ABSTRACT. The purpose of this study was to evaluate three-dimensional images of liver tumours obtained with gadolinium ethoxybenzyl diethylenetriamine penta-acetic acid (Gd-EOB-DTPA)-enhanced MRI (3D-EOB-MRI) in hepatic surgery. We conclude that 3D-EOB-MRI may be an alternative method for depicting liver tumours adjacent to the hepatic veins and portal branches, and may provide additional information for surgical planning. Advances in radiological imaging techniques have been crucial in the development of hepatic surgery, and development of three-dimensional (3D) images has been helpful in surgical procedures. Better understanding of 3D appearances of liver structure may improve the outcome of curative surgery, and make more aggressive resection possible. Most 3D images of the liver have been reconstructed using volume data from multidetector row helical CT (MDCT) with multiphasic contrast-enhanced studies [1][2][3][4]. Although MDCT images are widely utilised, there may be some cases when a liver tumour can only be determined by MRI, or when a patient cannot undergo contrast-enhanced CT owing to risk of allergic reaction to the contrast medium.The hepatocyte-specific contrast agent gadolinium ethoxybenzyl diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) was developed to improve the detection and characterisation of focal liver lesions with MRI [5][6][7][8]. 3D images of tumours and vascular structures reconstructed from hepatobiliary phase Gd-EOB-DTPAenhanced MRI (3D-EOB-MRI) have not been previously reported.In this study, we reconstructed images obtained by 3D-EOB-MRI, and evaluated the efficacy in hepatic surgery.
Methods and materialsBetween June 2009 and September 2010, 26 consecutive patients (18 male, 8 female; age range 36-71 years; mean age 55 years) with liver tumours underwent Gd-EOB-DTPA-enhanced MRI at our institution within 3 weeks before surgery. The diagnoses of the liver tumours were confirmed pathologically after surgery. This study was approved by our institutional ethics review board, and each patient gave informed consent prior to the study.
MRI examinationAll MRI was performed with a 1.5-T superconducting MRI scanner (MagnetomH Symphony; Siemens, Erlangen, Germany) with a phased-array multicoil for signal reception. The liver was imaged in the axial planes in the following sequences. Baseline MR images included the respiratory-triggered transverse T 2 weighted turbo spin echo (TSE) sequence and transverse breath-hold T 1 weighted gradient-recalled echo sequence. Respiratorytriggered T 2 weighted imaging was obtained using the following parameters: repetition time (TR), 3300-5500 ms; echo time (TE), 85 ms; echo train length, 5; matrix, 192-2566256; and two signal averages. Breath-hold in-phase and out-of-phase T 1 weighted imaging was obtained using the following parameters: TR, 126 ms; TE, 2.3 (outof-phase) to 4.6 ms (in-phase); flip angle, 80 u ; matrix, 162-1926256; one signal average. For each sequence, 5-mm slices with no gap were used, and a field of view of 35-40 cm, depending on t...