Using non-invasive transcranial stimulation to improve motor and cognitive function in Parkinson’s disease: a systematic review and meta-analysis

Goodwill, Alicia M.; Lum, Jarrad A. G.; Hendy, Ashlee M.; Muthalib, Makii; Johnson, Liam; Albein‐Urios, Natalia; Teo, Wei‐Peng

doi:10.1038/s41598-017-13260-z

Cited by 60 publications

(48 citation statements)

References 87 publications

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“…In 2017, Lawrence et al [25] performed a detailed analysis of rTMS on different cognitive domains of PD patients with three included studies, which reported a negative outcomees. Another meta-analysis that conducted by Goodwill et al [26] with five articles also didn't found any significant effect for stimulation parameters on cognitive function. Although quantitative analysis was performed in these two studies, there is no further subgroup analysis for different rTMS parameters.…”

Section: Introductionmentioning

confidence: 91%

Effect of rTMS on Parkinson’s cognitive function: a systematic review and meta-analysis

Jiang

McClure

et al. 2020

BMC Neurol

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Background To evaluate the effects and optimal parameters of repetitive transcranial magnetic stimulation (rTMS) on cognition function of patients with Parkinson’s disease (PD) and to estimate which cognitive function may obtain more benefits from rTMS. Method The articles dealing with rTMS on cognitive function of PD patients were retrieved from the databases until April 2019. Outcomes of global cognitive function and different cognitive domains were extracted. The standardized mean differences (SMDs) with 95% confidence interval (CI) of cognitive outcome for different parameters, scales, and cognitive functions were estimated. Results Fourteen studies involving 173 subjects were included in this meta-analysis. A significant effect size was observed with the mini-mental state examination (MMSE) for the global cognitive outcome based on the evidence of four published articles. Further subtests for different cognitive domains demonstrated prominent effect for the executive function. The significant effect sizes for executive function were found with multiple sessions of high-frequency rTMS over frontal cortex; especially over dorsolateral prefrontal cortex (DLPFC). All of the other cognitive domains, which included memory, attention, and language ability, did not obtain significant effects. Conclusions Multiple sessions of high-frequency rTMS over the DLPFC may have positive effect on executive function in PD patients. Further well designed studies with large sample sizes are needed to verify our results and ascertain the long-term effects of rTMS.

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Section: Introductionmentioning

confidence: 91%

Effect of rTMS on Parkinson’s cognitive function: a systematic review and meta-analysis

Jiang

McClure

et al. 2020

BMC Neurol

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“…Several studies used tDCS as a single or adjuvant intervention in Parkinson rehabilitation (for reviews see Broeder et al, 2015;Elsner, Kugler, Pohl, & Mehrholz, 2016;Ferrucci, Mameli, Ruggiero, & Priori, 2016;Goodwill et al, 2017;Tahtis & Kaski, 2017). Improvements in upper limb performance of PD patients were found after anodal tDCS compared to sham when stimulation was applied to the primary motor cortex (M1) in rest (Benninger et al, 2010;Cosentino et al, 2017;Fregni et al, 2006) as well as during task performance (Salimpour, Mari, & Shadmehr, 2015).…”

Section: Introductionmentioning

confidence: 99%

Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson’s disease? A pilot study

Broeder

Heremans

Pereira

et al. 2019

Human Movement Science

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Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can boost motor performance in Parkinson's disease (PD) when it is applied at rest. However, the potential supplementary therapeutic effect of the concurrent application of tDCS during the training of motor tasks is largely unknown. The present study examined the effects of tDCS on upper limb motor blocks during a freezing-provoking writing task (the funnel task) requiring up- and down-stroke movements at alternating amplitudes. Ten PD patients and 10 age-matched controls underwent two sessions of writing combined with 20 min of anodal or sham tDCS on the left M1 in a randomized cross-over design. The primary outcome was the number of upper limb freezing episodes during five trials of the funnel task on a touch-sensitive tablet. PD patients showed a significant reduction in freezing episodes during tDCS compared to sham. No effects of tDCS were found for the amplitude, variability and speed of the strokes outside the freezing episodes. However, patients who reported freezing episodes in daily life (N = 6) showed a beneficial effect of tDCS on stroke characteristics. These results indicate a subgroup-dependent variability in response to non-invasive brain stimulation applied during the performance of motor tasks in PD. This warrants future studies to examine tDCS as an adjuvant tool for training programs aimed to reduce motor deficits related to freezing.

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“…[ 62 63 ] In PD patients, rTMS improved motor deficits (considering both UPDRS-III scores and gait parameters). [ 64 ] One recent case report of a narcolepsy patient who received 25 sessions of high-frequency rTMS over the left dorsolateral prefrontal cortex demonstrated that rTMS might be a safe and effective alternative strategy for treating narcolepsy-like symptoms. [ 65 ] Efficacy conclusion for TMS is under investigation.…”

Section: Anagement Of E Xcessive mentioning

confidence: 99%

Excessive Daytime Sleepiness in Parkinson's Disease

Shen

Huang

et al. 2018

Chinese Medical Journal

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Objective:Excessive daytime sleepiness (EDS) is one of the most common sleep abnormalities in patients with Parkinson's disease (PD), yet its multifactorial etiology complicates its treatment. This review summarized recent studies on the epidemiology, etiology, clinical implications, associated features, and evaluation of EDS in PD. The efficacy of pharmacologic and non-pharmacologic treatments for EDS in PD was also reviewed.Data Sources:English language articles indexed in PubMed and Cochrane databases and Chinese-language papers indexed in Wanfang and National Knowledge Infrastructure databases that were published between January 1987 and November 2017 were located using the following search terms: “sleepiness”, “sleep and Parkinson's disease”, and “Parkinson's disease and treatment”.Study Selection:Original research articles and critical reviews related to EDS in PD were selected.Results:EDS is a major health hazard and is associated with many motor and nonmotor symptoms of PD. Its causes are multifactorial. There are few specific guidelines for the treatment of EDS in PD. It is first necessary to identify and treat any possible factors causing EDS. Recent studies showed that some nonpharmacologic (i.e., cognitive behavioral therapy, light therapy, and repetitive transcranial magnetic stimulation) and pharmacologic (i.e., modafinil, methylphenidate, caffeine, istradefylline, sodium oxybate, and atomoxetine) treatments may be effective in treating EDS in PD.Conclusions:EDS is common in the PD population and can have an immensely negative impact on quality of life. Its causes are multifactorial, which complicates its treatment. Further investigations are required to determine the safety and efficacy of potential therapies and to develop novel treatment approaches for EDS in PD.

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Using non-invasive transcranial stimulation to improve motor and cognitive function in Parkinson’s disease: a systematic review and meta-analysis

Cited by 60 publications

References 87 publications

Effect of rTMS on Parkinson’s cognitive function: a systematic review and meta-analysis

Effect of rTMS on Parkinson’s cognitive function: a systematic review and meta-analysis

Does transcranial direct current stimulation during writing alleviate upper limb freezing in people with Parkinson’s disease? A pilot study

Excessive Daytime Sleepiness in Parkinson's Disease

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