Using rodents to model abnormal sensitivity to feedback in depression

Ryguła, Rafał; Noworyta-Sokołowska, Karolina; Drozd, Robert; Kozub, Anna

doi:10.1016/j.neubiorev.2018.10.008

Cited by 22 publications

(23 citation statements)

References 103 publications

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“…This interpretation is consistent with previous studies showing that pessimistic animals were more vulnerable to stressors [27,31]. For instance, stress-induced anhedonia was stronger and lasted longer in pessimistic rats [27] that were also found more sensitive to negative feedback [55]. The negative expectations of pessimistic individuals are likely to contribute to the experience of negative feelings after painful or stressful experiences and to play a role in the development and maintenance of depressive symptoms such as anhedonia [30].…”

Section: Plos Onesupporting

confidence: 91%

Pessimistic dairy calves are more vulnerable to pain-induced anhedonia

et al. 2020

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Pain induces deficits in appreciation of rewards (i.e. anhedonia) and variation in response to pain may be partly explained by individual differences in general expectations (i.e. optimism). Dairy calves are routinely subjected to painful procedures such as hot-iron disbudding. We tested if female Holstein calves (n = 17) display signs of anhedonia (as evidenced by reduced consumption of a sweet solution) after hot-iron disbudding (performed under general and local anesthesia), and whether individual differences in optimism explain the variation in this response. Individual variation in optimism was measured using responses to two judgment bias tests (performed when calves were 25 d old), and anhedonia was measured by comparing consumption of a sweet solution before and after hot-iron disbudding. We found that intake of the sweet solution declined (by mean ± SD: 48.4 ± 44.3%) on the day after disbudding, and that more pessimistic calves were more affected. Sweet solution consumption did not return to baseline for the duration of the study (i.e. 5 days). Calves reduced their intake of a sweet solution after hot-iron disbudding, consistent with pain-induced anhedonia, and more pessimistic calves showed stronger evidence of anhedonia, suggesting that they were more affected by the procedure. However, our results cannot rule out the possibility that calf responses were driven by anorexia.

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Section: Plos Onesupporting

confidence: 91%

Pessimistic dairy calves are more vulnerable to pain-induced anhedonia

et al. 2020

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“…What happens when this selection of actions goes awry? Cognitive distortions may result when integration of positive and negative events are devalued (8). Therefore, it is important to understand how the brain neural circuitry confronts the values of upcoming and previous actions (9).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is important to understand how the brain neural circuitry confronts the values of upcoming and previous actions (9). Growing evidence indicates that abnormal feedback sensitivity between various corticostriatal loops and the reward system could be associated with the occurrence of depressive episodes (8).…”

Section: Introductionmentioning

confidence: 99%

Bridging the Gap between Brain-Derived Neurotrophic Factor and Glucocorticoid Effects on Brain Networks

et al. 2018

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Behavioral choices made by the brain during stress depend on glucocorticoid and BDNF signaling pathways acting in synchrony in the mesolimbic (reward) and corticolimbic (emotion) neural networks. Deregulated expression of BDNF and glucocorticoid receptors in brain valuation areas may compromise integration of signals. Glucocorticoid receptor phosphorylation upon BDNF signaling in neurons represents one mechanism underlying the integration of BDNF and glucocorticoid signals that when off balance may lay the foundation of maladaptations to stress.Here, we propose that BDNF signaling conditions glucocorticoid responses impacting neural plasticity in the mesocorticolimbic system. This provides a novel molecular framework for understanding how brain networks use BDNF and glucocorticoid signaling contingencies to forge receptive neuronal fields in temporal domains defined by behavioral experience, and in mood disorders. Introduction Cooperation between the mesolimbic and corticolimbic systems determines behavioral choicesBrain region-specific effects of BDNF and glucocorticoids on the mesocorticolimbic system Bridging the gaps between BDNF and glucocorticoid effects in the mesocorticolimbic system GR phosphorylation is influenced by BDNF signaling Effect of BDNF and glucocorticoid signaling in health and disease Summary References

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“…Over the past years, behavioral research has revealed that a concept of cognitive/behavioral traits exists and can be measured in animals (Gosling, 2001 ). It also revealed that there exists considerable cross-species overlap for some of these traits and that the assessment of these traits in animals has numerous practical applications that can contribute to a better understanding of psychiatric disorders (Rygula et al, 2018 ). For instance, recent studies using animal models have demonstrated that trait “pessimism,” which has been previously linked with increased sensitivity to NF (Rygula and Popik, 2016 ), is associated with a “pro-depressive profile” that predicts increased vulnerability to stress-induced anhedonia (Rygula et al, 2013 ) and motivational deficits (Drozd et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Trait Sensitivity to Negative and Positive Feedback Does Not Interact With the Effects of Acute Antidepressant Treatment on Hedonic Status in Rats

Surówka

Noworyta-Sokołowska

Ryguła

2020

Front. Behav. Neurosci.

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Aberrant cognition plays a pivotal role in the development and maintenance of depression. One of the most important cognitive distortions associated with depression is aberrant sensitivity to performance feedback. Under clinical conditions, this sensitivity can be measured using the probabilistic reversal learning (PRL) test, which has also been recently implemented in animal studies. Although the evidence for the coexistence of depression and altered feedback sensitivity is relatively coherent, it is unclear whether this sensitivity can influence the effectiveness of antidepressant treatment. In the present research, we investigated how trait sensitivity to negative and positive feedback interacts with the effects of acute antidepressant treatment on hedonic status in rats. We tested a cohort of rats with a series of 10 PRL tests, and based on this screening, we classified each animal as sensitive or insensitive to negative and positive feedback. Subsequently, in the Latin square design, we evaluated the effects of a single administration of two antidepressant drugs (each at three different doses: agomelatine: 5, 10, and 40 mg/kg; mirtazapine 0.5, 1, and 3 mg/kg) on the hedonic status of rats in the sucrose preference tests. There was no statistically significant interaction between trait sensitivity to feedback and the effects of acute antidepressant treatment on hedonic status in rats.

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Using rodents to model abnormal sensitivity to feedback in depression

Cited by 22 publications

References 103 publications

Pessimistic dairy calves are more vulnerable to pain-induced anhedonia

Pessimistic dairy calves are more vulnerable to pain-induced anhedonia

Bridging the Gap between Brain-Derived Neurotrophic Factor and Glucocorticoid Effects on Brain Networks

Trait Sensitivity to Negative and Positive Feedback Does Not Interact With the Effects of Acute Antidepressant Treatment on Hedonic Status in Rats

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