vacancies of MoO₂/WO₃ in Enhanced Microwave Therapy for MRSA-Induced Osteomyelitis

Zhu

Liu

et al. 2022

ACS Nano

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“…The outer membrane vesicles inherited partial membrane protein and can be used as antigens in consequence [ 39 , 40 ]. They can also activate immunoreaction of infected patients in vivo except for loaded drug [ 30 , 31 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammation and Microbiota Regulation Potentiate Pneumonia Therapy by Biomimetic Bacteria and Macrophage Membrane Nanosystem

Liu

Cui

et al. 2023

Research

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While conventional nanosystems can target infected lung tissue, they cannot achieve precise cellular targeting and enhanced therapy by modulating inflammation and microbiota for effective therapy. Here, we designed a nucleus-targeted nanosystem with adenosine triphosphate (ATP) and reactive oxygen species stimuli–response to treat pneumonia coinfected with bacteria and virus that is enhanced through inflammation and microbiota regulation. The nucleus-targeted biomimetic nanosystem was prepared through the combined bacteria–macrophage membrane and loaded hypericin and ATP-responsive dibenzyl oxalate (MMHP) subsequently. The MMHP despoiled the Mg 2+ of intracellular cytoplasm in bacteria to achieve an effective bactericidal performance. Meanwhile, MMHP can target the cell nucleus and inhibit the H1N1 virus duplication by inhibiting the activity of nucleoprotein. MMHP possessed an immunomodulatory ability to reduce the inflammatory response and activate CD8 + T cells for assisted infection elimination. During the mice model, the MMHP effectively treated pneumonia coinfected with Staphylococcus aureus and H1N1 virus. Meanwhile, MMHP mediated the composition of gut microbiota to enhance the pneumonia therapy. Therefore, the dual stimuli-responsive MMHP possessed promising clinical translational potential to therapy infectious pneumonia.

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“…However, the long-term and systemic safety of common commercial antimicrobial agents, such as metal nanoparticles, remains a major challenge [ 8 – 10 ]. Therefore, various innovative antibacterial strategies are developed to rapidly eradicate bacteria, including materioherbology, photocatalytic disinfection, and photothermal therapy [ 11 – 15 ]. Antibacterial materials that respond to external stimuli, especially light, have been widely studied for their rapid and reusable antibacterial effect, broad antibacterial spectrum, and non-antibiotic resistance.…”

Section: Introductionmentioning

confidence: 99%

Rapid Ferroelectric-Photoexcited Bacteria-Killing of Bi4Ti3O12/Ti3C2Tx Nanofiber Membranes

Wang

Qiao

et al. 2022

Adv. Fiber Mater.

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In this study, an antibacterial nanofiber membrane [polyvinylidene fluoride/Bi 4 Ti 3 O 12 /Ti 3 C 2 T x (PVDF/BTO/Ti 3 C 2 T x )] is fabricated using an electrostatic spinning process, in which the self-assembled BTO/Ti 3 C 2 T x heterojunction is incorporated into the PVDF matrix. Benefiting from the internal electric field induced by the spontaneously ferroelectric polarization of BTO, the photoexcited electrons and holes are driven to move in the opposite direction inside BTO, and the electrons are transferred to Ti 3 C 2 T x across the Schottky interface. Thus, directed charge separation and transfer are realized through the cooperation of the two components. The recombination of electron–hole pairs is maximumly inhibited, which notably improves the yield of reactive oxygen species by enhancing photocatalytic activity. Furthermore, the nanofiber membrane with an optimal doping ratio exhibits outstanding visible light absorption and photothermal conversion performance. Ultimately, photothermal effect and ferroelectric polarization enhanced photocatalysis endow the nanofiber membrane with the ability to kill 99.61% ± 0.28% Staphylococcus aureus and 99.71% ± 0.16% Escherichia coli under 20 min of light irradiation. This study brings new insights into the design of intelligent antibacterial textiles through a ferroelectric polarization strategy. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s42765-022-00234-8.

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Using tea nanoclusters as β-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia: A promising therapeutic strategy by Chinese materioherbology

Cited by 12 publications

References 47 publications

Interfacial Mo, W-Conjugated Polarization, and Oxygen Vacancies of MoO₂/WO₃ in Enhanced Microwave Therapy for MRSA-Induced Osteomyelitis

Interfacial Mo, W-Conjugated Polarization, and Oxygen Vacancies of MoO₂/WO₃ in Enhanced Microwave Therapy for MRSA-Induced Osteomyelitis

Inflammation and Microbiota Regulation Potentiate Pneumonia Therapy by Biomimetic Bacteria and Macrophage Membrane Nanosystem

Rapid Ferroelectric-Photoexcited Bacteria-Killing of Bi4Ti3O12/Ti3C2Tx Nanofiber Membranes

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Using tea nanoclusters as β-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia: A promising therapeutic strategy by Chinese materioherbology

Cited by 12 publications

References 47 publications

Interfacial Mo, W-Conjugated Polarization, and Oxygen Vacancies of MoO2/WO3 in Enhanced Microwave Therapy for MRSA-Induced Osteomyelitis

Interfacial Mo, W-Conjugated Polarization, and Oxygen Vacancies of MoO2/WO3 in Enhanced Microwave Therapy for MRSA-Induced Osteomyelitis

Inflammation and Microbiota Regulation Potentiate Pneumonia Therapy by Biomimetic Bacteria and Macrophage Membrane Nanosystem

Rapid Ferroelectric-Photoexcited Bacteria-Killing of Bi4Ti3O12/Ti3C2Tx Nanofiber Membranes

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Product

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Interfacial Mo, W-Conjugated Polarization, and Oxygen Vacancies of MoO₂/WO₃ in Enhanced Microwave Therapy for MRSA-Induced Osteomyelitis

Interfacial Mo, W-Conjugated Polarization, and Oxygen Vacancies of MoO₂/WO₃ in Enhanced Microwave Therapy for MRSA-Induced Osteomyelitis