Using optical coherence tomography to evaluate skin sun damage and precancer

Korde, Vrushali; Bonnema, Garret T.; Xu, Wei; Krishnamurthy, C.; Ranger‐Moore, James; Saboda, Kathylynn; Slayton, Lisa D.; Salasche, Stuart J.; Warneke, James; Alberts, David S.; Barton, Jennifer K.

doi:10.1002/lsm.20573

Cited by 121 publications

(106 citation statements)

References 15 publications

(22 reference statements)

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“…[9][10][11][12][13][14] A number of clinical studies have suggested that OCT might be useful for noninvasive diagnosis of skin disorders such as inflammatory and bullous skin diseases and to assess wound healing. 15,16 Several reports to date have examined the use of OCT imaging of NMSC. Previous studies demonstrate OCT images of BCC, SCC, and actinic keratoses (AK) and have correlated these findings with standard histology.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

et al. 2012

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Abstract. We investigate morphological differences in three-dimensional (3-D) images with cellular resolution between nonmelanoma skin cancer and normal skin using Gabor domain optical coherence microscopy. As a result, we show for the first time cellular optical coherence images of 3-D features differentiating cancerous skin from normal skin. In addition, in vivo volumetric images of normal skin from different anatomic locations are shown and compared.

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Section: Introductionmentioning

confidence: 99%

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

et al. 2012

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“…Therefore, the feasibility of machine learning tools was investigated in several studies [215,216]. Higher diagnostic accuracy compared to human observers could be achieved in some cases, demonstrating the potential as well as the need for improvement of these methods.…”

Section: Dermatologymentioning

confidence: 99%

Optical coherence tomography—current technology and applications in clinical and biomedical research

et al. 2011

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Optical coherence tomography (OCT) is a non-invasive imaging technique providing real-time twoand three-dimensional images of scattering samples with micrometer resolution. Mapping the local reflectivity, OCT visualizes the morphology of the sample. In addition, functional properties such as birefringence, motion or the distribution of certain substances can be detected with high spatial resolution. The main field of application is bio-medical imaging and diagnostics. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring treatment of a number of retinal diseases, and OCT is becoming an important instrument for clinical cardiology. New applications are emerging in various medical fields, e. g. early-stage cancer detection, surgical guidance, and early diagnosis of musculoskeletal diseases. OCT has also proven its value as a tool for developmental biology. The number of companies involved in manufacturing OCT systems has increased substantially during the last years-especially due to its success in opthalmology-and this technology can be expected to continue to spread into various fields of application.

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“…Because the scattering properties do not change significantly for different wavelengths, this information could still be very interesting for obtaining information as correct as possible regarding the skin optical properties. OCT and confocal laser scanning microscopy have, for instance, been used to measure the thickness of stratum corneum and epidermis [136] as well as photodamage caused by Sun exposure [137]. Although OCT usually uses near infrared radiation in order to get depth sensitivity, it should be able to assess the relative strength of scattering in different skin layers.…”

Section: Instrumentations and Techniques To Measure Light Transmissiomentioning

confidence: 99%

Solar radiation and human health

Moan

Juzeniene

2010

Journal of Photochemistry and Photobiology B: Biology

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The Sun has played a major role in the development of life on Earth. In Western culture, people are warned against Sun exposure because of its adverse effects: erythema, photoimmunosuppression, photoageing, photocarcinogenesis, cataracts and photokeratitis. However, Sun exposure is also beneficial, since moderate doses give beneficial physiological effects: vitamin D synthesis, reduction of blood pressure and mental health. Shortage of Sun exposure may be even more dangerous to human health than excessive exposure. Avoiding Sun exposure leads to vitamin D deficiency which is associated not only with rickets and osteomalacia, but also with increased risk of cardiovascular disease, multiple sclerosis, rheumatoid arthritis, diabetes, influenza, many types of cancer and adverse pregnancy outcomes. Solar radiation induces nitric oxide release in tissue and immediate pigment darkening which certainly play important roles, although these are still unknown. Action spectra relevant for health are described. We will also review what is known about spectral and intensity variations of terrestrial solar radiation as well as its penetration through the atmosphere and into human skin and tissue.

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Using optical coherence tomography to evaluate skin sun damage and precancer

Abstract: Background and Objectives-Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK).

Cited by 121 publications

References 15 publications

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

Optical coherence tomography—current technology and applications in clinical and biomedical research

Solar radiation and human health

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