Using MRI to measure position and anatomy changes and assess their impact on the accuracy of hyperthermia treatment planning for cervical cancer

VilasBoas‐Ribeiro, Iva; Franckena, Martine; Rhoon, Gerard C. van; Hernández-Tamames, Juan Antonio; Paulides, Margarethus M.

doi:10.1080/02656736.2022.2151648

Cited by 3 publications

(5 citation statements)

References 70 publications

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“…However, it is important to highlight that the realistic model consistently demonstrates lower SAR values when compared to the simple model. This result is consistent with other works, con rming that SAR is in uenced by several anatomical factors [23][24][25].…”

Section: Discussionsupporting

confidence: 93%

Utilizing a Floating Sleeve Antenna for Interstitial Microwave Hyperthermia Treatment of Superficial and Deep-seated Breast Tumors

Eltigani,

Ahmed

2023

Preprint

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Purpose: Breast cancer is a leading cause of mortality among women worldwide. While chemotherapy and radiotherapy are commonly used treatment modalities, they have several side effects that can negatively impact the patient. In this study, we explore the application of a floating sleeve antenna for interstitial microwave hyperthermia for breast tumors. Method: Two distinct 3D breast models were employed: a simplified semi-spherical and a highly detailed anatomical model. Both models featured superficial and deep-seated tumors. The floating sleeve antenna was inserted into the breast models, and simulations were con-ducted to assess the specific absorption rate (SAR) and temperature distribution. Results: In the simple model, the superficial tumor reached a maximum temperature of 50.7 ºC, while the deep-seated tumor maintained a uniform temperature of 48.9 ºC. In contrast, the realistic model achieved a maximum temperature of 46.2 ºC for the superficial tumor and 41.47 ºC for the deep-seated tumor within the same 15-minute treatment period. These results demonstrate the ability of the antenna to attain the desired hyperthermia temperatures (above 39 °C to 45 °C). Conclusion: microwave hyperthermia using a floating sleeve antenna has the potential to be an effective and safe alternative treatment for breast cancer with minimal side effects

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Section: Discussionsupporting

confidence: 93%

Utilizing a Floating Sleeve Antenna for Interstitial Microwave Hyperthermia Treatment of Superficial and Deep-seated Breast Tumors

Eltigani,

Ahmed

2023

Preprint

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“…De Greef et al [33] used temperature-based optimization and found that the changes in tumor temperatures were between 0.3°C-0.5°C when the accuracy of patient positioning was within 1-2cm in the zdirection (superior-inferior direction). As shown in our previous study [21], we mainly found position changes in the ydirection (posterior-anterior direction), while these were less than 1cm in the z-direction. We justify the difference by the fact that we included anatomy changes and shifts in the y-direction.…”

Section: Discussionsupporting

confidence: 78%

“…Compared to other studies, we found similar or higher errors when using temperature-based optimization. Gellermann et al [8] reported that displacements up to 3cm (as in our study [21]) caused temperature deviations up to ±0.5°C in ΔT90 using temperature-based optimization. De Greef et al [33] used temperature-based optimization and found that the changes in tumor temperatures were between 0.3°C-0.5°C when the accuracy of patient positioning was within 1-2cm in the zdirection (superior-inferior direction).…”

Section: Discussionsupporting

confidence: 59%

“…Regarding the MR imaging protocol, we used the 3D spoiled gradient recalled echo (SPGR) pulse sequence to visualize gastrointestinal air and the PROPELLER sequence to obtain high-resolution anatomic images. The details about the experiment and the MR protocol can be found in our previous work [21] .

Fig.…”

Section: Methodsmentioning

confidence: 99%

“…The electromagnetic (EM) field for each antenna was calculated using the Finite-Difference-Time-Domain (FDTD) solver in Sim4life (v6.2 Zurich MedTech AG, Zurich, Switzerland). The details about the EM simulations are given in our previous work [21] . Furthermore, we computed the 3D steady-state temperature distributions using the Pennes' Bio-Heat Equation, which formulation is given in (1) [22] , in Sim4life.…”

Section: Methodsmentioning

confidence: 99%

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Adapting Temperature Predictions to MR Imaging in Treatment Position to Improve Simulation-Guided Hyperthermia for Cervical Cancer

VilasBoas-Ribeiro,

Sumser,

Nouwens

et al. 2024

IEEE Open J. Eng. Med. Biol.

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Hyperthermia treatment consists of elevating the temperature of the tumor to increase the effectiveness of radiotherapy and chemotherapy. Hyperthermia treatment planning (HTP) is an important tool to optimize treatment quality using pre-treatment temperature predictions. The accuracy of these predictions depends on modeling uncertainties such as tissue properties and positioning. In this study, we evaluated if HTP accuracy improves when the patient is imaged inside the applicator at the start of treatment. Because perfusion is a major uncertainty source, the importance of accurate treatment position and anatomy was evaluated using different perfusion values. Volunteers were scanned using MR imaging without (“planning setup”) and with the MR-compatible hyperthermia device (“treatment setup”). Temperature-based quality indicators were used to assess the differences between the standard, apparent and the optimized hyperthermia dose. We conclude that pre-treatment imaging can improve HTP predictions accuracy but also, that tissue perfusion modelling is crucial if temperature-based optimization is applied.

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In-situ registration subtraction image segmentation algorithm for spatiotemporal visualization of copper adsorption onto corn stalk-derived pellet biochar by micro-computed tomography

Song,

Xiong,

Zhao

et al. 2024

Bioresource Technology

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Using MRI to measure position and anatomy changes and assess their impact on the accuracy of hyperthermia treatment planning for cervical cancer

Cited by 3 publications

References 70 publications

Utilizing a Floating Sleeve Antenna for Interstitial Microwave Hyperthermia Treatment of Superficial and Deep-seated Breast Tumors

Utilizing a Floating Sleeve Antenna for Interstitial Microwave Hyperthermia Treatment of Superficial and Deep-seated Breast Tumors

Adapting Temperature Predictions to MR Imaging in Treatment Position to Improve Simulation-Guided Hyperthermia for Cervical Cancer

In-situ registration subtraction image segmentation algorithm for spatiotemporal visualization of copper adsorption onto corn stalk-derived pellet biochar by micro-computed tomography

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