Using runs of homozygosity and machine learning to disentangle sources of inbreeding and infer self-fertilization rates
Leo Zeitler,
Kimberly J. Gilbert
Abstract:Runs of homozygosity (ROHs) are indicative of elevated homozygosity and inbreeding due to mating of closely related individuals. Self-fertilization can be a major source of inbreeding which elevates genomewide homozygosity and thus should also create long ROHs. While ROHs are frequently used to understand inbreeding in the context of conservation and selective breeding, as well as for consanguinity of populations and their demographic history, it remains unclear how ROH characteristics are altered by selfing a… Show more
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