Using mSIS, DNI, CRP, LDH and Albumin Levels for Predicting Burn-related Mortality

Akın, Merve; Akgün, Ali Emre

doi:10.4274/bmb.galenos.2021.07.085

Cited by 2 publications

(3 citation statements)

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“…Among the 24 included studies [ 43 – 66 ], 16 had retrospective designs [ 43 – 46 , 48 – 50 , 53 , 56 , 59 , 60 , 62 – 66 ]. Studies were conducted in Turkey( n = 5) [ 45 , 49 , 50 , 62 , 64 ], South Korea( n = 2) [ 58 , 60 ], Portugal( n = 1) [ 53 ], Iraq( n = 2) [ 52 , 57 ] Uruguay( n = 1) [ 43 ], India( n = 2) [ 44 , 63 ], Indonesia( n = 1) [ 47 ], China( n = 5) [ 46 , 56 , 59 , 65 , 66 ], USA ( n = 1) [ 55 ], France( n = 1) [ 54 ], Italy ( n = 1) [ 61 ], Germany ( n = 1) [ 51 ], and Sweden( n = 1) [ 48 ]. Ten studies reported in-hospital mortality [ 43 – 45 , 47 , 51 , 54 , 59 , 62 – 64 ], three reported 90- day mortality [ 46 , 56 , 60 ], one reported 51-day mortality [ 65 ] and one reported 28-day mortality [ 66 ].…”

Section: Resultsmentioning

confidence: 99%

“…Five studies assessed the CRP level of patients at time of admission to the hospital [ 47 , 50 , 63 , 65 , 66 ], one study assessed it between post-burn day 7 and 10 [ 55 ], one reported it on Day 3 [ 61 ], one in the first 48 h after admission [ 62 ], one in less than 6 h after admission [ 52 ], and two studies did not report this data [ 49 , 64 ] (Tables 1 and 2 ).…”

Section: Resultsmentioning

confidence: 99%

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Association of inflammatory biomarkers with overall survival in burn patients: a systematic review and meta-analysis

Nourigheimasi,

Yazdani,

Ghaedi

et al. 2024

BMC Emerg Med

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Introduction The inflammatory response to burn injuries can lead to organ dysfunction that ultimately results in increased mortality and morbidity. This meta-analysis was conducted to determine the efficacy of inflammatory biomarkers, including the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), procalcitonin (PCT), and C-reactive protein (CRP) as predictive tools of mortality among burn patients. Material and methods The biomarker levels of survivors and non-survivors were consolidated according to guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Three main databases were searched electronically: PubMed, Web of Science, and Scopus, on December 8, 2022. The Newcastle–Ottawa Quality Assessment Scale (NOS) was used to evaluate and score the methodological quality of the included studies. The standard mean difference (SMD) with a 95% confidence interval (CI) was utilized. Results Twenty-four studies were included in our systematic review and meta-analysis, (3636 total burn patients), of whom 2878 survived. We found that deceased burn patients had elevated levels of NLR (SMD = 0.60, 95% CI; 0.19–1.00, P < 0.001), CRP (SMD = 0.80, 95% CI; 0.02–1.58, P = 0.04), and PCT (SMD = 0.85, 95% CI; 0.45–1.24, P < 0.001), compared to survivors. However, we found no association between PLR and mortality among burn patients (SMD = 0.00, 95% CI; -0.14–0.15, P < 0.001). In addition, CRP was significantly higher in non-survivors (SMD = 0.80, 95% CI; 0.02–1.58, P =0.04). Similar results were also found about PCT (SMD = 0.85, 95% CI; 0.45–1.24, P < 0.001). When we analyzed the PCT data, collected in the first 24-48 hours, we found similar results; the PCT level was significantly higher in non-survivors in the immediate postinjury-period (SMD = 0.67, 95% CI; 0.31–1.02, P < 0.001). There was no publication bias among studies on the role of NLR in burn (Egger’s test P = 0.91). The based cut-off values for NLR (13), CRP (71), and PCT (1.77) yielded sensitivities of 69.2%, 100%, and 93.33%, and specificities of 76%, 72.22%, and 72.22% respectively. Discussion/Conclusions PCT is a marker of sepsis, therefore its elevated level is presumably associated with a higher incidence and severity of sepsis among non-survivors. In addition, NLR and CRP are promising biomarkers for predicting and guiding prevention against burn deaths in clinical settings.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association of inflammatory biomarkers with overall survival in burn patients: a systematic review and meta-analysis

Nourigheimasi,

Yazdani,

Ghaedi

et al. 2024

BMC Emerg Med

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“…In cases of major burns, inflammatory markers such as CRP, WBC, and ferritin usually elevate in almost every patient during the natural course of burn shock [ 9 ]. Clinical studies have demonstrated a relationship between these inflammatory markers and mortality [ 10 ]. However, these markers also serve as indicators of sepsis, which complicates the diagnosis of sepsis in burn patients [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Bacteremia in a Burn Patient: A Case Report of Achromobacter Xylosoxidans and Denitrificans

Özer,

Akin,

Yasti

2023

Cureus

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Achromobacter is a rare bacteria that causes bacteremia in immune-compromised patients. In this case, a 26-year-old male patient with major burns with a positive blood culture for Achromobacter is presented. A rare bacterium, Achromobacter xylosoxidans , and denitrificans , was detected in the blood culture of a patient who was hospitalized due to major burn trauma and had delayed wound healing and had no graft take. After treatment with culture-specific antibiotics, the patients' acute phase reactants decreased, and he was discharged with 100% graft-take. Sepsis is the most common cause of death in major burns. Endogenous and exogenous bacteria cause sepsis. Bacteremia and sepsis are the most important factors affecting wound healing in burn patients. This case shows that rare opportunistic bacteria such as Achromobacter spp. should be considered in major burn patients with delayed wound healing and recurrent graft lysis.

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Using mSIS, DNI, CRP, LDH and Albumin Levels for Predicting Burn-related Mortality

Cited by 2 publications

References 0 publications

Association of inflammatory biomarkers with overall survival in burn patients: a systematic review and meta-analysis

Association of inflammatory biomarkers with overall survival in burn patients: a systematic review and meta-analysis

A Rare Bacteremia in a Burn Patient: A Case Report of Achromobacter Xylosoxidans and Denitrificans

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