Using nickel to fold discrete synthetic macromolecules into single-chain nanoparticles

Abstract

Macromolecules found in Nature display a precise control over the primary as well as higher ordered architectures. To mimic the folding found in Nature, we herein demonstrate the design and...

Sequence-Defined Mikto-Arm Star-Shaped Macromolecules

“…First, the synthesis of an A4-type star-shaped SDM was carried out (Scheme ). For this purpose, a pentamer of methyl acrylate (MA) was grown on a robotic peptide synthesizer with earlier optimized conditions using a TLa-bound Rink amide resin . At this point, we chose to introduce branching to the SDM via the use of multiple hydroxy groups.…”

“…The synthetic routes had to be carefully planned as the dual modification of the SDM required (i) to be compatible with the reagents used in other steps, (ii) orthogonality of the branching compounds, and (iii) high purity after each synthetic step. While several dual modification methods exist, − a thiolactone-based dual modification strategy was selected as a result of its well-known high reaction yields and the option to use a wide range of monomers. − …”

“…The robustness and versatility of this proposed chemistry platform (A in Scheme ) were already demonstrated for numerous applications, including macromolecular data storage, − and the protocols can be readily automated using a standard peptide synthesizer. , Therefore, this concept can in principle also be translated to the peptide and peptoid synthesis and could be used in various biological applications such as drug delivery and lecting binding, where multiple different functional groups are required …”

Thiolactone chemistry, a versatile platform for macromolecular engineering

“…It is also worth noting that various thiolactone-based synthetic approaches toward sequence-defined polymers have been recently developed. 159…”

“…It is also worth noting that various thiolactone-based synthetic approaches toward sequence-defined polymers have been recently developed. 159 The demand for "greener" materials is definitely growing in the society: macromolecular science is required to create environmental-friendly monomers and polymers via sustainable pathways. Thiolactone chemistry present many advantages to address this challenge.…”