Using Models to (Re-)Design Synthetic Circuits

McCallum, Giselle; Potvin-Trottier, Laurent

doi:10.1007/978-1-0716-1032-9_3

Cited by 2 publications

(1 citation statement)

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“…The behaviour of cells on plates is often used to illustrate SynBio construction [see a famous early illustration in (Elowitz and Leibler, 2000)]. However, a large number of phenomenological models can be used to account for this behaviour (McCallum and Potvin‐Trottier, 2021). For example, it has long been observed that colonies on plates often generate patterns that have dendritic shapes (Fall et al ., 2004).…”

Section: Synthetic Biology In Silicomentioning

confidence: 99%

In vivo, in vitro and in silico: an open space for the development of microbe‐based applications of synthetic biology

Danchin

2021

Microbial Biotechnology

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Living systems are studied using three complementary approaches: living cells, cell-free systems and computer-mediated modelling. Progresses in understanding, allowing researchers to create novel chassis and industrial processes rest on a cycle that combines in vivo, in vitro and in silico studies. This design-build-test-learn iteration loop cycle between experiments and analyses combines together physiology, genetics, biochemistry and bioinformatics in a way that keeps going forward. Because computeraided approaches are not directly constrained by the material nature of the entities of interest, we illustrate here how this virtuous cycle allows researchers to explore chemistry which is foreign to that present in extant life, from whole chassis to novel metabolic cycles. Particular emphasis is placed on the importance of evolution.

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Section: Synthetic Biology In Silicomentioning

confidence: 99%