Using systemic analgesics for managing ocular pain

Gurwood, Andrew S.; Pelino, Carlo J.

doi:10.1016/0953-4431(96)00152-x

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Cited by 3 publications

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“…reduced alertness, hallucinations, gastrointestinal, liver, and kidney toxicity). 33 In addition, when pain is limited to the ocular surface, there is no rationale for using systemic pain control if topical alternatives are available.…”

Section: Discussionmentioning

confidence: 99%

Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade

Vitar

Barbariga

Fonteyne

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade

Vitar

Barbariga

Fonteyne

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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The two-faced effects of nerves and neuropeptides in corneal diseases

Vitar

Rama

Ferrari

2022

Progress in Retinal and Eye Research

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Immunity and pain in the eye: focus on the ocular surface

Vitar

Bonelli

Rama

et al. 2021

Clinical and Experimental Immunology

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Most ocular diseases are associated with pain. While pain has been generally considered a mere (deleterious) additional symptom, it is now emerging that it is a key modulator of innate/adaptive immunity. Because the cornea receives the highest nerve density of the entire body, it is an ideal site to demonstrate interactions between pain and the immune response. Indeed, most neuropeptides involved in pain generation are also potent regulators of innate and adaptive leukocyte physiology. On the other hand, most inflammatory cells can modulate the generation of ocular pain through release of specific mediators (cytokines, chemokines, growth factors, lipid mediators). This review will discuss the reciprocal role(s) of ocular surface (and specifically: corneal) pain on the immune response of the eye. Finally, we will discuss clinical implications of such reciprocal interactions in the context of highly prevalent corneal diseases.

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Using systemic analgesics for managing ocular pain

Cited by 3 publications

References 11 publications

Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade

Modulating Ocular Surface Pain Through Neurokinin-1 Receptor Blockade

The two-faced effects of nerves and neuropeptides in corneal diseases

Immunity and pain in the eye: focus on the ocular surface

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