Using of Amniotic Membrane Derivatives for the Treatment of Chronic Wounds

Abstract

Amniotic membrane grafts have some therapeutic potential for wounds healing. Early application of amniotic membrane turned out as beneficial in healing ulcers, burns, and dermal injuries. Since the second half of the 20th century, the autotransplants of amniotic/chorion tissue have been also used for the treatment of chronic neuropathic wounds, cornea surface injuries, pterygium and conjunctivochalasis, and dental and neurosurgical applications. The aim of this publication is to prepare a coherent overview of amniotic membrane derivatives use in the field of wound healing and also its efficacy. In total 60 publications and 39 posters from 2000–2020 were examined. In these examined publications of case studies with known study results was an assemblage of 1141 patients, and from this assemblage 977 were successfully cured. In case of posters, the assemblage is 570 patients and 513 successfully cured. From the investigated data it is clear that the treatment efficacy is very high—86% and 90%, respectively. Based on this information the use of the amniotic membrane for chronic wounds can be considered highly effective.

Innovative Cell and Platelet Rich Plasma Therapies for Diabetic Foot Ulcer Treatment: The Allogeneic Approach

“…Among allogeneic approaches for diabetic foot ulcers, it has to be mentioned the amniotic membrane. This natural dressing is being used for decades to promote tissue regeneration and in skin repair as it releases factors promoting cell function, it is non-immunogenic, reduces pain, inflammation and fibrosis, among other properties ( Schmiedova et al, 2021 ). Amniotic membranes have been widely tested in clinical settings and proved to significantly promote healing of recalcitrant DFU in combination with standard care approaches ( Laurent et al, 2017 ).…”

Protecting human amnion and chorion matrices during processing: Performance enhancement in a diabetic mouse model and human co‐culture system

“…Processed human amnion and chorion membranes (HACM) in cryopreserved, dehydrated or acellular forms have been considered as an adjunctive wound therapy and proven to promote both acute and chronic wound healing outcomes in patients with venous leg ulcers (VLU) and diabetic foot ulcers (DFU) 4,5 . HACM contains important growth factors, cytokines, and extracellular matrix (ECM) components that are known to play critical roles in physiological wound healing processes such as modulation of inflammation and promoting tissue regenerative responses, such as cell proliferation and angiogenesis, which can enhance healing of impaired wounds 6,7 . HACM also has a preponderance of exosomes and endosomes, which contain intrinsic signalling components (including proteins and nucleic acids), to critical to the wound repair and regeneration process 8 .…”

“…4,5 HACM contains important growth factors, cytokines, and extracellular matrix (ECM) components that are known to play critical roles in physiological wound healing processes such as modulation of inflammation and promoting tissue regenerative responses, such as cell proliferation and angiogenesis, which can enhance healing of impaired wounds. 6,7 HACM also has a preponderance of exosomes and endosomes, which contain intrinsic signalling components (including proteins and nucleic acids), to critical to the wound repair and regeneration process. 8 Much of the improved healing with HACM in clinical studies has resulted from advances in processing of these tissues to better preserve and to protect the important growth factors and signalling molecules in these matrices.…”

Effect of amniotic membrane and platelet‐rich fibrin membrane on bone healing post endodontic surgery: An ultrasonographic, randomized controlled study

“…One such biologically/naturally derived tissue is the Human amniotic membrane (hAM) which has been utilized in the medical field since 1900 when Dr. Nicholas Sabella first reported a clinical case of burns managed by hAM. Since then, most medical areas like ophthalmology, otolaryngology, and plastic surgery have utilized hAM in their treatment protocols (Fairbairn et al., 2014; Fernandes et al., 2005; Gomes et al., 2005; S Hsu, 2014; Schmiedova et al., 2021). The use of hAM in dental fields is relatively new (Gheisari et al., 2017; A. Sharma & Yadav, 2015; M. Sharma et al., 2017 Fénelon et al., 2018).…”