Using PVC ion-selective electrodes for the potentiometric flow injection analysis of distigmine in its pharmaceutical formulation and biological fluids

Issa, Y. M.; Khorshid, Amal Fouad

doi:10.1016/j.jare.2010.08.007

Cited by 18 publications

(11 citation statements)

References 44 publications

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“…The influence of the ion-associating reagent in the preparation of the complex, which is the major component of a membrane for an ISE, was investigated. PTA and PMA are two ion-associate reagents used to prepare ion-pair complex with drugs containing nitrogenous basic group (Ezzeldin et al, 2012;Issa and Khorshid, 2011;Hefnawy et al, 2014;Shawish et al, 2018;Al-Mohaimeed et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

Rajendraprasad

Basavaiah

2019

J Anal Sci Technol

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Background: Lisinopril (LNP) is an angiotensin-converting enzyme inhibitor used as anti-hypertensive, cardiovascular, in anti-prophylactic and anti-diabetic nephropathy drug. Development of two new, simple, low cost, and selective membrane-based ion-selective electrodes has been proposed for the determination of LNP in pharmaceuticals. Methods: The electrodes are based on poly(vinyl)chloride membrane doped with LNP-phosphotungstic acid (LNP-PTA) and LNP-phosphomolybdic acid (LNP-PMA) ion-pairs as molecular recognition materials. Results: The developed LNP-PTA and LNP-PMA electrodes are applicable for the determination of LNP over the linear range of 5 × 10 −5 -2.4 × 10 −3 mol l −1 . The working pH ranges to measure potentials were 2.5 to 6.4 and 2.3 to 6.0 for LNP-PTA and LNP-PMA ISEs, respectively. The electrodes displayed the rapid Nernstian responses as revealed by the values of slopes 55.06 and 52.39 mV/decade, with limit of detection (LOD) values of 1.2 × 10 −5 and 1.18 × 10 −5 mol l −1 for LNP-PTA and LNP-PMA electrodes, respectively. The limits of quantitation (LOQ) values have also been calculated for both the electrodes. The developed electrodes have potential stability for up to 1 month and emerged as highly selective for the determination of LNP over other spiked ions and compounds. Conclusions: The proposed electrodes have been validated and found that they are suitable for the determination of LNP in pharmaceuticals in pure form and in dosage forms. The results obtained in the analysis of LNP using proposed electrodes have been compared statistically with reference method's results to assess the accuracy and precision. Robustness and ruggedness of the developed electrodes have also been checked and found satisfactory. The recovery studies have been performed by standard addition procedure to assess the role of excipients in tablets containing LNP and the results obtained are satisfactory.

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Section: Resultsmentioning

confidence: 99%

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

Rajendraprasad

Basavaiah

2019

J Anal Sci Technol

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“…A small thermal coefficient value indicates high thermal stability of the corresponding potentiometric sensor. Temperature coefficients

{(d {normalE}^{^{\circ}} / dt)}_{cell}

and

{(d {normalE}^{^{\circ}} / dt)}_{sen}

were determined from Figure S2 which was plotted using equation (2) , and found to be 0.087 and 0.783 mV/°C for

{(d {normalE}^{^{\circ}} / dt)}_{cell}

and

{(d {normalE}^{^{\circ}} / dt)}_{sen}

, respectively. It is obvious from the low values of the thermal coefficients that the sensor is thermally stable over a wide temperature range.

true {normalE}^{^{\circ}} = E_{25 normalC^{\circ}}^{^{\circ}} + ({dE}^{^{\circ}} / dt) (normalt - 25)

…”

Section: Resultsmentioning

confidence: 99%

“…TCH can be estimated using different spectrophotometric and chromatographic methods. Although spectrophotometric methods are simple, affordable and have reasonable accuracy, their limits of detection (LOD) are not very low; so that very dilute concentrations cannot be estimated.…”

Section: Introductionmentioning

confidence: 99%

A Disposable Homemade Screen Printed Electrochemical Sensor for Vitamin B1 Determination in Multivitamin Ampoules: Potentiometric and Surface Morphology Studies

2017

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Thiamine chloride hydrochloride (TCH) is one of the B‐complex vitamins which resemble a very biologically important group of biomolecules. The first screen‐printed graphite ion‐selective sensor for the determination of TCH was prepared and characterized. The sensor is based on TCH‐tetraphenylborate as electrode material. A number of parameters such as the type of solvent mediator, weight percent of the ion‐exchanger, test solution temperature and possible interferences were extensively studied. Moreover, the surface morphology of the prepared sensor was studied using scanning electron microscopy. The sensor shows a Nernstian slope of 30.60±0.07 mV/decade, a low LOD of 5.08×10−6 mol/L and a wide applicability range of 5.96×10−6‐1.00×10−2 mol/L. The sensing graphite ink remains usable for at least one month. Fast potentiometric response was obtained within 5 s and remains stable for at least 60 s. The sensor was applied to the analysis of TCH in pure solutions and multivitamin ampoules from the Egyptian market using the standard addition method and high recovery values of 97–102 % were obtained. Low %RSD values (0.27‐1.30) indicate high precision of the proposed sensor. Our sensor provides the advantages of disposability, simple preparation procedures, sensitivity and easy storage and transportation.

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“…Removal of basic dyes: The capability of the minimal effort adsorbent Azadirechta indica leaves (Neem) to remove methylene blue from fluid arrangement was examined at room temperature [120]. Ideal condition for investigation was measured at pH (3)(4)(5)(6)(7)(8)(9)(10)(11), adsorbent measurement (1-12 g/L), contact time (15-240 min). The outcomes shows an extraordinary adsorption limit of methylene blue colour by neem leaves and propose another conceivable utilization of this adsorbent material in removal of dyes from aqueous solution.…”

Section: Removal Of Dyesmentioning

confidence: 99%

“…These innovations are very costly, not earth agreeable and generally subject to one of convergence of waste [5]. Therefore, the quest for productive, eco welldisposed and practical solutions for wastewater treatment has been initiated [6].…”

Section: Introductionmentioning

confidence: 99%

Study of Biosorbents for Removal of Dyes and Metals

Gaur¹,

Sharma²

2017

Asian J. Chem.

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Using PVC ion-selective electrodes for the potentiometric flow injection analysis of distigmine in its pharmaceutical formulation and biological fluids

Cited by 18 publications

References 44 publications

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

A Disposable Homemade Screen Printed Electrochemical Sensor for Vitamin B1 Determination in Multivitamin Ampoules: Potentiometric and Surface Morphology Studies

Study of Biosorbents for Removal of Dyes and Metals

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