Using Patient-Level Data to Develop Meaningful Cross-Trial Comparisons of Visual Impairment in Individuals with Diabetic Macular Edema

Sivaprasad, Sobha; Régnier, Stephane A.; Fajnkuchen, Franck; Wright, Jonathan; Berger, Alan R.; Mitchell, Paul; Larsen, Michael

doi:10.1007/s12325-016-0310-0

Cited by 2 publications

(1 citation statement)

References 18 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We used two different anti-VEGFs, ranibizumab and aflibercept. Available data suggest that these two drugs are mostly similar [ 6 , 22 ]. According to the multivariate linear regression model, there was no difference between the two anti-VEGFs (Table 3 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of markers of outcome in real-world treatment of diabetic macular edema

Campos

Carmo

et al. 2018

Eye and Vis

View full text Add to dashboard Cite

ObjectiveTo evaluate short-term markers of outcome in diabetic macular edema (DME).MethodsProspective interventional case series included 122 eyes of 122 patients with recently diagnosed DME. Eyes were treated with a 3-monthly loading dose of ranibizumab or aflibercept and pro re nata thereafter. Serial enhanced deep imaging SD-OCT high resolution scans were used to measure subfoveal choroidal thickness (SFCT) and central retinal thickness (CRT). Anatomic (10% CRT decrease) and functional responses (best corrected visual acuity, BCVA gain ≥5 letters) were assessed at 3 months and 6 months using univariate and multivariate analyses. Parameters tested were gender, duration of diabetes, HbA1c, hypertension, CRT, SFCT, BCVA, ellipsoid zone (EZ) status, subfoveal neuroretinal detachment (SND), anti-VEGF used and laser naivety. A logistic regression model was applied to find independent markers outcome.ResultsBCVA increased, CRT and SFCT decreased at 3 months and 6 months. Good metabolic control (p = 0.003), intact baseline EZ (p = 0.030), EZ re-grading at 3 M (p < 0.001) and laser naivety (p = 0.001) were associated with better functional outcome. The multivariate linear regression model showed that baseline SND and CRT are predictors of anatomic response, while lower baseline BCVA and intact EZ are predictors of functional response.ConclusionThe presence of SND predicts anatomic response only, while an intact EZ is critical to achieve a good functional outcome in DME.Electronic supplementary materialThe online version of this article (10.1186/s40662-018-0119-9) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%