Using multiple Process Analytical Technology probes to monitor multivitamin blends in a tableting feed frame

Durão, Pedro; Fauteux‐Lefebvre, Clémence; Guay, Jean-Maxime; Abatzoglou, Nicolas; Gosselin, Ryan

doi:10.1016/j.talanta.2016.11.013

Cited by 43 publications

(12 citation statements)

References 24 publications

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“…Moreover, Gosselin et al used PAT tools, such as light-induced fluorescence spectroscopy, NIRS, and color (RGB) imaging, to monitor the composition of powder flowing in the tableting process to determine the content of components. As shown in Figure 5 , the three probes could be used to monitor powder flowing in real time and are suitable for detecting undesirable phenomena, including the feed-frame dynamics and separation [ 277 ].…”

Section: Application Of Pat Framework For Control Strategy Of the Unit Operationsmentioning

confidence: 99%

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Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification

Kim

et al. 2021

Pharmaceutics

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Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry. The methods recognize that an appropriate combination of process controls and predefined material attributes and intermediate quality attributes (IQAs) during processing may provide greater assurance of product quality than end-product testing. The efficient analysis method to monitor the relationship between process and quality should be used. Process analytical technology (PAT) was introduced to analyze IQAs during the process of establishing regulatory specifications and facilitating continuous manufacturing improvement. Although PAT was introduced in the pharmaceutical industry in the early 21st century, new PAT tools have been introduced during the last 20 years. In this review, we present the recent pharmaceutical PAT tools and their application in pharmaceutical unit operations. Based on unit operations, the significant IQAs monitored by PAT are presented to establish a control strategy for CPV and real time release testing (RTRT). In addition, the equipment type used in unit operation, PAT tools, multivariate statistical tools, and mathematical preprocessing are introduced, along with relevant literature. This review suggests that various PAT tools are rapidly advancing, and various IQAs are efficiently and precisely monitored in the pharmaceutical industry. Therefore, PAT could be a fundamental tool for the present QbD and CPV to improve drug product quality.

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Section: Application Of Pat Framework For Control Strategy Of the Unit Operationsmentioning

confidence: 99%

“… Schematic of the position of three process analytical technology (PAT) tools on the tablet-press feed-frame for monitoring experimental samples [ 277 ]. Reproduced with permission from Pedro Durão, Talanta; published by Elsevier, 2017.…”

Section: Figurementioning

confidence: 99%

Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification

Kim

et al. 2021

Pharmaceutics

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“…Durao et al [128] studied the concentrations of 5 different constituents in a 31 component multivitamin powder blend in real-time as the blend was fed to a tableting press. Guay et al [129] monitored blending of pharmaceutical components in a V-blender using a non-contact probe that was affixed to one of the lids of the V-blender.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Review of noninvasive methods to characterize granular mixing

Nadeem

Heindel

2018

Powder Technology

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Granular mixing is a common process observed in a variety of industries such as construction, chemical processing, food handling, and cosmetics and pharmaceutical manufacturing. Over the years several methods have been devised to characterize granular mixing and to provide information on the quality of the mixture as well as mixing end points. In this work, three different noninvasive measurement categories are reviewed, namely: velocimetric, spectroscopic, and tomographic techniques. Velocimetric techniques such as Particle Image Velocimetry (PIV) and Radioactive particle tracking (RPT) are able to provide the trajectories and velocities of individual particles during the mixing process. Spectroscopic techniques focus on the chemical composition of the sample and are well suited for applications where there is little difference in the physical properties of the constituents such as particle size and density. Tomographic techniques such as X-ray computed tomography (CT) and Magnetic Resonance Imaging (MRI) provide information such as the spatial distribution of the different constituents in the sample and are useful in determining dead zones and inhomogeneities. A few other techniques are also discussed, particularly passive acoustic methods which, though can neither provide spatial distribution nor individual particle trajectories, are still useful and can be employed to determine mixing end points. The objective of the work is to provide a comparative assessment of the various noninvasive techniques and discuss their ability to effectively characterize the mixing process. The reported techniques will be reviewed thoroughly based on their functionality, viability, and characterization capability. The advantages and disadvantages of the various techniques are summarized and a comparison of the utility of the techniques in various applications is discussed.

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“…A similar methodology was also used by Karumanchi et al [27] for determining the dead zones in the mixer during powder mixing. Meanwhile, Durao et al [28] determined in this way the concentration of five different substances in a multicomponent vitamin preparation. The phenomenon of X-ray fluorescence (XRF) was used, among others, in the assessment of sulphur and chlorine content in feeds for ruminants.…”

Section: Introductionmentioning

confidence: 99%

Ultraviolet Fluorescence in the Assessment of Quality in the Mixing of Granular Material

Matuszek

2020

Sustainability

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The aim of the study was to determine the possibility of using ultraviolet fluorescence to evaluate the quality of the mixing process of industrial feed. A laboratory funnel-flow mixer was used for the mixing process. The studies were carried out using three different feeds for pigs. A key component in the form of ground grains of yellow maize covered with the fluorescent substance Rhodamine B was introduced into the mixer before the mixing process began. After the illumination of the sample by UV lamps, the images were taken with a digital camera. The images were analyzed in Patan ® software. The information obtained on the percentage content of the key component was used for further calculations. At the same time, the tracer content was determined using the control method (weight method). The comparison of the results obtained by the two methods (statistical comparative analysis) did not indicate significant differences. Therefore, the usefulness of the proposed method to track the share of the key component by inducing it to glow in the ultraviolet light has been proven. The introduced tracer is also one of the components of the feed, which translates into the possibility of observing the material having the characteristics of a mixed material.

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Using multiple Process Analytical Technology probes to monitor multivitamin blends in a tableting feed frame

Cited by 43 publications

References 24 publications

Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification

Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification

Review of noninvasive methods to characterize granular mixing

Ultraviolet Fluorescence in the Assessment of Quality in the Mixing of Granular Material

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