Using models in different stages of process life-cycle

Sundquist, S.; Ilme, J.; Määttä, Jorma A.; Турунен, Илкка

doi:10.1016/s0098-1354(00)00326-4

Cited by 5 publications

(2 citation statements)

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“…Figure 1-4 shows typical business activities in product and process development. This scheme is based on previous studies involving chemical (Sugiyama, 2007), agro-industrial (Sundquist et al, 2000), and pharmaceutical (Basu et al, 1999;Lepore and Spavins, 2008;Nasr, 2007) models. Five activities are included in this scheme: Define product performance, Design product, Design recipe, Design facility, and Produce.…”

Section: Lifecycle Engineering In Pharmaceutical Developmentmentioning

confidence: 99%

Systems Approach to Process Lifecycle Engineering in Pharmaceutical Production

Kawai

Seki

Kitajima

et al. 2014

KAGAKU KOGAKU RONBUNSHU

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implementation, and change management of LCE. Applicability of this framework is shown using actual cases analysis of a pharmaceutical company. Chapter 4 presents a system to support information transactions between recipe scientists and process engineers; such transactions tend to fail without a suitable management system. In addition, a case-based reasoning approach is introduced as a cooperative method in the system to find relations between errors and deviations. Chapter 5 concludes this dissertation with future prospects. Structure of the Ph D thesis.

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Section: Lifecycle Engineering In Pharmaceutical Developmentmentioning

confidence: 99%

Systems Approach to Process Lifecycle Engineering in Pharmaceutical Production

Kawai

Seki

Kitajima

et al. 2014

KAGAKU KOGAKU RONBUNSHU

View full text Add to dashboard Cite

show abstract

“…These methodologies of integrated design have a focus on a specific stage of the whole design procedure. In general, process design typically uses a hierarchical approach27 and consists of different phases including process chemistry, conceptual design, piloting, detailed design, construction start‐up, and redesign 28. So far, three authors reflected such nature of process design, and proposed design frameworks that include different steps of multiobjective evaluation.…”

Section: Introductionmentioning

confidence: 99%

Decision framework for chemical process design including different stages of environmental, health, and safety assessment

et al. 2008

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in Wiley InterScience (www.interscience.wiley.com).In recent years, many chemical companies have adopted the concept of sustainable development as a core business value. In this context and with focus on early phases, we present a novel design framework that comprises four stages of process modeling and multiobjective evaluation considering monetary and nonmonetary aspects. Each stage is characterized by the available information as a basis for process modeling and assessment. Appropriate modeling approaches, and evaluation indicators for economy, life-cycle environmental impacts, environment, health, and safety (EHS) hazard, and technical aspects are selected for each defined stage. The proposed framework is demonstrated on the design of a methyl methacrylate (MMA) process: considering 17 synthesis routes, the framework is mimicked step-by-step, to select the route with the best multiobjective performances, and to produce an optimized process flowsheet. As a validation of the framework, evaluation profile of six routes over all stages are compared, and crucial points are identified that should be estimated considerably well in early stages of the framework.

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